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Q30KQ9

- DB110_HUMAN

UniProt

Q30KQ9 - DB110_HUMAN

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Protein

Beta-defensin 110

Gene

DEFB110

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 110
Alternative name(s):
Beta-defensin 10
Short name:
DEFB-10
Beta-defensin 11
Short name:
DEFB-11
Beta-defensin 111
Defensin, beta 110
Defensin, beta 111
Gene namesi
Name:DEFB110
Synonyms:DEFB10, DEFB11, DEFB111
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18091. DEFB110.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38487.
PA38488.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 6748Beta-defensin 110PRO_0000045336Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 63By similarity
Disulfide bondi42 ↔ 56By similarity
Disulfide bondi46 ↔ 64By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KQ9.

Expressioni

Gene expression databases

BgeeiQ30KQ9.
CleanExiHS_DEFB111.
GenevestigatoriQ30KQ9.

Organism-specific databases

HPAiHPA060517.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000360190.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG133758.
GeneTreeiENSGT00390000006761.
HOGENOMiHOG000112150.
HOVERGENiHBG063273.
InParanoidiQ30KQ9.
OMAiEIRIAYC.
OrthoDBiEOG74N5KS.
PhylomeDBiQ30KQ9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q30KQ9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE
60
IRIAYCIRPG THCCLQQ
Length:67
Mass (Da):8,001
Last modified:December 6, 2005 - v1
Checksum:i923DBCA99BC9B3E9
GO
Isoform 2 (identifier: Q30KQ9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-67: KKKYPEYGSL...RPGTHCCLQQ → RSNFEPKYRF...CIKWRSQCCV

Show »
Length:62
Mass (Da):7,672
Checksum:iE03991B1C6F1156F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei20 – 6748KKKYP…CCLQQ → RSNFEPKYRFERCEKVRGIC KTFCDDVEYDYGYCIKWRSQ CCV in isoform 2. 1 PublicationVSP_038146Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012014 mRNA. Translation: AAY59750.1.
DQ012015 mRNA. Translation: AAY59751.1.
AL138879 Genomic DNA. No translation available.
CCDSiCCDS34475.1. [Q30KQ9-1]
CCDS43473.1. [Q30KQ9-2]
RefSeqiNP_001032586.1. NM_001037497.1. [Q30KQ9-1]
NP_001032817.1. NM_001037728.2. [Q30KQ9-2]
UniGeneiHs.571093.

Genome annotation databases

EnsembliENST00000371148; ENSP00000360190; ENSG00000203970. [Q30KQ9-1]
ENST00000393660; ENSP00000377270; ENSG00000203970. [Q30KQ9-2]
GeneIDi245913.
KEGGihsa:245913.
UCSCiuc003pac.3. human. [Q30KQ9-1]
uc011dwr.2. human. [Q30KQ9-2]

Polymorphism databases

DMDMi84028871.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012014 mRNA. Translation: AAY59750.1 .
DQ012015 mRNA. Translation: AAY59751.1 .
AL138879 Genomic DNA. No translation available.
CCDSi CCDS34475.1. [Q30KQ9-1 ]
CCDS43473.1. [Q30KQ9-2 ]
RefSeqi NP_001032586.1. NM_001037497.1. [Q30KQ9-1 ]
NP_001032817.1. NM_001037728.2. [Q30KQ9-2 ]
UniGenei Hs.571093.

3D structure databases

ProteinModelPortali Q30KQ9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000360190.

Polymorphism databases

DMDMi 84028871.

Proteomic databases

PRIDEi Q30KQ9.

Protocols and materials databases

DNASUi 245913.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371148 ; ENSP00000360190 ; ENSG00000203970 . [Q30KQ9-1 ]
ENST00000393660 ; ENSP00000377270 ; ENSG00000203970 . [Q30KQ9-2 ]
GeneIDi 245913.
KEGGi hsa:245913.
UCSCi uc003pac.3. human. [Q30KQ9-1 ]
uc011dwr.2. human. [Q30KQ9-2 ]

Organism-specific databases

CTDi 245913.
GeneCardsi GC06M049976.
HGNCi HGNC:18091. DEFB110.
HPAi HPA060517.
neXtProti NX_Q30KQ9.
PharmGKBi PA38487.
PA38488.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG133758.
GeneTreei ENSGT00390000006761.
HOGENOMi HOG000112150.
HOVERGENi HBG063273.
InParanoidi Q30KQ9.
OMAi EIRIAYC.
OrthoDBi EOG74N5KS.
PhylomeDBi Q30KQ9.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 245913.
NextBioi 91763.
PROi Q30KQ9.

Gene expression databases

Bgeei Q30KQ9.
CleanExi HS_DEFB111.
Genevestigatori Q30KQ9.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDB110_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ9
Secondary accession number(s): Q30KR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3