Q30KQ7 (DB113_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 113

Alternative name(s):
Beta-defensin 13
Short name=DEFB-13
Defensin, beta 113

Gene names

Name:	DEFB113
Synonyms:	DEFB13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	82 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity By similarity.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the beta-defensin family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 82	66	Beta-defensin 113		PRO_0000045340
Amino acid modifications
	Disulfide bond	35 ↔ 61		By similarity
	Disulfide bond	42 ↔ 56		By similarity
	Disulfide bond	46 ↔ 62		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30KQ7 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: F7713A910DDEF697	FASTA	82	9,640
	10 20 30 40 50 60 MKILCIFLTF VFTVSCGPSV PQKKTREVAE RKRECQLVRG ACKPECNSWE YVYYYCNVNP 70 80 CCAVWEYQKP IINKITSKLH QK

References

[1]

"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012017 mRNA. Translation: AAY59753.1.
IPI	IPI00655551.
RefSeq	NP_001032818.1. NM_001037729.1.
UniGene	Hs.582789.
3D structure databases
ProteinModelPortal	Q30KQ7.
ModBase	Search...
Polymorphism databases
DMDM	84028875.
Proteomic databases
PRIDE	Q30KQ7.
Protocols and materials databases
DNASU	245927.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398718; ENSP00000381703; ENSG00000214642.
GeneID	245927.
KEGG	hsa:245927.
UCSC	uc011dwq.2. human.
Organism-specific databases
CTD	245927.
GeneCards	GC06M049936.
HGNC	HGNC:18094. DEFB113.
HPA	HPA052327.
neXtProt	NX_Q30KQ7.
PharmGKB	PA38490.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG134180.
HOGENOM	HOG000112152.
HOVERGEN	HBG081408.
InParanoid	Q30KQ7.
OMA	FTVSCGP.
OrthoDB	EOG4DFPQ4.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
CleanEx	HS_DEFB113.
Genevestigator	Q30KQ7.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91775.

Entry information

Entry name

DB113_HUMAN

Accession

Primary (citable) accession number: Q30KQ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	March 6, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.