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Q30KQ7

- DB113_HUMAN

UniProt

Q30KQ7 - DB113_HUMAN

Protein

Beta-defensin 113

Gene

DEFB113

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.By similarity

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 113
    Alternative name(s):
    Beta-defensin 13
    Short name:
    DEFB-13
    Defensin, beta 113
    Gene namesi
    Name:DEFB113
    Synonyms:DEFB13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18094. DEFB113.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38490.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 8266Beta-defensin 113PRO_0000045340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi35 ↔ 61By similarity
    Disulfide bondi42 ↔ 56By similarity
    Disulfide bondi46 ↔ 62By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ30KQ7.

    Expressioni

    Gene expression databases

    CleanExiHS_DEFB113.
    GenevestigatoriQ30KQ7.

    Organism-specific databases

    HPAiHPA052327.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG134180.
    HOGENOMiHOG000112152.
    HOVERGENiHBG081408.
    InParanoidiQ30KQ7.
    OMAiCCVVREY.
    OrthoDBiEOG7QVM5C.
    PhylomeDBiQ30KQ7.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KQ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE   50
    YVYYYCNVNP CCAVWEYQKP IINKITSKLH QK 82
    Length:82
    Mass (Da):9,640
    Last modified:December 6, 2005 - v1
    Checksum:iF7713A910DDEF697
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012017 mRNA. Translation: AAY59753.1.
    CCDSiCCDS43472.1.
    RefSeqiNP_001032818.1. NM_001037729.1.
    UniGeneiHs.582789.

    Genome annotation databases

    EnsembliENST00000398718; ENSP00000381703; ENSG00000214642.
    GeneIDi245927.
    KEGGihsa:245927.
    UCSCiuc011dwq.2. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012017 mRNA. Translation: AAY59753.1 .
    CCDSi CCDS43472.1.
    RefSeqi NP_001032818.1. NM_001037729.1.
    UniGenei Hs.582789.

    3D structure databases

    ProteinModelPortali Q30KQ7.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q30KQ7.

    Protocols and materials databases

    DNASUi 245927.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398718 ; ENSP00000381703 ; ENSG00000214642 .
    GeneIDi 245927.
    KEGGi hsa:245927.
    UCSCi uc011dwq.2. human.

    Organism-specific databases

    CTDi 245927.
    GeneCardsi GC06M049936.
    HGNCi HGNC:18094. DEFB113.
    HPAi HPA052327.
    neXtProti NX_Q30KQ7.
    PharmGKBi PA38490.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG134180.
    HOGENOMi HOG000112152.
    HOVERGENi HBG081408.
    InParanoidi Q30KQ7.
    OMAi CCVVREY.
    OrthoDBi EOG7QVM5C.
    PhylomeDBi Q30KQ7.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 91775.
    PROi Q30KQ7.

    Gene expression databases

    CleanExi HS_DEFB113.
    Genevestigatori Q30KQ7.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDB113_HUMAN
    AccessioniPrimary (citable) accession number: Q30KQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3