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Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 135
Alternative name(s):
Defensin, beta 135
Gene namesi
Name:DEFB135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000205883.2.
HGNCiHGNC:32400. DEFB135.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585476.

Polymorphism and mutation databases

BioMutaiDEFB135.
DMDMi84028897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004536225 – 77Beta-defensin 135Add BLAST53

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 64By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi48 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Expressioni

Gene expression databases

BgeeiENSG00000205883.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Structurei

3D structure databases

ProteinModelPortaliQ30KP9.
SMRiQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J49I. Eukaryota.
ENOG4111DTG. LUCA.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiRSGPNVY.
OrthoDBiEOG091G1991.
PhylomeDBiQ30KP9.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254. PD866254. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK
60 70
NEQYRILCDT IHLCCVNPKY LPILTGK
Length:77
Mass (Da):8,754
Last modified:December 6, 2005 - v1
Checksum:i010E3EF6D54984F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
XP_016885979.1. XM_017030490.1.
UniGeneiHs.558284.

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi107987561.
613209.
KEGGihsa:107987561.
hsa:613209.
UCSCiuc003wuw.1. human.

Similar proteinsi

Entry informationi

Entry nameiDB135_HUMAN
AccessioniPrimary (citable) accession number: Q30KP9
Secondary accession number(s): Q4QY37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: September 27, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 2) DEFB136.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families