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Q30KP9

- DB135_HUMAN

UniProt

Q30KP9 - DB135_HUMAN

Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 135
    Alternative name(s):
    Defensin, beta 135
    Gene namesi
    Name:DEFB135
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:32400. DEFB135.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165585476.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 7753Beta-defensin 135PRO_0000045362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 64By similarity
    Disulfide bondi44 ↔ 58By similarity
    Disulfide bondi48 ↔ 65By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ30KP9.
    PRIDEiQ30KP9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ30KP9.

    Organism-specific databases

    HPAiHPA044176.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG121792.
    HOGENOMiHOG000246960.
    HOVERGENiHBG095988.
    InParanoidiQ30KP9.
    OMAiIFASCWR.
    OrthoDBiEOG7KWSMC.
    PhylomeDBiQ30KP9.

    Family and domain databases

    InterProiIPR025933. Beta_defensin.
    [Graphical view]
    PfamiPF13841. Defensin_beta_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK   50
    NEQYRILCDT IHLCCVNPKY LPILTGK 77
    Length:77
    Mass (Da):8,754
    Last modified:December 6, 2005 - v1
    Checksum:i010E3EF6D54984F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012025 mRNA. Translation: AAY59761.1.
    AY621332 mRNA. Translation: AAT51871.1.
    CCDSiCCDS43710.1.
    RefSeqiNP_001028189.2. NM_001033017.2.
    UniGeneiHs.558284.

    Genome annotation databases

    EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
    GeneIDi613209.
    KEGGihsa:613209.
    UCSCiuc003wuw.1. human.

    Polymorphism databases

    DMDMi84028897.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012025 mRNA. Translation: AAY59761.1 .
    AY621332 mRNA. Translation: AAT51871.1 .
    CCDSi CCDS43710.1.
    RefSeqi NP_001028189.2. NM_001033017.2.
    UniGenei Hs.558284.

    3D structure databases

    ProteinModelPortali Q30KP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371643.

    Polymorphism databases

    DMDMi 84028897.

    Proteomic databases

    PaxDbi Q30KP9.
    PRIDEi Q30KP9.

    Protocols and materials databases

    DNASUi 613209.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382208 ; ENSP00000371643 ; ENSG00000205883 .
    GeneIDi 613209.
    KEGGi hsa:613209.
    UCSCi uc003wuw.1. human.

    Organism-specific databases

    CTDi 613209.
    GeneCardsi GC08P011839.
    HGNCi HGNC:32400. DEFB135.
    HPAi HPA044176.
    neXtProti NX_Q30KP9.
    PharmGKBi PA165585476.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG121792.
    HOGENOMi HOG000246960.
    HOVERGENi HBG095988.
    InParanoidi Q30KP9.
    OMAi IFASCWR.
    OrthoDBi EOG7KWSMC.
    PhylomeDBi Q30KP9.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 112838.
    PROi Q30KP9.

    Gene expression databases

    Genevestigatori Q30KP9.

    Family and domain databases

    InterProi IPR025933. Beta_defensin.
    [Graphical view ]
    Pfami PF13841. Defensin_beta_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
      Patil A., Zhang G.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-66.

    Entry informationi

    Entry nameiDB135_HUMAN
    AccessioniPrimary (citable) accession number: Q30KP9
    Secondary accession number(s): Q4QY37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was termed () DEFB136.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3