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Q30KQ1

- DB133_HUMAN

UniProt

Q30KQ1 - DB133_HUMAN

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Protein
Beta-defensin 133
Gene
DEFB133
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Has antibacterial activity Reviewed prediction.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 133
Alternative name(s):
Defensin, beta 133
Gene namesi
Name:DEFB133
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:31331. DEFB133.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134862169.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 6138Beta-defensin 133
PRO_0000045358Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 59 By similarity
Disulfide bondi38 ↔ 52 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KQ1.

Expressioni

Gene expression databases

CleanExiHS_DEFB133.
GenevestigatoriQ30KQ1.

Organism-specific databases

HPAiHPA044172.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381706.

Structurei

3D structure databases

ProteinModelPortaliQ30KQ1.

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG324905.
HOGENOMiHOG000112163.
HOVERGENiHBG084155.
InParanoidiQ30KQ1.
OMAiTYSCFIM.
OrthoDBiEOG7PGDTW.
PhylomeDBiQ30KQ1.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KQ1-1 [UniParc]FASTAAdd to Basket

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MKIHVFLFVL FFFLVPIATR VKCAVKDTYS CFIMRGKCRH ECHDFEKPIG   50
FCTKLNANCY M 61
Length:61
Mass (Da):7,213
Last modified:December 6, 2005 - v1
Checksum:i71C7575DECC65BFE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012023 mRNA. Translation: AAY59759.1.
AY621330 mRNA. Translation: AAT51869.1.
RefSeqiNP_001159950.1. NM_001166478.1.
UniGeneiHs.558270.
Hs.745543.

Genome annotation databases

EnsembliENST00000398721; ENSP00000381706; ENSG00000214643.
GeneIDi403339.
KEGGihsa:403339.
UCSCiuc003ozy.2. human.

Polymorphism databases

DMDMi84028894.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012023 mRNA. Translation: AAY59759.1 .
AY621330 mRNA. Translation: AAT51869.1 .
RefSeqi NP_001159950.1. NM_001166478.1.
UniGenei Hs.558270.
Hs.745543.

3D structure databases

ProteinModelPortali Q30KQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381706.

Polymorphism databases

DMDMi 84028894.

Proteomic databases

PRIDEi Q30KQ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000398721 ; ENSP00000381706 ; ENSG00000214643 .
GeneIDi 403339.
KEGGi hsa:403339.
UCSCi uc003ozy.2. human.

Organism-specific databases

CTDi 403339.
GeneCardsi GC06M049914.
HGNCi HGNC:31331. DEFB133.
HPAi HPA044172.
neXtProti NX_Q30KQ1.
PharmGKBi PA134862169.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324905.
HOGENOMi HOG000112163.
HOVERGENi HBG084155.
InParanoidi Q30KQ1.
OMAi TYSCFIM.
OrthoDBi EOG7PGDTW.
PhylomeDBi Q30KQ1.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

NextBioi 107778.
PROi Q30KQ1.

Gene expression databases

CleanExi HS_DEFB133.
Genevestigatori Q30KQ1.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-61.

Entry informationi

Entry nameiDB133_HUMAN
AccessioniPrimary (citable) accession number: Q30KQ1
Secondary accession number(s): Q4QY39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed () DEFB134.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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