Q30KR1 (DB109_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 109

Alternative name(s):
Defensin, beta 109
Defensin, beta 109, pseudogene 1/1B

Gene names

Name:	DEFB109P1
Synonyms:	DEFB109, DEFB109A
AND
Name:	DEFB109P1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	87 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has antibacterial activity By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 87	65	Beta-defensin 109		PRO_0000045333
Amino acid modifications
	Disulfide bond	31 ↔ 59		By similarity
	Disulfide bond	38 ↔ 53		By similarity
	Disulfide bond	43 ↔ 60		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30KR1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: F9C501C495B608ED	FASTA	87	9,886
	10 20 30 40 50 60 MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI GACRRRMKCC 70 80 RAWWILMPIP TPLIMSDYQE PLKPNLK

References

[1]

"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012013 mRNA. Translation: AAY59749.1.
IPI	IPI00655843.
UniGene	Hs.616079.
3D structure databases
ProteinModelPortal	Q30KR1.
ModBase	Search...
Polymorphism databases
DMDM	84028868.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC08M012253. GC08P007158.
H-InvDB	HIX0168826. HIX0168827.
HGNC	HGNC:18090. DEFB109P1. HGNC:33469. DEFB109P1B.
neXtProt	NX_Q30KR1.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG081406.
InParanoid	Q30KR1.
Gene expression databases
Genevestigator	Q30KR1.
Family and domain databases
InterPro	IPR025933. Beta_defensin. IPR006080. Defensin_beta/neutrophil. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
SMART	SM00048. DEFSN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13613995.

Entry information

Entry name

DB109_HUMAN

Accession

Primary (citable) accession number: Q30KR1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.