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Q30KQ9

- DB110_HUMAN

UniProt

Q30KQ9 - DB110_HUMAN

Protein

Beta-defensin 110

Gene

DEFB110

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 110
    Alternative name(s):
    Beta-defensin 10
    Short name:
    DEFB-10
    Beta-defensin 11
    Short name:
    DEFB-11
    Beta-defensin 111
    Defensin, beta 110
    Defensin, beta 111
    Gene namesi
    Name:DEFB110
    Synonyms:DEFB10, DEFB11, DEFB111
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18091. DEFB110.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38487.
    PA38488.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 6748Beta-defensin 110PRO_0000045336Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 63By similarity
    Disulfide bondi42 ↔ 56By similarity
    Disulfide bondi46 ↔ 64By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ30KQ9.

    Expressioni

    Gene expression databases

    BgeeiQ30KQ9.
    CleanExiHS_DEFB111.
    GenevestigatoriQ30KQ9.

    Organism-specific databases

    HPAiHPA060517.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000360190.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG133758.
    HOGENOMiHOG000112150.
    HOVERGENiHBG063273.
    InParanoidiQ30KQ9.
    OMAiEIRIAYC.
    OrthoDBiEOG74N5KS.
    PhylomeDBiQ30KQ9.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q30KQ9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE   50
    IRIAYCIRPG THCCLQQ 67
    Length:67
    Mass (Da):8,001
    Last modified:December 6, 2005 - v1
    Checksum:i923DBCA99BC9B3E9
    GO
    Isoform 2 (identifier: Q30KQ9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         20-67: KKKYPEYGSL...RPGTHCCLQQ → RSNFEPKYRF...CIKWRSQCCV

    Show »
    Length:62
    Mass (Da):7,672
    Checksum:iE03991B1C6F1156F
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei20 – 6748KKKYP…CCLQQ → RSNFEPKYRFERCEKVRGIC KTFCDDVEYDYGYCIKWRSQ CCV in isoform 2. 1 PublicationVSP_038146Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012014 mRNA. Translation: AAY59750.1.
    DQ012015 mRNA. Translation: AAY59751.1.
    AL138879 Genomic DNA. No translation available.
    CCDSiCCDS34475.1. [Q30KQ9-1]
    CCDS43473.1. [Q30KQ9-2]
    RefSeqiNP_001032586.1. NM_001037497.1. [Q30KQ9-1]
    NP_001032817.1. NM_001037728.2. [Q30KQ9-2]
    UniGeneiHs.571093.

    Genome annotation databases

    EnsembliENST00000371148; ENSP00000360190; ENSG00000203970. [Q30KQ9-1]
    ENST00000393660; ENSP00000377270; ENSG00000203970. [Q30KQ9-2]
    GeneIDi245913.
    KEGGihsa:245913.
    UCSCiuc003pac.3. human. [Q30KQ9-1]
    uc011dwr.2. human. [Q30KQ9-2]

    Polymorphism databases

    DMDMi84028871.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012014 mRNA. Translation: AAY59750.1 .
    DQ012015 mRNA. Translation: AAY59751.1 .
    AL138879 Genomic DNA. No translation available.
    CCDSi CCDS34475.1. [Q30KQ9-1 ]
    CCDS43473.1. [Q30KQ9-2 ]
    RefSeqi NP_001032586.1. NM_001037497.1. [Q30KQ9-1 ]
    NP_001032817.1. NM_001037728.2. [Q30KQ9-2 ]
    UniGenei Hs.571093.

    3D structure databases

    ProteinModelPortali Q30KQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000360190.

    Polymorphism databases

    DMDMi 84028871.

    Proteomic databases

    PRIDEi Q30KQ9.

    Protocols and materials databases

    DNASUi 245913.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371148 ; ENSP00000360190 ; ENSG00000203970 . [Q30KQ9-1 ]
    ENST00000393660 ; ENSP00000377270 ; ENSG00000203970 . [Q30KQ9-2 ]
    GeneIDi 245913.
    KEGGi hsa:245913.
    UCSCi uc003pac.3. human. [Q30KQ9-1 ]
    uc011dwr.2. human. [Q30KQ9-2 ]

    Organism-specific databases

    CTDi 245913.
    GeneCardsi GC06M049976.
    HGNCi HGNC:18091. DEFB110.
    HPAi HPA060517.
    neXtProti NX_Q30KQ9.
    PharmGKBi PA38487.
    PA38488.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG133758.
    HOGENOMi HOG000112150.
    HOVERGENi HBG063273.
    InParanoidi Q30KQ9.
    OMAi EIRIAYC.
    OrthoDBi EOG74N5KS.
    PhylomeDBi Q30KQ9.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 91763.
    PROi Q30KQ9.

    Gene expression databases

    Bgeei Q30KQ9.
    CleanExi HS_DEFB111.
    Genevestigatori Q30KQ9.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDB110_HUMAN
    AccessioniPrimary (citable) accession number: Q30KQ9
    Secondary accession number(s): Q30KR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3