Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q30KQ9 (DB110_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 110
Alternative name(s):
Beta-defensin 10
Short name=DEFB-10
Beta-defensin 11
Short name=DEFB-11
Beta-defensin 111
Defensin, beta 110
Defensin, beta 111
Gene names
Name:DEFB110
Synonyms:DEFB10, DEFB11, DEFB111
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length67 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q30KQ9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q30KQ9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     20-67: KKKYPEYGSL...RPGTHCCLQQ → RSNFEPKYRF...CIKWRSQCCV

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 6748Beta-defensin 110
PRO_0000045336

Amino acid modifications

Disulfide bond35 ↔ 63 By similarity
Disulfide bond42 ↔ 56 By similarity
Disulfide bond46 ↔ 64 By similarity

Natural variations

Alternative sequence20 – 6748KKKYP…CCLQQ → RSNFEPKYRFERCEKVRGIC KTFCDDVEYDYGYCIKWRSQ CCV in isoform 2.
VSP_038146

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 923DBCA99BC9B3E9

FASTA678,001
        10         20         30         40         50         60 
MKIQLFFFIL HFWVTILPAK KKYPEYGSLD LRRECRIGNG QCKNQCHENE IRIAYCIRPG 


THCCLQQ 

« Hide

Isoform 2 [UniParc].

Checksum: E03991B1C6F1156F
Show »

FASTA627,672

References

« Hide 'large scale' references
[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012014 mRNA. Translation: AAY59750.1.
DQ012015 mRNA. Translation: AAY59751.1.
AL138879 Genomic DNA. No translation available.
CCDSCCDS34475.1. [Q30KQ9-1]
CCDS43473.1. [Q30KQ9-2]
RefSeqNP_001032586.1. NM_001037497.1. [Q30KQ9-1]
NP_001032817.1. NM_001037728.2. [Q30KQ9-2]
UniGeneHs.571093.

3D structure databases

ProteinModelPortalQ30KQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000360190.

Polymorphism databases

DMDM84028871.

Proteomic databases

PRIDEQ30KQ9.

Protocols and materials databases

DNASU245913.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371148; ENSP00000360190; ENSG00000203970. [Q30KQ9-1]
ENST00000393660; ENSP00000377270; ENSG00000203970. [Q30KQ9-2]
GeneID245913.
KEGGhsa:245913.
UCSCuc003pac.3. human. [Q30KQ9-1]
uc011dwr.2. human. [Q30KQ9-2]

Organism-specific databases

CTD245913.
GeneCardsGC06M049976.
HGNCHGNC:18091. DEFB110.
HPAHPA060517.
neXtProtNX_Q30KQ9.
PharmGKBPA38487.
PA38488.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG133758.
HOGENOMHOG000112150.
HOVERGENHBG063273.
InParanoidQ30KQ9.
OMAEIRIAYC.
OrthoDBEOG74N5KS.
PhylomeDBQ30KQ9.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ30KQ9.
CleanExHS_DEFB111.
GenevestigatorQ30KQ9.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio91763.
PROQ30KQ9.

Entry information

Entry nameDB110_HUMAN
AccessionPrimary (citable) accession number: Q30KQ9
Secondary accession number(s): Q30KR0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM