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Q30KQ7

- DB113_HUMAN

UniProt

Q30KQ7 - DB113_HUMAN

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Protein

Beta-defensin 113

Gene
DEFB113, DEFB13
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Has antibacterial activity By similarity.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 113
Alternative name(s):
Beta-defensin 13
Short name:
DEFB-13
Defensin, beta 113
Gene namesi
Name:DEFB113
Synonyms:DEFB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:18094. DEFB113.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed predictionAdd
BLAST
Chaini17 – 8266Beta-defensin 113PRO_0000045340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 61 By similarity
Disulfide bondi42 ↔ 56 By similarity
Disulfide bondi46 ↔ 62 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KQ7.

Expressioni

Gene expression databases

CleanExiHS_DEFB113.
GenevestigatoriQ30KQ7.

Organism-specific databases

HPAiHPA052327.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ7.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG134180.
HOGENOMiHOG000112152.
HOVERGENiHBG081408.
InParanoidiQ30KQ7.
OMAiCCVVREY.
OrthoDBiEOG7QVM5C.
PhylomeDBiQ30KQ7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ7-1 [UniParc]FASTAAdd to Basket

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MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE   50
YVYYYCNVNP CCAVWEYQKP IINKITSKLH QK 82
Length:82
Mass (Da):9,640
Last modified:December 6, 2005 - v1
Checksum:iF7713A910DDEF697
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012017 mRNA. Translation: AAY59753.1.
CCDSiCCDS43472.1.
RefSeqiNP_001032818.1. NM_001037729.1.
UniGeneiHs.582789.

Genome annotation databases

EnsembliENST00000398718; ENSP00000381703; ENSG00000214642.
GeneIDi245927.
KEGGihsa:245927.
UCSCiuc011dwq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012017 mRNA. Translation: AAY59753.1 .
CCDSi CCDS43472.1.
RefSeqi NP_001032818.1. NM_001037729.1.
UniGenei Hs.582789.

3D structure databases

ProteinModelPortali Q30KQ7.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q30KQ7.

Protocols and materials databases

DNASUi 245927.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398718 ; ENSP00000381703 ; ENSG00000214642 .
GeneIDi 245927.
KEGGi hsa:245927.
UCSCi uc011dwq.2. human.

Organism-specific databases

CTDi 245927.
GeneCardsi GC06M049936.
HGNCi HGNC:18094. DEFB113.
HPAi HPA052327.
neXtProti NX_Q30KQ7.
PharmGKBi PA38490.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG134180.
HOGENOMi HOG000112152.
HOVERGENi HBG081408.
InParanoidi Q30KQ7.
OMAi CCVVREY.
OrthoDBi EOG7QVM5C.
PhylomeDBi Q30KQ7.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

NextBioi 91775.
PROi Q30KQ7.

Gene expression databases

CleanExi HS_DEFB113.
Genevestigatori Q30KQ7.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDB113_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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