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Protein

Beta-defensin 109

Gene

DEFB109P1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 109
Alternative name(s):
Defensin, beta 109
Defensin, beta 109, pseudogene 1/1B
Gene namesi
Name:DEFB109P1
Synonyms:DEFB109, DEFB109A
AND
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:18090. DEFB109P1.
HGNC:33469. DEFB109P1B.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 8765Beta-defensin 109PRO_0000045333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59By similarity
Disulfide bondi38 ↔ 53By similarity
Disulfide bondi43 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KR1.

Expressioni

Gene expression databases

GenevestigatoriQ30KR1.

Structurei

3D structure databases

ProteinModelPortaliQ30KR1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG081406.
InParanoidiQ30KR1.
PhylomeDBiQ30KR1.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI
60 70 80
GACRRRMKCC RAWWILMPIP TPLIMSDYQE PLKPNLK
Length:87
Mass (Da):9,886
Last modified:December 5, 2005 - v1
Checksum:iF9C501C495B608ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012013 mRNA. Translation: AAY59749.1.
UniGeneiHs.616079.
Hs.721640.

Genome annotation databases

UCSCiuc003wre.5. human.

Polymorphism databases

DMDMi84028868.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012013 mRNA. Translation: AAY59749.1.
UniGeneiHs.616079.
Hs.721640.

3D structure databases

ProteinModelPortaliQ30KR1.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi84028868.

Proteomic databases

PRIDEiQ30KR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc003wre.5. human.

Organism-specific databases

GeneCardsiGC08M012253.
GC08P007158.
H-InvDBHIX0168826.
HIX0168827.
HGNCiHGNC:18090. DEFB109P1.
HGNC:33469. DEFB109P1B.
neXtProtiNX_Q30KR1.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG081406.
InParanoidiQ30KR1.
PhylomeDBiQ30KR1.

Miscellaneous databases

NextBioi13613995.
PROiQ30KR1.

Gene expression databases

GenevestigatoriQ30KR1.

Family and domain databases

InterProiIPR025933. Beta_defensin.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
SMARTiSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDB109_HUMAN
AccessioniPrimary (citable) accession number: Q30KR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2005
Last sequence update: December 5, 2005
Last modified: January 6, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.