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Q30KR1 (DB109_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 109
Alternative name(s):
Defensin, beta 109
Defensin, beta 109, pseudogene 1/1B
Gene names
Name:DEFB109P1
Synonyms:DEFB109, DEFB109A
AND
Name:DEFB109P1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length87 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 8765Beta-defensin 109
PRO_0000045333

Amino acid modifications

Disulfide bond31 ↔ 59 By similarity
Disulfide bond38 ↔ 53 By similarity
Disulfide bond43 ↔ 60 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30KR1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: F9C501C495B608ED

FASTA879,886
        10         20         30         40         50         60 
MRLHLLLLIL LLFSILLSPV RGGLGPAEGH CLNLFGVCRT DVCNIVEDQI GACRRRMKCC 

        70         80 
RAWWILMPIP TPLIMSDYQE PLKPNLK 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012013 mRNA. Translation: AAY59749.1.
UniGeneHs.616079.

3D structure databases

ProteinModelPortalQ30KR1.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM84028868.

Proteomic databases

PRIDEQ30KR1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc003wre.5. human.

Organism-specific databases

GeneCardsGC08M012253.
GC08P007158.
H-InvDBHIX0168826.
HIX0168827.
HGNCHGNC:18090. DEFB109P1.
HGNC:33469. DEFB109P1B.
neXtProtNX_Q30KR1.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG081406.
InParanoidQ30KR1.
PhylomeDBQ30KR1.

Gene expression databases

GenevestigatorQ30KR1.

Family and domain databases

InterProIPR025933. Beta_defensin.
IPR006080. Defensin_beta/neutrophil.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
SMARTSM00048. DEFSN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13613995.
PROQ30KR1.

Entry information

Entry nameDB109_HUMAN
AccessionPrimary (citable) accession number: Q30KR1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM