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Protein

Beta-defensin 112

Gene

DEFB112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 112
Alternative name(s):
Beta-defensin 12
Short name:
DEFB-12
Defensin, beta 112
Gene namesi
Name:DEFB112
Synonyms:DEFB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18093. DEFB112.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38489.

Polymorphism and mutation databases

BioMutaiDEFB112.
DMDMi84028873.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000045338? – 113Beta-defensin 112
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 82By similarity
Disulfide bondi61 ↔ 75By similarity
Disulfide bondi65 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ8.
PRIDEiQ30KQ8.

Expressioni

Gene expression databases

BgeeiENSG00000180872.
CleanExiHS_DEFB112.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319126.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ8.
SMRiQ30KQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3MJ. Eukaryota.
ENOG4111ABI. LUCA.
GeneTreeiENSGT00410000029004.
HOGENOMiHOG000112151.
HOVERGENiHBG081407.
InParanoidiQ30KQ8.
OMAiSEGHHIT.
OrthoDBiEOG091G0V7Y.
PhylomeDBiQ30KQ8.
TreeFamiTF353195.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD736990. PD736990. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR
60 70 80 90 100
WKSCTAIGGR CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS
110
VGTQEWYPKD SRH
Length:113
Mass (Da):12,991
Last modified:December 6, 2005 - v1
Checksum:i53617991C2160524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA. Translation: AAY59752.1.
AY122469 mRNA. Translation: AAM93911.1.
CCDSiCCDS34476.1.
RefSeqiNP_001032587.1. NM_001037498.1.
UniGeneiHs.571092.

Genome annotation databases

EnsembliENST00000322246; ENSP00000319126; ENSG00000180872.
GeneIDi245915.
KEGGihsa:245915.
UCSCiuc011dws.2. human.

Similar proteinsi

Entry informationi

Entry nameiDB112_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families