Q30KQ8 (DB112_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 112

Alternative name(s):
Beta-defensin 12
Short name=DEFB-12
Defensin, beta 112

Gene names

Name:	DEFB112
Synonyms:	DEFB12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 113		Beta-defensin 112		PRO_0000045338
Amino acid modifications
	Disulfide bond	54 ↔ 82		By similarity
	Disulfide bond	61 ↔ 75		By similarity
	Disulfide bond	65 ↔ 83		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30KQ8 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 53617991C2160524	FASTA	113	12,991
	10 20 30 40 50 60 MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR WKSCTAIGGR 70 80 90 100 110 CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS VGTQEWYPKD SRH

References

[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Discovery of five conserved beta-defensin gene clusters using a computational search strategy." Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr. Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012016 mRNA. Translation: AAY59752.1. AY122469 mRNA. Translation: AAM93911.1.
IPI	IPI00302567.
RefSeq	NP_001032587.1. NM_001037498.1.
UniGene	Hs.571092.
3D structure databases
ProteinModelPortal	Q30KQ8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000319126.
Polymorphism databases
DMDM	84028873.
Proteomic databases
PaxDb	Q30KQ8.
PRIDE	Q30KQ8.
Protocols and materials databases
DNASU	245915.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000322246; ENSP00000319126; ENSG00000180872.
GeneID	245915.
KEGG	hsa:245915.
UCSC	uc011dws.2. human.
Organism-specific databases
CTD	245915.
GeneCards	GC06M050014.
HGNC	HGNC:18093. DEFB112.
HPA	HPA052048.
neXtProt	NX_Q30KQ8.
PharmGKB	PA38489.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG120793.
HOGENOM	HOG000112151.
HOVERGEN	HBG081407.
InParanoid	Q30KQ8.
OMA	LTTICRL.
OrthoDB	EOG4J6RSJ.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Bgee	Q30KQ8.
CleanEx	HS_DEFB112.
Genevestigator	Q30KQ8.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91771.

Entry information

Entry name

DB112_HUMAN

Accession

Primary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	May 1, 2013
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.