ID   DB113_HUMAN             Reviewed;          82 AA.
AC   Q30KQ7;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=Beta-defensin 113;
DE   AltName: Full=Beta-defensin 13;
DE            Short=DEFB-13;
DE   AltName: Full=Defensin, beta 113;
DE   Flags: Precursor;
GN   Name=DEFB113; Synonyms=DEFB13;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
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DR   EMBL; DQ012017; AAY59753.1; -; mRNA.
DR   CCDS; CCDS43472.1; -.
DR   RefSeq; NP_001032818.1; NM_001037729.1.
DR   AlphaFoldDB; Q30KQ7; -.
DR   SMR; Q30KQ7; -.
DR   STRING; 9606.ENSP00000381703; -.
DR   PhosphoSitePlus; Q30KQ7; -.
DR   BioMuta; DEFB113; -.
DR   PaxDb; 9606-ENSP00000381703; -.
DR   Antibodypedia; 64300; 16 antibodies from 1 providers.
DR   DNASU; 245927; -.
DR   Ensembl; ENST00000398718.1; ENSP00000381703.1; ENSG00000214642.1.
DR   GeneID; 245927; -.
DR   KEGG; hsa:245927; -.
DR   MANE-Select; ENST00000398718.1; ENSP00000381703.1; NM_001037729.1; NP_001032818.1.
DR   UCSC; uc011dwq.2; human.
DR   AGR; HGNC:18094; -.
DR   CTD; 245927; -.
DR   GeneCards; DEFB113; -.
DR   HGNC; HGNC:18094; DEFB113.
DR   HPA; ENSG00000214642; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KQ7; -.
DR   PharmGKB; PA38490; -.
DR   VEuPathDB; HostDB:ENSG00000214642; -.
DR   eggNOG; ENOG502TEDM; Eukaryota.
DR   GeneTree; ENSGT00400000023306; -.
DR   HOGENOM; CLU_169780_0_0_1; -.
DR   InParanoid; Q30KQ7; -.
DR   OMA; GACKPEC; -.
DR   OrthoDB; 5261764at2759; -.
DR   PhylomeDB; Q30KQ7; -.
DR   PathwayCommons; Q30KQ7; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   SignaLink; Q30KQ7; -.
DR   BioGRID-ORCS; 245927; 8 hits in 1138 CRISPR screens.
DR   GenomeRNAi; 245927; -.
DR   Pharos; Q30KQ7; Tdark.
DR   PRO; PR:Q30KQ7; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q30KQ7; Protein.
DR   Bgee; ENSG00000214642; Expressed in cell and 14 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR39411; BETA-DEFENSIN 113; 1.
DR   PANTHER; PTHR39411:SF1; BETA-DEFENSIN 113; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..82
FT                   /note="Beta-defensin 113"
FT                   /id="PRO_0000045340"
FT   DISULFID        35..61
FT                   /evidence="ECO:0000250"
FT   DISULFID        42..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..62
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9640 MW;  F7713A910DDEF697 CRC64;
     MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE YVYYYCNVNP
     CCAVWEYQKP IINKITSKLH QK
//