ID   DB110_HUMAN             Reviewed;          67 AA.
AC   Q30KQ9; Q30KR0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   24-JAN-2024, entry version 119.
DE   RecName: Full=Beta-defensin 110;
DE   AltName: Full=Beta-defensin 10;
DE            Short=DEFB-10;
DE   AltName: Full=Beta-defensin 11;
DE            Short=DEFB-11;
DE   AltName: Full=Beta-defensin 111;
DE   AltName: Full=Defensin, beta 110;
DE   AltName: Full=Defensin, beta 111;
DE   Flags: Precursor;
GN   Name=DEFB110; Synonyms=DEFB10, DEFB11, DEFB111;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q30KQ9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q30KQ9-2; Sequence=VSP_038146;
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012014; AAY59750.1; -; mRNA.
DR   EMBL; DQ012015; AAY59751.1; -; mRNA.
DR   EMBL; AL138879; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS34475.1; -. [Q30KQ9-1]
DR   CCDS; CCDS43473.1; -. [Q30KQ9-2]
DR   RefSeq; NP_001032586.1; NM_001037497.1. [Q30KQ9-1]
DR   RefSeq; NP_001032817.1; NM_001037728.2. [Q30KQ9-2]
DR   AlphaFoldDB; Q30KQ9; -.
DR   SMR; Q30KQ9; -.
DR   BioGRID; 128838; 16.
DR   STRING; 9606.ENSP00000360190; -.
DR   iPTMnet; Q30KQ9; -.
DR   BioMuta; DEFB110; -.
DR   DMDM; 84028871; -.
DR   MassIVE; Q30KQ9; -.
DR   PaxDb; 9606-ENSP00000360190; -.
DR   Antibodypedia; 57764; 24 antibodies from 5 providers.
DR   DNASU; 245913; -.
DR   Ensembl; ENST00000371148.3; ENSP00000360190.2; ENSG00000203970.4. [Q30KQ9-1]
DR   Ensembl; ENST00000393660.2; ENSP00000377270.2; ENSG00000203970.4. [Q30KQ9-2]
DR   GeneID; 245913; -.
DR   KEGG; hsa:245913; -.
DR   MANE-Select; ENST00000371148.3; ENSP00000360190.2; NM_001037497.2; NP_001032586.1.
DR   UCSC; uc003pac.3; human. [Q30KQ9-1]
DR   AGR; HGNC:18091; -.
DR   CTD; 245913; -.
DR   GeneCards; DEFB110; -.
DR   HGNC; HGNC:18091; DEFB110.
DR   HPA; ENSG00000203970; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KQ9; -.
DR   OpenTargets; ENSG00000203970; -.
DR   PharmGKB; PA38487; -.
DR   VEuPathDB; HostDB:ENSG00000203970; -.
DR   eggNOG; ENOG502TGN0; Eukaryota.
DR   GeneTree; ENSGT00390000006761; -.
DR   HOGENOM; CLU_187020_0_0_1; -.
DR   InParanoid; Q30KQ9; -.
DR   OMA; IRIAYCM; -.
DR   OrthoDB; 5253895at2759; -.
DR   PhylomeDB; Q30KQ9; -.
DR   PathwayCommons; Q30KQ9; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   BioGRID-ORCS; 245913; 6 hits in 1046 CRISPR screens.
DR   GenomeRNAi; 245913; -.
DR   Pharos; Q30KQ9; Tdark.
DR   PRO; PR:Q30KQ9; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q30KQ9; Protein.
DR   Bgee; ENSG00000203970; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 36 other cell types or tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031731; F:CCR6 chemokine receptor binding; IBA:GO_Central.
DR   GO; GO:0042056; F:chemoattractant activity; IBA:GO_Central.
DR   GO; GO:0060326; P:cell chemotaxis; IBA:GO_Central.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR20515; BETA-DEFENSIN; 1.
DR   PANTHER; PTHR20515:SF19; BETA-DEFENSIN 110; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Antibiotic; Antimicrobial; Defensin; Disulfide bond;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..67
FT                   /note="Beta-defensin 110"
FT                   /id="PRO_0000045336"
FT   DISULFID        35..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..64
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         20..67
FT                   /note="KKKYPEYGSLDLRRECRIGNGQCKNQCHENEIRIAYCIRPGTHCCLQQ ->
FT                   RSNFEPKYRFERCEKVRGICKTFCDDVEYDYGYCIKWRSQCCV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16033865"
FT                   /id="VSP_038146"
SQ   SEQUENCE   67 AA;  8001 MW;  923DBCA99BC9B3E9 CRC64;
     MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE IRIAYCIRPG
     THCCLQQ
//