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Protein

Beta-defensin 110

Gene

DEFB110

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 110
Alternative name(s):
Beta-defensin 10
Short name:
DEFB-10
Beta-defensin 11
Short name:
DEFB-11
Beta-defensin 111
Defensin, beta 110
Defensin, beta 111
Gene namesi
Name:DEFB110
Synonyms:DEFB10, DEFB11, DEFB111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18091. DEFB110.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38487.
PA38488.

Polymorphism and mutation databases

BioMutaiDEFB110.
DMDMi84028871.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 6748Beta-defensin 110PRO_0000045336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 63By similarity
Disulfide bondi42 ↔ 56By similarity
Disulfide bondi46 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KQ9.

Expressioni

Gene expression databases

BgeeiQ30KQ9.
CleanExiHS_DEFB111.

Organism-specific databases

HPAiHPA060517.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360190.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG133758.
GeneTreeiENSGT00390000006761.
HOGENOMiHOG000112150.
HOVERGENiHBG063273.
InParanoidiQ30KQ9.
OMAiTHCCLQK.
OrthoDBiEOG74N5KS.
PhylomeDBiQ30KQ9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q30KQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE
60
IRIAYCIRPG THCCLQQ
Length:67
Mass (Da):8,001
Last modified:December 6, 2005 - v1
Checksum:i923DBCA99BC9B3E9
GO
Isoform 2 (identifier: Q30KQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-67: KKKYPEYGSL...RPGTHCCLQQ → RSNFEPKYRF...CIKWRSQCCV

Show »
Length:62
Mass (Da):7,672
Checksum:iE03991B1C6F1156F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 6748KKKYP…CCLQQ → RSNFEPKYRFERCEKVRGIC KTFCDDVEYDYGYCIKWRSQ CCV in isoform 2. 1 PublicationVSP_038146Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012014 mRNA. Translation: AAY59750.1.
DQ012015 mRNA. Translation: AAY59751.1.
AL138879 Genomic DNA. No translation available.
CCDSiCCDS34475.1. [Q30KQ9-1]
CCDS43473.1. [Q30KQ9-2]
RefSeqiNP_001032586.1. NM_001037497.1. [Q30KQ9-1]
NP_001032817.1. NM_001037728.2. [Q30KQ9-2]
UniGeneiHs.571093.

Genome annotation databases

EnsembliENST00000371148; ENSP00000360190; ENSG00000203970.
ENST00000393660; ENSP00000377270; ENSG00000203970. [Q30KQ9-2]
GeneIDi245913.
KEGGihsa:245913.
UCSCiuc003pac.3. human. [Q30KQ9-1]
uc011dwr.2. human. [Q30KQ9-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012014 mRNA. Translation: AAY59750.1.
DQ012015 mRNA. Translation: AAY59751.1.
AL138879 Genomic DNA. No translation available.
CCDSiCCDS34475.1. [Q30KQ9-1]
CCDS43473.1. [Q30KQ9-2]
RefSeqiNP_001032586.1. NM_001037497.1. [Q30KQ9-1]
NP_001032817.1. NM_001037728.2. [Q30KQ9-2]
UniGeneiHs.571093.

3D structure databases

ProteinModelPortaliQ30KQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000360190.

Polymorphism and mutation databases

BioMutaiDEFB110.
DMDMi84028871.

Proteomic databases

PRIDEiQ30KQ9.

Protocols and materials databases

DNASUi245913.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371148; ENSP00000360190; ENSG00000203970.
ENST00000393660; ENSP00000377270; ENSG00000203970. [Q30KQ9-2]
GeneIDi245913.
KEGGihsa:245913.
UCSCiuc003pac.3. human. [Q30KQ9-1]
uc011dwr.2. human. [Q30KQ9-2]

Organism-specific databases

CTDi245913.
GeneCardsiGC06M049976.
HGNCiHGNC:18091. DEFB110.
HPAiHPA060517.
neXtProtiNX_Q30KQ9.
PharmGKBiPA38487.
PA38488.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG133758.
GeneTreeiENSGT00390000006761.
HOGENOMiHOG000112150.
HOVERGENiHBG063273.
InParanoidiQ30KQ9.
OMAiTHCCLQK.
OrthoDBiEOG74N5KS.
PhylomeDBiQ30KQ9.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii245913.
NextBioi91763.
PROiQ30KQ9.

Gene expression databases

BgeeiQ30KQ9.
CleanExiHS_DEFB111.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDB110_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ9
Secondary accession number(s): Q30KR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: July 22, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.