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Q30KQ7 (DB113_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 113
Alternative name(s):
Beta-defensin 13
Short name=DEFB-13
Defensin, beta 113
Gene names
Name:DEFB113
Synonyms:DEFB13
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length82 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the beta-defensin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 8266Beta-defensin 113
PRO_0000045340

Amino acid modifications

Disulfide bond35 ↔ 61 By similarity
Disulfide bond42 ↔ 56 By similarity
Disulfide bond46 ↔ 62 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30KQ7 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: F7713A910DDEF697

FASTA829,640
        10         20         30         40         50         60 
MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE YVYYYCNVNP 

        70         80 
CCAVWEYQKP IINKITSKLH QK 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012017 mRNA. Translation: AAY59753.1.
CCDSCCDS43472.1.
RefSeqNP_001032818.1. NM_001037729.1.
UniGeneHs.582789.

3D structure databases

ProteinModelPortalQ30KQ7.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ30KQ7.

Protocols and materials databases

DNASU245927.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398718; ENSP00000381703; ENSG00000214642.
GeneID245927.
KEGGhsa:245927.
UCSCuc011dwq.2. human.

Organism-specific databases

CTD245927.
GeneCardsGC06M049936.
HGNCHGNC:18094. DEFB113.
HPAHPA052327.
neXtProtNX_Q30KQ7.
PharmGKBPA38490.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG134180.
HOGENOMHOG000112152.
HOVERGENHBG081408.
InParanoidQ30KQ7.
OMACCVVREY.
OrthoDBEOG7QVM5C.
PhylomeDBQ30KQ7.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_DEFB113.
GenevestigatorQ30KQ7.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio91775.
PROQ30KQ7.

Entry information

Entry nameDB113_HUMAN
AccessionPrimary (citable) accession number: Q30KQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM