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Q30KQ1

- DB133_HUMAN

UniProt

Q30KQ1 - DB133_HUMAN

Protein

Beta-defensin 133

Gene

DEFB133

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 133
    Alternative name(s):
    Defensin, beta 133
    Gene namesi
    Name:DEFB133
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:31331. DEFB133.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134862169.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 6138Beta-defensin 133PRO_0000045358Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi31 ↔ 59By similarity
    Disulfide bondi38 ↔ 52By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ30KQ1.

    Expressioni

    Gene expression databases

    CleanExiHS_DEFB133.
    GenevestigatoriQ30KQ1.

    Organism-specific databases

    HPAiHPA044172.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381706.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG324905.
    HOGENOMiHOG000112163.
    HOVERGENiHBG084155.
    InParanoidiQ30KQ1.
    OMAiTYSCFIM.
    OrthoDBiEOG7PGDTW.
    PhylomeDBiQ30KQ1.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KQ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIHVFLFVL FFFLVPIATR VKCAVKDTYS CFIMRGKCRH ECHDFEKPIG   50
    FCTKLNANCY M 61
    Length:61
    Mass (Da):7,213
    Last modified:December 6, 2005 - v1
    Checksum:i71C7575DECC65BFE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012023 mRNA. Translation: AAY59759.1.
    AY621330 mRNA. Translation: AAT51869.1.
    RefSeqiNP_001159950.1. NM_001166478.1.
    UniGeneiHs.558270.
    Hs.745543.

    Genome annotation databases

    EnsembliENST00000398721; ENSP00000381706; ENSG00000214643.
    GeneIDi403339.
    KEGGihsa:403339.
    UCSCiuc003ozy.2. human.

    Polymorphism databases

    DMDMi84028894.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012023 mRNA. Translation: AAY59759.1 .
    AY621330 mRNA. Translation: AAT51869.1 .
    RefSeqi NP_001159950.1. NM_001166478.1.
    UniGenei Hs.558270.
    Hs.745543.

    3D structure databases

    ProteinModelPortali Q30KQ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381706.

    Polymorphism databases

    DMDMi 84028894.

    Proteomic databases

    PRIDEi Q30KQ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398721 ; ENSP00000381706 ; ENSG00000214643 .
    GeneIDi 403339.
    KEGGi hsa:403339.
    UCSCi uc003ozy.2. human.

    Organism-specific databases

    CTDi 403339.
    GeneCardsi GC06M049914.
    HGNCi HGNC:31331. DEFB133.
    HPAi HPA044172.
    neXtProti NX_Q30KQ1.
    PharmGKBi PA134862169.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324905.
    HOGENOMi HOG000112163.
    HOVERGENi HBG084155.
    InParanoidi Q30KQ1.
    OMAi TYSCFIM.
    OrthoDBi EOG7PGDTW.
    PhylomeDBi Q30KQ1.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 107778.
    PROi Q30KQ1.

    Gene expression databases

    CleanExi HS_DEFB133.
    Genevestigatori Q30KQ1.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
      Patil A., Zhang G.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-61.

    Entry informationi

    Entry nameiDB133_HUMAN
    AccessioniPrimary (citable) accession number: Q30KQ1
    Secondary accession number(s): Q4QY39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was termed () DEFB134.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3