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Protein

Beta-defensin 113

Gene

DEFB113

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 113
Alternative name(s):
Beta-defensin 13
Short name:
DEFB-13
Defensin, beta 113
Gene namesi
Name:DEFB113
Synonyms:DEFB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18094. DEFB113.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 8266Beta-defensin 113PRO_0000045340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi35 ↔ 61By similarity
Disulfide bondi42 ↔ 56By similarity
Disulfide bondi46 ↔ 62By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KQ7.

Expressioni

Gene expression databases

CleanExiHS_DEFB113.
GenevestigatoriQ30KQ7.

Organism-specific databases

HPAiHPA052327.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG134180.
GeneTreeiENSGT00400000023306.
HOGENOMiHOG000112152.
HOVERGENiHBG081408.
InParanoidiQ30KQ7.
OMAiMKILCIF.
OrthoDBiEOG7QVM5C.
PhylomeDBiQ30KQ7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE
60 70 80
YVYYYCNVNP CCAVWEYQKP IINKITSKLH QK
Length:82
Mass (Da):9,640
Last modified:December 5, 2005 - v1
Checksum:iF7713A910DDEF697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012017 mRNA. Translation: AAY59753.1.
CCDSiCCDS43472.1.
RefSeqiNP_001032818.1. NM_001037729.1.
UniGeneiHs.582789.

Genome annotation databases

EnsembliENST00000398718; ENSP00000381703; ENSG00000214642.
GeneIDi245927.
KEGGihsa:245927.
UCSCiuc011dwq.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012017 mRNA. Translation: AAY59753.1.
CCDSiCCDS43472.1.
RefSeqiNP_001032818.1. NM_001037729.1.
UniGeneiHs.582789.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ30KQ7.

Protocols and materials databases

DNASUi245927.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398718; ENSP00000381703; ENSG00000214642.
GeneIDi245927.
KEGGihsa:245927.
UCSCiuc011dwq.2. human.

Organism-specific databases

CTDi245927.
GeneCardsiGC06M049936.
HGNCiHGNC:18094. DEFB113.
HPAiHPA052327.
neXtProtiNX_Q30KQ7.
PharmGKBiPA38490.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG134180.
GeneTreeiENSGT00400000023306.
HOGENOMiHOG000112152.
HOVERGENiHBG081408.
InParanoidiQ30KQ7.
OMAiMKILCIF.
OrthoDBiEOG7QVM5C.
PhylomeDBiQ30KQ7.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii245927.
NextBioi91775.
PROiQ30KQ7.

Gene expression databases

CleanExiHS_DEFB113.
GenevestigatoriQ30KQ7.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDB113_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 19, 2005
Last sequence update: December 5, 2005
Last modified: March 31, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.