ID   DB135_HUMAN             Reviewed;          77 AA.
AC   Q30KP9; Q4QY37;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Beta-defensin 135;
DE   AltName: Full=Defensin, beta 135;
DE   Flags: Precursor;
GN   Name=DEFB135;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-66.
RA   Patil A., Zhang G.;
RT   "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT   four syntenic defensin gene clusters in mammals.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Was termed (Ref.2) DEFB136. {ECO:0000305}.
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DR   EMBL; DQ012025; AAY59761.1; -; mRNA.
DR   EMBL; AY621332; AAT51871.1; -; mRNA.
DR   CCDS; CCDS43710.1; -.
DR   RefSeq; NP_001028189.2; NM_001033017.2.
DR   RefSeq; XP_016885979.1; XM_017030490.1.
DR   AlphaFoldDB; Q30KP9; -.
DR   SMR; Q30KP9; -.
DR   BioGRID; 534789; 235.
DR   STRING; 9606.ENSP00000371643; -.
DR   BioMuta; DEFB135; -.
DR   DMDM; 84028897; -.
DR   PaxDb; 9606-ENSP00000371643; -.
DR   Antibodypedia; 50843; 14 antibodies from 1 providers.
DR   DNASU; 613209; -.
DR   Ensembl; ENST00000382208.3; ENSP00000371643.2; ENSG00000205883.3.
DR   Ensembl; ENST00000645596.2; ENSP00000495605.1; ENSG00000285365.2.
DR   GeneID; 613209; -.
DR   KEGG; hsa:613209; -.
DR   MANE-Select; ENST00000382208.3; ENSP00000371643.2; NM_001033017.3; NP_001028189.2.
DR   UCSC; uc003wuw.1; human.
DR   AGR; HGNC:32400; -.
DR   CTD; 613209; -.
DR   GeneCards; DEFB135; -.
DR   HGNC; HGNC:32400; DEFB135.
DR   HPA; ENSG00000205883; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KP9; -.
DR   PharmGKB; PA165585476; -.
DR   VEuPathDB; HostDB:ENSG00000205883; -.
DR   eggNOG; ENOG502TF02; Eukaryota.
DR   GeneTree; ENSGT00530000064429; -.
DR   HOGENOM; CLU_181906_3_0_1; -.
DR   InParanoid; Q30KP9; -.
DR   OMA; NTCWRTK; -.
DR   OrthoDB; 5003090at2759; -.
DR   PhylomeDB; Q30KP9; -.
DR   PathwayCommons; Q30KP9; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   BioGRID-ORCS; 613209; 13 hits in 1138 CRISPR screens.
DR   Pharos; Q30KP9; Tdark.
DR   PRO; PR:Q30KP9; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q30KP9; Protein.
DR   Bgee; ENSG00000205883; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 68 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:InterPro.
DR   InterPro; IPR025933; Beta_defensin.
DR   PANTHER; PTHR15001; BETA-DEFENSIN 123-RELATED; 1.
DR   PANTHER; PTHR15001:SF10; BETA-DEFENSIN 135; 1.
DR   Pfam; PF13841; Defensin_beta_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..77
FT                   /note="Beta-defensin 135"
FT                   /id="PRO_0000045362"
FT   DISULFID        37..64
FT                   /evidence="ECO:0000250"
FT   DISULFID        44..58
FT                   /evidence="ECO:0000250"
FT   DISULFID        48..65
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   77 AA;  8754 MW;  010E3EF6D54984F2 CRC64;
     MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK NEQYRILCDT
     IHLCCVNPKY LPILTGK
//