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Protein

Beta-defensin 112

Gene

DEFB112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 112
Alternative name(s):
Beta-defensin 12
Short name:
DEFB-12
Defensin, beta 112
Gene namesi
Name:DEFB112
Synonyms:DEFB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18093. DEFB112.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38489.

Polymorphism and mutation databases

BioMutaiDEFB112.
DMDMi84028873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 113Beta-defensin 112PRO_0000045338
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 82By similarity
Disulfide bondi61 ↔ 75By similarity
Disulfide bondi65 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ8.
PRIDEiQ30KQ8.

Expressioni

Gene expression databases

BgeeiQ30KQ8.
CleanExiHS_DEFB112.

Organism-specific databases

HPAiHPA052048.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319126.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG120793.
GeneTreeiENSGT00410000029004.
HOGENOMiHOG000112151.
HOVERGENiHBG081407.
InParanoidiQ30KQ8.
OMAiLTTICRL.
OrthoDBiEOG7NGQDV.
PhylomeDBiQ30KQ8.
TreeFamiTF353195.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR
60 70 80 90 100
WKSCTAIGGR CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS
110
VGTQEWYPKD SRH
Length:113
Mass (Da):12,991
Last modified:December 6, 2005 - v1
Checksum:i53617991C2160524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA. Translation: AAY59752.1.
AY122469 mRNA. Translation: AAM93911.1.
CCDSiCCDS34476.1.
RefSeqiNP_001032587.1. NM_001037498.1.
UniGeneiHs.571092.

Genome annotation databases

EnsembliENST00000322246; ENSP00000319126; ENSG00000180872.
GeneIDi245915.
KEGGihsa:245915.
UCSCiuc011dws.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA. Translation: AAY59752.1.
AY122469 mRNA. Translation: AAM93911.1.
CCDSiCCDS34476.1.
RefSeqiNP_001032587.1. NM_001037498.1.
UniGeneiHs.571092.

3D structure databases

ProteinModelPortaliQ30KQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319126.

Polymorphism and mutation databases

BioMutaiDEFB112.
DMDMi84028873.

Proteomic databases

PaxDbiQ30KQ8.
PRIDEiQ30KQ8.

Protocols and materials databases

DNASUi245915.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322246; ENSP00000319126; ENSG00000180872.
GeneIDi245915.
KEGGihsa:245915.
UCSCiuc011dws.2. human.

Organism-specific databases

CTDi245915.
GeneCardsiGC06M050014.
HGNCiHGNC:18093. DEFB112.
HPAiHPA052048.
neXtProtiNX_Q30KQ8.
PharmGKBiPA38489.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG120793.
GeneTreeiENSGT00410000029004.
HOGENOMiHOG000112151.
HOVERGENiHBG081407.
InParanoidiQ30KQ8.
OMAiLTTICRL.
OrthoDBiEOG7NGQDV.
PhylomeDBiQ30KQ8.
TreeFamiTF353195.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii245915.
NextBioi91771.
PROiQ30KQ8.

Gene expression databases

BgeeiQ30KQ8.
CleanExiHS_DEFB112.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.

Entry informationi

Entry nameiDB112_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.