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Protein

Beta-defensin 115

Gene

DEFB115

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 115
Alternative name(s):
Beta-defensin 15
Short name:
DEFB-15
Defensin, beta 115
Gene namesi
Name:DEFB115
Synonyms:DEFB15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000215547.1.
HGNCiHGNC:18096. DEFB115.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38492.

Polymorphism and mutation databases

BioMutaiDEFB115.
DMDMi84028877.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000004534328 – 88Beta-defensin 115Add BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 65By similarity
Disulfide bondi45 ↔ 59By similarity
Disulfide bondi49 ↔ 66By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ5.
PRIDEiQ30KQ5.

PTM databases

iPTMnetiQ30KQ5.
PhosphoSitePlusiQ30KQ5.

Expressioni

Gene expression databases

BgeeiENSG00000215547.
CleanExiHS_DEFB115.

Organism-specific databases

HPAiHPA053160.

Interactioni

Protein-protein interaction databases

IntActiQ30KQ5. 2 interactors.
STRINGi9606.ENSP00000383398.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ5.
SMRiQ30KQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JK91. Eukaryota.
ENOG41118U6. LUCA.
GeneTreeiENSGT00400000023200.
HOGENOMiHOG000112154.
HOVERGENiHBG081410.
InParanoidiQ30KQ5.
OMAiRCRKSCK.
OrthoDBiEOG091G15HH.
PhylomeDBiQ30KQ5.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPDHFSPLS GDIKLSVLAL VVLVVLAQTA PDGWIRRCYY GTGRCRKSCK
60 70 80
EIERKKEKCG EKHICCVPKE KDKLSHIHDQ KETSELYI
Length:88
Mass (Da):10,071
Last modified:December 6, 2005 - v1
Checksum:i9E4437B69A9121CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012019 mRNA. Translation: AAY59755.1.
AL121723 Genomic DNA. No translation available.
CCDSiCCDS42859.1.
RefSeqiNP_001032819.1. NM_001037730.1.
UniGeneiHs.580793.

Genome annotation databases

EnsembliENST00000400552; ENSP00000383398; ENSG00000215547.
GeneIDi245929.
KEGGihsa:245929.
UCSCiuc002wvp.1. human.

Similar proteinsi

Entry informationi

Entry nameiDB115_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 27, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families