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Q30KP9

- DB135_HUMAN

UniProt

Q30KP9 - DB135_HUMAN

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Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 135
Alternative name(s):
Defensin, beta 135
Gene namesi
Name:DEFB135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:32400. DEFB135.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 7753Beta-defensin 135PRO_0000045362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 64By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi48 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Expressioni

Gene expression databases

GenevestigatoriQ30KP9.

Organism-specific databases

HPAiHPA044176.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Structurei

3D structure databases

ProteinModelPortaliQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG121792.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiIFASCWR.
OrthoDBiEOG7KWSMC.
PhylomeDBiQ30KP9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK
60 70
NEQYRILCDT IHLCCVNPKY LPILTGK
Length:77
Mass (Da):8,754
Last modified:December 6, 2005 - v1
Checksum:i010E3EF6D54984F2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
UniGeneiHs.558284.

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi613209.
KEGGihsa:613209.
UCSCiuc003wuw.1. human.

Polymorphism databases

DMDMi84028897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012025 mRNA. Translation: AAY59761.1 .
AY621332 mRNA. Translation: AAT51871.1 .
CCDSi CCDS43710.1.
RefSeqi NP_001028189.2. NM_001033017.2.
UniGenei Hs.558284.

3D structure databases

ProteinModelPortali Q30KP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371643.

Polymorphism databases

DMDMi 84028897.

Proteomic databases

PaxDbi Q30KP9.
PRIDEi Q30KP9.

Protocols and materials databases

DNASUi 613209.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382208 ; ENSP00000371643 ; ENSG00000205883 .
GeneIDi 613209.
KEGGi hsa:613209.
UCSCi uc003wuw.1. human.

Organism-specific databases

CTDi 613209.
GeneCardsi GC08P011839.
HGNCi HGNC:32400. DEFB135.
HPAi HPA044176.
neXtProti NX_Q30KP9.
PharmGKBi PA165585476.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG121792.
GeneTreei ENSGT00530000064429.
HOGENOMi HOG000246960.
HOVERGENi HBG095988.
InParanoidi Q30KP9.
OMAi IFASCWR.
OrthoDBi EOG7KWSMC.
PhylomeDBi Q30KP9.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 613209.
NextBioi 112838.
PROi Q30KP9.

Gene expression databases

Genevestigatori Q30KP9.

Family and domain databases

InterProi IPR025933. Beta_defensin.
[Graphical view ]
Pfami PF13841. Defensin_beta_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-66.

Entry informationi

Entry nameiDB135_HUMAN
AccessioniPrimary (citable) accession number: Q30KP9
Secondary accession number(s): Q4QY37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed () DEFB136.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3