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Q30KR1

- DB109_HUMAN

UniProt

Q30KR1 - DB109_HUMAN

Protein

Beta-defensin 109

Gene

DEFB109P1

more
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 109
    Alternative name(s):
    Defensin, beta 109
    Defensin, beta 109, pseudogene 1/1B
    Gene namesi
    Name:DEFB109P1
    Synonyms:DEFB109, DEFB109A
    AND
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:18090. DEFB109P1.
    HGNC:33469. DEFB109P1B.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 8765Beta-defensin 109PRO_0000045333Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 59By similarity
    Disulfide bondi38 ↔ 53By similarity
    Disulfide bondi43 ↔ 60By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ30KR1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ30KR1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KR1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG081406.
    InParanoidiQ30KR1.
    PhylomeDBiQ30KR1.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    IPR006080. Defensin_beta/neutrophil.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]
    SMARTiSM00048. DEFSN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KR1-1 [UniParc]FASTAAdd to Basket

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    MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI   50
    GACRRRMKCC RAWWILMPIP TPLIMSDYQE PLKPNLK 87
    Length:87
    Mass (Da):9,886
    Last modified:December 6, 2005 - v1
    Checksum:iF9C501C495B608ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012013 mRNA. Translation: AAY59749.1.
    UniGeneiHs.616079.

    Genome annotation databases

    UCSCiuc003wre.5. human.

    Polymorphism databases

    DMDMi84028868.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012013 mRNA. Translation: AAY59749.1 .
    UniGenei Hs.616079.

    3D structure databases

    ProteinModelPortali Q30KR1.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 84028868.

    Proteomic databases

    PRIDEi Q30KR1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc003wre.5. human.

    Organism-specific databases

    GeneCardsi GC08M012253.
    GC08P007158.
    H-InvDB HIX0168826.
    HIX0168827.
    HGNCi HGNC:18090. DEFB109P1.
    HGNC:33469. DEFB109P1B.
    neXtProti NX_Q30KR1.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG081406.
    InParanoidi Q30KR1.
    PhylomeDBi Q30KR1.

    Miscellaneous databases

    NextBioi 13613995.
    PROi Q30KR1.

    Gene expression databases

    Genevestigatori Q30KR1.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    IPR006080. Defensin_beta/neutrophil.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    SMARTi SM00048. DEFSN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDB109_HUMAN
    AccessioniPrimary (citable) accession number: Q30KR1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3