Q30KQ1 (DB133_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 133

Alternative name(s):
Defensin, beta 133

Gene names

Name:

DEFB133

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	61 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the beta-defensin family.
Caution	Was termed (Ref.2) DEFB134.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 61	38	Beta-defensin 133		PRO_0000045358
Amino acid modifications
	Disulfide bond	31 ↔ 59		By similarity
	Disulfide bond	38 ↔ 52		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30KQ1 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 71C7575DECC65BFE	FASTA	61	7,213
	10 20 30 40 50 60 MKIHVFLFVL FFFLVPIATR VKCAVKDTYS CFIMRGKCRH ECHDFEKPIG FCTKLNANCY M

References

[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals." Patil A., Zhang G. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-61.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012023 mRNA. Translation: AAY59759.1. AY621330 mRNA. Translation: AAT51869.1.
IPI	IPI00746490.
RefSeq	NP_001159950.1. NM_001166478.1.
UniGene	Hs.558270. Hs.741093.
3D structure databases
ProteinModelPortal	Q30KQ1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000381706.
Polymorphism databases
DMDM	84028894.
Proteomic databases
PRIDE	Q30KQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000398721; ENSP00000381706; ENSG00000214643.
GeneID	403339.
KEGG	hsa:403339.
UCSC	uc003ozy.2. human.
Organism-specific databases
CTD	403339.
GeneCards	GC06M049914.
HGNC	HGNC:31331. DEFB133.
HPA	HPA044172.
neXtProt	NX_Q30KQ1.
PharmGKB	PA134862169.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG324905.
HOGENOM	HOG000112163.
HOVERGEN	HBG084155.
InParanoid	Q30KQ1.
OMA	KCRHECH.
OrthoDB	EOG4WWRM8.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
CleanEx	HS_DEFB133.
Genevestigator	Q30KQ1.
Family and domain databases
InterPro	IPR025933. Beta_defensin. [Graphical view]
Pfam	PF13841. Defensin_beta_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	107778.

Entry information

Entry name

DB133_HUMAN

Accession

Primary (citable) accession number: Q30KQ1
Secondary accession number(s): Q4QY39

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.