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Q30KQ1 (DB133_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 133
Alternative name(s):
Defensin, beta 133
Gene names
Name:DEFB133
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length61 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the beta-defensin family.

Caution

Was termed (Ref.2) DEFB134.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 6138Beta-defensin 133
PRO_0000045358

Amino acid modifications

Disulfide bond31 ↔ 59 By similarity
Disulfide bond38 ↔ 52 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30KQ1 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 71C7575DECC65BFE

FASTA617,213
        10         20         30         40         50         60 
MKIHVFLFVL FFFLVPIATR VKCAVKDTYS CFIMRGKCRH ECHDFEKPIG FCTKLNANCY 


M 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
Patil A., Zhang G.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-61.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012023 mRNA. Translation: AAY59759.1.
AY621330 mRNA. Translation: AAT51869.1.
RefSeqNP_001159950.1. NM_001166478.1.
UniGeneHs.558270.
Hs.745543.

3D structure databases

ProteinModelPortalQ30KQ1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000381706.

Polymorphism databases

DMDM84028894.

Proteomic databases

PRIDEQ30KQ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000398721; ENSP00000381706; ENSG00000214643.
GeneID403339.
KEGGhsa:403339.
UCSCuc003ozy.2. human.

Organism-specific databases

CTD403339.
GeneCardsGC06M049914.
HGNCHGNC:31331. DEFB133.
HPAHPA044172.
neXtProtNX_Q30KQ1.
PharmGKBPA134862169.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG324905.
HOGENOMHOG000112163.
HOVERGENHBG084155.
InParanoidQ30KQ1.
OMATYSCFIM.
OrthoDBEOG7PGDTW.
PhylomeDBQ30KQ1.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_DEFB133.
GenevestigatorQ30KQ1.

Family and domain databases

InterProIPR025933. Beta_defensin.
[Graphical view]
PfamPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio107778.
PROQ30KQ1.

Entry information

Entry nameDB133_HUMAN
AccessionPrimary (citable) accession number: Q30KQ1
Secondary accession number(s): Q4QY39
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM