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Q30KQ8 (DB112_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 112
Alternative name(s):
Beta-defensin 12
Short name=DEFB-12
Defensin, beta 112
Gene names
Name:DEFB112
Synonyms:DEFB12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length113 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – ? Potential
Chain? – 113Beta-defensin 112PRO_0000045338

Amino acid modifications

Disulfide bond54 ↔ 82 By similarity
Disulfide bond61 ↔ 75 By similarity
Disulfide bond65 ↔ 83 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30KQ8 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 53617991C2160524

FASTA11312,991
        10         20         30         40         50         60 
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR WKSCTAIGGR 

        70         80         90        100        110 
CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS VGTQEWYPKD SRH 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012016 mRNA. Translation: AAY59752.1.
AY122469 mRNA. Translation: AAM93911.1.
CCDSCCDS34476.1.
RefSeqNP_001032587.1. NM_001037498.1.
UniGeneHs.571092.

3D structure databases

ProteinModelPortalQ30KQ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000319126.

Polymorphism databases

DMDM84028873.

Proteomic databases

PaxDbQ30KQ8.
PRIDEQ30KQ8.

Protocols and materials databases

DNASU245915.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322246; ENSP00000319126; ENSG00000180872.
GeneID245915.
KEGGhsa:245915.
UCSCuc011dws.2. human.

Organism-specific databases

CTD245915.
GeneCardsGC06M050014.
HGNCHGNC:18093. DEFB112.
HPAHPA052048.
neXtProtNX_Q30KQ8.
PharmGKBPA38489.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG120793.
HOGENOMHOG000112151.
HOVERGENHBG081407.
InParanoidQ30KQ8.
OMALTTICRL.
OrthoDBEOG7NGQDV.
PhylomeDBQ30KQ8.
TreeFamTF353195.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeQ30KQ8.
CleanExHS_DEFB112.
GenevestigatorQ30KQ8.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio91771.
PROQ30KQ8.

Entry information

Entry nameDB112_HUMAN
AccessionPrimary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM