Q30KQ9 (DB110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 110

Alternative name(s):
Beta-defensin 10
Short name=DEFB-10
Beta-defensin 11
Short name=DEFB-11
Beta-defensin 111
Defensin, beta 110
Defensin, beta 111

Gene names

Name:	DEFB110
Synonyms:	DEFB10, DEFB11, DEFB111

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q30KQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q30KQ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-67: KKKYPEYGSL...RPGTHCCLQQ → RSNFEPKYRF...CIKWRSQCCV

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 67	48	Beta-defensin 110		PRO_0000045336
Amino acid modifications
	Disulfide bond	35 ↔ 63		By similarity
	Disulfide bond	42 ↔ 56		By similarity
	Disulfide bond	46 ↔ 64		By similarity
Natural variations
	Alternative sequence	20 – 67	48	KKKYP…CCLQQ → RSNFEPKYRFERCEKVRGIC KTFCDDVEYDYGYCIKWRSQ CCV in isoform 2.		VSP_038146

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 923DBCA99BC9B3E9	FASTA	67	8,001
	10 20 30 40 50 60 MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE IRIAYCIRPG THCCLQQ
	Isoform 2 [UniParc]. Checksum: E03991B1C6F1156F	FASTA	62	7,672
	10 20 30 40 50 60 MKIQLFFFIL HFWVTILPAR SNFEPKYRFE RCEKVRGICK TFCDDVEYDY GYCIKWRSQC CV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012014 mRNA. Translation: AAY59750.1. DQ012015 mRNA. Translation: AAY59751.1. AL138879 Genomic DNA. No translation available.
IPI	IPI00656027. IPI00656142.
RefSeq	NP_001032586.1. NM_001037497.1. NP_001032817.1. NM_001037728.2.
UniGene	Hs.571093.
3D structure databases
ProteinModelPortal	Q30KQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360190.
Polymorphism databases
DMDM	84028871.
Proteomic databases
PRIDE	Q30KQ9.
Protocols and materials databases
DNASU	245913.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371148; ENSP00000360190; ENSG00000203970. ENST00000393660; ENSP00000377270; ENSG00000203970.
GeneID	245913.
KEGG	hsa:245913.
UCSC	uc003pac.3. human. uc011dwr.2. human.
Organism-specific databases
CTD	245913.
GeneCards	GC06M049976.
HGNC	HGNC:18091. DEFB110.
neXtProt	NX_Q30KQ9.
PharmGKB	PA38487. PA38488.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG133758.
HOGENOM	HOG000112150.
HOVERGEN	HBG063273.
InParanoid	Q30KQ9.
OMA	EIRIAYC.
OrthoDB	EOG4J6RSJ.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q30KQ9.
CleanEx	HS_DEFB111.
Genevestigator	Q30KQ9.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91763.

Entry information

Entry name

DB110_HUMAN

Accession

Primary (citable) accession number: Q30KQ9
Secondary accession number(s): Q30KR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.