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Protein

Beta-defensin 116

Gene

DEFB116

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 116
Alternative name(s):
Beta-defensin 16
Short name:
DEFB-16
Defensin, beta 116
Gene namesi
Name:DEFB116
Synonyms:DEFB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000215545.1
HGNCiHGNC:18097 DEFB116
neXtProtiNX_Q30KQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38493

Polymorphism and mutation databases

BioMutaiDEFB116
DMDMi84028878

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000004534424 – 102Beta-defensin 116Add BLAST79

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi40 ↔ 67By similarity
Disulfide bondi47 ↔ 61By similarity
Disulfide bondi51 ↔ 68By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ4
PeptideAtlasiQ30KQ4
PRIDEiQ30KQ4
ProteomicsDBi61576

PTM databases

iPTMnetiQ30KQ4
PhosphoSitePlusiQ30KQ4

Expressioni

Gene expression databases

BgeeiENSG00000215545
CleanExiHS_DEFB116

Organism-specific databases

HPAiHPA047430

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000383396

Structurei

3D structure databases

ProteinModelPortaliQ30KQ4
SMRiQ30KQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4RG Eukaryota
ENOG41119R3 LUCA
GeneTreeiENSGT00390000001502
HOGENOMiHOG000246959
HOVERGENiHBG080891
InParanoidiQ30KQ4
OMAiWNPCQLY
OrthoDBiEOG091G0XJT
PhylomeDBiQ30KQ4

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMKPCLMT IAILMILAQK TPGGLFRSHN GKSREPWNPC ELYQGMCRNA
60 70 80 90 100
CREYEIQYLT CPNDQKCCLK LSVKITSSKN VKEDYDSNSN LSVTNSSSYS

HI
Length:102
Mass (Da):11,544
Last modified:December 6, 2005 - v1
Checksum:iB8A488577CDA6925
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04886319Q → L. Corresponds to variant dbSNP:rs6119768Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012020 mRNA Translation: AAY59756.1
AL031650 Genomic DNA No translation available.
CCDSiCCDS42860.1
RefSeqiNP_001032820.1, NM_001037731.1
UniGeneiHs.580703

Genome annotation databases

EnsembliENST00000400549; ENSP00000383396; ENSG00000215545
GeneIDi245930
KEGGihsa:245930
UCSCiuc010ztm.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDB116_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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