ID   DB112_HUMAN             Reviewed;         113 AA.
AC   Q30KQ8; Q8NET0;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   08-NOV-2023, entry version 106.
DE   RecName: Full=Beta-defensin 112;
DE   AltName: Full=Beta-defensin 12;
DE            Short=DEFB-12;
DE   AltName: Full=Defensin, beta 112;
DE   Flags: Precursor;
GN   Name=DEFB112; Synonyms=DEFB12;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.
RX   PubMed=11854508; DOI=10.1073/pnas.042692699;
RA   Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P.,
RA   Welsh M.J., Casavant T.L., McCray P.B. Jr.;
RT   "Discovery of five conserved beta-defensin gene clusters using a
RT   computational search strategy.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q30KQ8; O75031: HSF2BP; NbExp=3; IntAct=EBI-17470374, EBI-7116203;
CC       Q30KQ8; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-17470374, EBI-11747707;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012016; AAY59752.1; -; mRNA.
DR   EMBL; AY122469; AAM93911.1; -; mRNA.
DR   RefSeq; NP_001032587.1; NM_001037498.1.
DR   AlphaFoldDB; Q30KQ8; -.
DR   SMR; Q30KQ8; -.
DR   BioGRID; 128840; 17.
DR   IntAct; Q30KQ8; 2.
DR   STRING; 9606.ENSP00000319126; -.
DR   BioMuta; DEFB112; -.
DR   DMDM; 84028873; -.
DR   MassIVE; Q30KQ8; -.
DR   PaxDb; 9606-ENSP00000319126; -.
DR   PeptideAtlas; Q30KQ8; -.
DR   ProteomicsDB; 61580; -.
DR   DNASU; 245915; -.
DR   UCSC; uc011dws.2; human.
DR   AGR; HGNC:18093; -.
DR   GeneCards; DEFB112; -.
DR   HGNC; HGNC:18093; DEFB112.
DR   neXtProt; NX_Q30KQ8; -.
DR   PharmGKB; PA38489; -.
DR   eggNOG; ENOG502TDZN; Eukaryota.
DR   HOGENOM; CLU_176668_0_0_1; -.
DR   InParanoid; Q30KQ8; -.
DR   PhylomeDB; Q30KQ8; -.
DR   TreeFam; TF353195; -.
DR   PathwayCommons; Q30KQ8; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   SignaLink; Q30KQ8; -.
DR   BioGRID-ORCS; 245915; 13 hits in 1101 CRISPR screens.
DR   GenomeRNAi; 245915; -.
DR   Pharos; Q30KQ8; Tdark.
DR   PRO; PR:Q30KQ8; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q30KQ8; Protein.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..?
FT                   /evidence="ECO:0000255"
FT   CHAIN           ?..113
FT                   /note="Beta-defensin 112"
FT                   /id="PRO_0000045338"
FT   DISULFID        54..82
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        65..83
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12991 MW;  53617991C2160524 CRC64;
     MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR WKSCTAIGGR
     CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS VGTQEWYPKD SRH
//