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Protein

Beta-defensin 115

Gene

DEFB115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 115
Alternative name(s):
Beta-defensin 15
Short name:
DEFB-15
Defensin, beta 115
Gene namesi
Name:DEFB115
Synonyms:DEFB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18096. DEFB115.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38492.

Polymorphism and mutation databases

BioMutaiDEFB115.
DMDMi84028877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence analysisAdd
BLAST
Chaini28 – 8861Beta-defensin 115PRO_0000045343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi38 ↔ 65By similarity
Disulfide bondi45 ↔ 59By similarity
Disulfide bondi49 ↔ 66By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ5.
PRIDEiQ30KQ5.

PTM databases

iPTMnetiQ30KQ5.
PhosphoSiteiQ30KQ5.

Expressioni

Gene expression databases

CleanExiHS_DEFB115.

Organism-specific databases

HPAiHPA053160.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383398.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JK91. Eukaryota.
ENOG41118U6. LUCA.
GeneTreeiENSGT00400000023200.
HOGENOMiHOG000112154.
HOVERGENiHBG081410.
InParanoidiQ30KQ5.
OMAiRCRKSCK.
OrthoDBiEOG091G15HH.
PhylomeDBiQ30KQ5.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPDHFSPLS GDIKLSVLAL VVLVVLAQTA PDGWIRRCYY GTGRCRKSCK
60 70 80
EIERKKEKCG EKHICCVPKE KDKLSHIHDQ KETSELYI
Length:88
Mass (Da):10,071
Last modified:December 6, 2005 - v1
Checksum:i9E4437B69A9121CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012019 mRNA. Translation: AAY59755.1.
AL121723 Genomic DNA. No translation available.
CCDSiCCDS42859.1.
RefSeqiNP_001032819.1. NM_001037730.1.
UniGeneiHs.580793.

Genome annotation databases

EnsembliENST00000400552; ENSP00000383398; ENSG00000215547.
GeneIDi245929.
KEGGihsa:245929.
UCSCiuc002wvp.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012019 mRNA. Translation: AAY59755.1.
AL121723 Genomic DNA. No translation available.
CCDSiCCDS42859.1.
RefSeqiNP_001032819.1. NM_001037730.1.
UniGeneiHs.580793.

3D structure databases

ProteinModelPortaliQ30KQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000383398.

PTM databases

iPTMnetiQ30KQ5.
PhosphoSiteiQ30KQ5.

Polymorphism and mutation databases

BioMutaiDEFB115.
DMDMi84028877.

Proteomic databases

PaxDbiQ30KQ5.
PRIDEiQ30KQ5.

Protocols and materials databases

DNASUi245929.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400552; ENSP00000383398; ENSG00000215547.
GeneIDi245929.
KEGGihsa:245929.
UCSCiuc002wvp.1. human.

Organism-specific databases

CTDi245929.
GeneCardsiDEFB115.
HGNCiHGNC:18096. DEFB115.
HPAiHPA053160.
neXtProtiNX_Q30KQ5.
PharmGKBiPA38492.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JK91. Eukaryota.
ENOG41118U6. LUCA.
GeneTreeiENSGT00400000023200.
HOGENOMiHOG000112154.
HOVERGENiHBG081410.
InParanoidiQ30KQ5.
OMAiRCRKSCK.
OrthoDBiEOG091G15HH.
PhylomeDBiQ30KQ5.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii245929.
PROiQ30KQ5.

Gene expression databases

CleanExiHS_DEFB115.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiDB115_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.