Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-defensin 113

Gene

DEFB113

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 113
Alternative name(s):
Beta-defensin 13
Short name:
DEFB-13
Defensin, beta 113
Gene namesi
Name:DEFB113
Synonyms:DEFB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000214642.1.
HGNCiHGNC:18094. DEFB113.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38490.

Polymorphism and mutation databases

BioMutaiDEFB113.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000004534017 – 82Beta-defensin 113Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 61By similarity
Disulfide bondi42 ↔ 56By similarity
Disulfide bondi46 ↔ 62By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ7.
PRIDEiQ30KQ7.

PTM databases

PhosphoSitePlusiQ30KQ7.

Expressioni

Gene expression databases

BgeeiENSG00000214642.
CleanExiHS_DEFB113.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381703.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ7.
SMRiQ30KQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3K8. Eukaryota.
ENOG411196D. LUCA.
GeneTreeiENSGT00400000023306.
HOGENOMiHOG000112152.
HOVERGENiHBG081408.
InParanoidiQ30KQ7.
OMAiMKILCIF.
OrthoDBiEOG091G1180.
PhylomeDBiQ30KQ7.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE
60 70 80
YVYYYCNVNP CCAVWEYQKP IINKITSKLH QK
Length:82
Mass (Da):9,640
Last modified:December 6, 2005 - v1
Checksum:iF7713A910DDEF697
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012017 mRNA. Translation: AAY59753.1.
CCDSiCCDS43472.1.
RefSeqiNP_001032818.1. NM_001037729.1.
UniGeneiHs.582789.

Genome annotation databases

EnsembliENST00000398718; ENSP00000381703; ENSG00000214642.
GeneIDi245927.
KEGGihsa:245927.
UCSCiuc011dwq.2. human.

Similar proteinsi

Entry informationi

Entry nameiDB113_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 27, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families