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Q30KQ8

- DB112_HUMAN

UniProt

Q30KQ8 - DB112_HUMAN

Protein

Beta-defensin 112

Gene

DEFB112

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 112
    Alternative name(s):
    Beta-defensin 12
    Short name:
    DEFB-12
    Defensin, beta 112
    Gene namesi
    Name:DEFB112
    Synonyms:DEFB12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18093. DEFB112.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38489.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 113Beta-defensin 112PRO_0000045338
    Signal peptidei1 – ?Sequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 82By similarity
    Disulfide bondi61 ↔ 75By similarity
    Disulfide bondi65 ↔ 83By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ30KQ8.
    PRIDEiQ30KQ8.

    Expressioni

    Gene expression databases

    BgeeiQ30KQ8.
    CleanExiHS_DEFB112.
    GenevestigatoriQ30KQ8.

    Organism-specific databases

    HPAiHPA052048.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000319126.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KQ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG120793.
    HOGENOMiHOG000112151.
    HOVERGENiHBG081407.
    InParanoidiQ30KQ8.
    OMAiLTTICRL.
    OrthoDBiEOG7NGQDV.
    PhylomeDBiQ30KQ8.
    TreeFamiTF353195.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KQ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR    50
    WKSCTAIGGR CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS 100
    VGTQEWYPKD SRH 113
    Length:113
    Mass (Da):12,991
    Last modified:December 6, 2005 - v1
    Checksum:i53617991C2160524
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012016 mRNA. Translation: AAY59752.1.
    AY122469 mRNA. Translation: AAM93911.1.
    CCDSiCCDS34476.1.
    RefSeqiNP_001032587.1. NM_001037498.1.
    UniGeneiHs.571092.

    Genome annotation databases

    EnsembliENST00000322246; ENSP00000319126; ENSG00000180872.
    GeneIDi245915.
    KEGGihsa:245915.
    UCSCiuc011dws.2. human.

    Polymorphism databases

    DMDMi84028873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012016 mRNA. Translation: AAY59752.1 .
    AY122469 mRNA. Translation: AAM93911.1 .
    CCDSi CCDS34476.1.
    RefSeqi NP_001032587.1. NM_001037498.1.
    UniGenei Hs.571092.

    3D structure databases

    ProteinModelPortali Q30KQ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000319126.

    Polymorphism databases

    DMDMi 84028873.

    Proteomic databases

    PaxDbi Q30KQ8.
    PRIDEi Q30KQ8.

    Protocols and materials databases

    DNASUi 245915.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322246 ; ENSP00000319126 ; ENSG00000180872 .
    GeneIDi 245915.
    KEGGi hsa:245915.
    UCSCi uc011dws.2. human.

    Organism-specific databases

    CTDi 245915.
    GeneCardsi GC06M050014.
    HGNCi HGNC:18093. DEFB112.
    HPAi HPA052048.
    neXtProti NX_Q30KQ8.
    PharmGKBi PA38489.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG120793.
    HOGENOMi HOG000112151.
    HOVERGENi HBG081407.
    InParanoidi Q30KQ8.
    OMAi LTTICRL.
    OrthoDBi EOG7NGQDV.
    PhylomeDBi Q30KQ8.
    TreeFami TF353195.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 91771.
    PROi Q30KQ8.

    Gene expression databases

    Bgeei Q30KQ8.
    CleanExi HS_DEFB112.
    Genevestigatori Q30KQ8.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
      Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.

    Entry informationi

    Entry nameiDB112_HUMAN
    AccessioniPrimary (citable) accession number: Q30KQ8
    Secondary accession number(s): Q8NET0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3