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Protein

Beta-defensin 130

Gene

DEFB130

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 130
Alternative name(s):
Beta-defensin 30
Short name:
DEFB-30
Defensin, beta 130
Gene namesi
Name:DEFB130
Synonyms:DEFB30
AND
Name:DEFB130L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:18107. DEFB130.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38503.

Polymorphism and mutation databases

BioMutaiDEFB130.
DMDMi84028890.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000004536923 – 79Beta-defensin 130Add BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi38 ↔ 53By similarity
Disulfide bondi43 ↔ 60By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KQ2.
PRIDEiQ30KQ2.

Expressioni

Gene expression databases

CleanExiHS_DEFB130.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000392568.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ2.
SMRiQ30KQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1NS. Eukaryota.
ENOG4111C32. LUCA.
GeneTreeiENSGT00840000130024.
HOGENOMiHOG000112161.
HOVERGENiHBG081406.
InParanoidiQ30KQ2.
OMAiDDTIGVC.
OrthoDBiEOG091G13U8.
PhylomeDBiQ30KQ2.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLHSLISVL LLFVTLIPKG KTGVIPGQKQ CIALKGVCRD KLCSTLDDTI
60 70
GICNEGKKCC RRWWILEPYP TPVPKGKSP
Length:79
Mass (Da):8,736
Last modified:December 6, 2005 - v1
Checksum:i65DF21FA1C40D507
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012022 mRNA. Translation: AAY59758.1.
AC232308 Genomic DNA. No translation available.
AC130366 Genomic DNA. No translation available.
CCDSiCCDS43714.1.
RefSeqiNP_001032893.1. NM_001037804.1.
NP_001182186.1. NM_001195257.1.
UniGeneiHs.581979.

Genome annotation databases

EnsembliENST00000400079; ENSP00000382951; ENSG00000232948.
GeneIDi100133267.
245940.
KEGGihsa:100133267.
hsa:245940.
UCSCiuc003wuz.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012022 mRNA. Translation: AAY59758.1.
AC232308 Genomic DNA. No translation available.
AC130366 Genomic DNA. No translation available.
CCDSiCCDS43714.1.
RefSeqiNP_001032893.1. NM_001037804.1.
NP_001182186.1. NM_001195257.1.
UniGeneiHs.581979.

3D structure databases

ProteinModelPortaliQ30KQ2.
SMRiQ30KQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000392568.

Polymorphism and mutation databases

BioMutaiDEFB130.
DMDMi84028890.

Proteomic databases

PaxDbiQ30KQ2.
PRIDEiQ30KQ2.

Protocols and materials databases

DNASUi245940.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400079; ENSP00000382951; ENSG00000232948.
GeneIDi100133267.
245940.
KEGGihsa:100133267.
hsa:245940.
UCSCiuc003wuz.1. human.

Organism-specific databases

CTDi245940.
GeneCardsiDEFB130.
HGNCiHGNC:18107. DEFB130.
neXtProtiNX_Q30KQ2.
PharmGKBiPA38503.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1NS. Eukaryota.
ENOG4111C32. LUCA.
GeneTreeiENSGT00840000130024.
HOGENOMiHOG000112161.
HOVERGENiHBG081406.
InParanoidiQ30KQ2.
OMAiDDTIGVC.
OrthoDBiEOG091G13U8.
PhylomeDBiQ30KQ2.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

PROiPR:Q30KQ2.

Gene expression databases

CleanExiHS_DEFB130.

Family and domain databases

InterProiView protein in InterPro
IPR001855. Defensin_beta-typ.
PfamiView protein in Pfam
PF00711. Defensin_beta. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDB130_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: March 15, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.