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Protein

Beta-defensin 116

Gene

DEFB116

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 116
Alternative name(s):
Beta-defensin 16
Short name:
DEFB-16
Defensin, beta 116
Gene namesi
Name:DEFB116
Synonyms:DEFB16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:18097. DEFB116.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38493.

Polymorphism and mutation databases

BioMutaiDEFB116.
DMDMi84028878.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 10279Beta-defensin 116PRO_0000045344Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi40 ↔ 67By similarity
Disulfide bondi47 ↔ 61By similarity
Disulfide bondi51 ↔ 68By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ4.
PRIDEiQ30KQ4.

Expressioni

Gene expression databases

CleanExiHS_DEFB116.

Organism-specific databases

HPAiHPA047430.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4RG. Eukaryota.
ENOG41119R3. LUCA.
GeneTreeiENSGT00390000001502.
HOGENOMiHOG000246959.
HOVERGENiHBG080891.
InParanoidiQ30KQ4.
OMAiWNPCQLY.
OrthoDBiEOG7XDBJ5.
PhylomeDBiQ30KQ4.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMKPCLMT IAILMILAQK TPGGLFRSHN GKSREPWNPC ELYQGMCRNA
60 70 80 90 100
CREYEIQYLT CPNDQKCCLK LSVKITSSKN VKEDYDSNSN LSVTNSSSYS

HI
Length:102
Mass (Da):11,544
Last modified:December 6, 2005 - v1
Checksum:iB8A488577CDA6925
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191Q → L.
Corresponds to variant rs6119768 [ dbSNP | Ensembl ].
VAR_048863

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012020 mRNA. Translation: AAY59756.1.
AL031650 Genomic DNA. No translation available.
CCDSiCCDS42860.1.
RefSeqiNP_001032820.1. NM_001037731.1.
UniGeneiHs.580703.

Genome annotation databases

EnsembliENST00000400549; ENSP00000383396; ENSG00000215545.
GeneIDi245930.
KEGGihsa:245930.
UCSCiuc010ztm.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012020 mRNA. Translation: AAY59756.1.
AL031650 Genomic DNA. No translation available.
CCDSiCCDS42860.1.
RefSeqiNP_001032820.1. NM_001037731.1.
UniGeneiHs.580703.

3D structure databases

ProteinModelPortaliQ30KQ4.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiDEFB116.
DMDMi84028878.

Proteomic databases

PaxDbiQ30KQ4.
PRIDEiQ30KQ4.

Protocols and materials databases

DNASUi245930.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400549; ENSP00000383396; ENSG00000215545.
GeneIDi245930.
KEGGihsa:245930.
UCSCiuc010ztm.2. human.

Organism-specific databases

CTDi245930.
GeneCardsiDEFB116.
HGNCiHGNC:18097. DEFB116.
HPAiHPA047430.
neXtProtiNX_Q30KQ4.
PharmGKBiPA38493.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J4RG. Eukaryota.
ENOG41119R3. LUCA.
GeneTreeiENSGT00390000001502.
HOGENOMiHOG000246959.
HOVERGENiHBG080891.
InParanoidiQ30KQ4.
OMAiWNPCQLY.
OrthoDBiEOG7XDBJ5.
PhylomeDBiQ30KQ4.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii245930.
NextBioi91787.
PROiQ30KQ4.

Gene expression databases

CleanExiHS_DEFB116.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProDomiPD866254. PD866254. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDB116_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: May 11, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.