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Q30KQ8

- DB112_HUMAN

UniProt

Q30KQ8 - DB112_HUMAN

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Protein

Beta-defensin 112

Gene

DEFB112

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 112
Alternative name(s):
Beta-defensin 12
Short name:
DEFB-12
Defensin, beta 112
Gene namesi
Name:DEFB112
Synonyms:DEFB12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18093. DEFB112.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38489.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 113Beta-defensin 112PRO_0000045338
Signal peptidei1 – ?Sequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 82By similarity
Disulfide bondi61 ↔ 75By similarity
Disulfide bondi65 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ8.
PRIDEiQ30KQ8.

Expressioni

Gene expression databases

BgeeiQ30KQ8.
CleanExiHS_DEFB112.
GenevestigatoriQ30KQ8.

Organism-specific databases

HPAiHPA052048.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319126.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG120793.
GeneTreeiENSGT00410000029004.
HOGENOMiHOG000112151.
HOVERGENiHBG081407.
InParanoidiQ30KQ8.
OMAiLTTICRL.
OrthoDBiEOG7NGQDV.
PhylomeDBiQ30KQ8.
TreeFamiTF353195.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLTTICRL KLEKMYSKTN TSSTIFEKAR HGTEKISTAR SEGHHITFSR
60 70 80 90 100
WKSCTAIGGR CKNQCDDSEF RISYCARPTT HCCVTECDPT DPNNWIPKDS
110
VGTQEWYPKD SRH
Length:113
Mass (Da):12,991
Last modified:December 6, 2005 - v1
Checksum:i53617991C2160524
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA. Translation: AAY59752.1.
AY122469 mRNA. Translation: AAM93911.1.
CCDSiCCDS34476.1.
RefSeqiNP_001032587.1. NM_001037498.1.
UniGeneiHs.571092.

Genome annotation databases

EnsembliENST00000322246; ENSP00000319126; ENSG00000180872.
GeneIDi245915.
KEGGihsa:245915.
UCSCiuc011dws.2. human.

Polymorphism databases

DMDMi84028873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012016 mRNA. Translation: AAY59752.1 .
AY122469 mRNA. Translation: AAM93911.1 .
CCDSi CCDS34476.1.
RefSeqi NP_001032587.1. NM_001037498.1.
UniGenei Hs.571092.

3D structure databases

ProteinModelPortali Q30KQ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000319126.

Polymorphism databases

DMDMi 84028873.

Proteomic databases

PaxDbi Q30KQ8.
PRIDEi Q30KQ8.

Protocols and materials databases

DNASUi 245915.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000322246 ; ENSP00000319126 ; ENSG00000180872 .
GeneIDi 245915.
KEGGi hsa:245915.
UCSCi uc011dws.2. human.

Organism-specific databases

CTDi 245915.
GeneCardsi GC06M050014.
HGNCi HGNC:18093. DEFB112.
HPAi HPA052048.
neXtProti NX_Q30KQ8.
PharmGKBi PA38489.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG120793.
GeneTreei ENSGT00410000029004.
HOGENOMi HOG000112151.
HOVERGENi HBG081407.
InParanoidi Q30KQ8.
OMAi LTTICRL.
OrthoDBi EOG7NGQDV.
PhylomeDBi Q30KQ8.
TreeFami TF353195.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 245915.
NextBioi 91771.
PROi Q30KQ8.

Gene expression databases

Bgeei Q30KQ8.
CleanExi HS_DEFB112.
Genevestigatori Q30KQ8.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Discovery of five conserved beta-defensin gene clusters using a computational search strategy."
    Schutte B.C., Mitros J.P., Bartlett J.A., Walters J.D., Jia H.P., Welsh M.J., Casavant T.L., McCray P.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 99:2129-2133(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-73.

Entry informationi

Entry nameiDB112_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ8
Secondary accession number(s): Q8NET0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3