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Protein

Beta-defensin 112

Gene

DEFB112

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 112
Alternative name(s):
Beta-defensin 12
Short name:
DEFB-12
Defensin, beta 112
Gene namesi
Name:DEFB112
Synonyms:DEFB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000180872.4
HGNCiHGNC:18093 DEFB112
neXtProtiNX_Q30KQ8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38489

Polymorphism and mutation databases

BioMutaiDEFB112
DMDMi84028873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000045338? – 113Beta-defensin 112
Signal peptidei1 – ?Sequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 82By similarity
Disulfide bondi61 ↔ 75By similarity
Disulfide bondi65 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ8
PRIDEiQ30KQ8
ProteomicsDBi61580

Expressioni

Gene expression databases

BgeeiENSG00000180872
CleanExiHS_DEFB112

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319126

Structurei

3D structure databases

ProteinModelPortaliQ30KQ8
SMRiQ30KQ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3MJ Eukaryota
ENOG4111ABI LUCA
GeneTreeiENSGT00410000029004
HOGENOMiHOG000112151
HOVERGENiHBG081407
InParanoidiQ30KQ8
OMAiSEGHHIT
OrthoDBiEOG091G0V7Y
PhylomeDBiQ30KQ8
TreeFamiTF353195

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD736990 PD736990, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR
60 70 80 90 100
WKSCTAIGGR CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS
110
VGTQEWYPKD SRH
Length:113
Mass (Da):12,991
Last modified:December 6, 2005 - v1
Checksum:i53617991C2160524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA Translation: AAY59752.1
AY122469 mRNA Translation: AAM93911.1
CCDSiCCDS34476.1
RefSeqiNP_001032587.1, NM_001037498.1
UniGeneiHs.571092

Genome annotation databases

EnsembliENST00000322246; ENSP00000319126; ENSG00000180872
GeneIDi245915
KEGGihsa:245915
UCSCiuc011dws.2 human

Similar proteinsi

Entry informationi

Entry nameiDB112_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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