Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: GO_Central
  2. innate immune response Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 135
Alternative name(s):
Defensin, beta 135
Gene namesi
Name:DEFB135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32400. DEFB135.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. cell surface Source: GO_Central
  2. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585476.

Polymorphism and mutation databases

BioMutaiDEFB135.
DMDMi84028897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 7753Beta-defensin 135PRO_0000045362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 64By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi48 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Expressioni

Gene expression databases

GenevestigatoriQ30KP9.

Organism-specific databases

HPAiHPA044176.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Structurei

3D structure databases

ProteinModelPortaliQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG121792.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiRSGPNVY.
OrthoDBiEOG7KWSMC.
PhylomeDBiQ30KP9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK
60 70
NEQYRILCDT IHLCCVNPKY LPILTGK
Length:77
Mass (Da):8,754
Last modified:December 6, 2005 - v1
Checksum:i010E3EF6D54984F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
UniGeneiHs.558284.

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi613209.
KEGGihsa:613209.
UCSCiuc003wuw.1. human.

Polymorphism and mutation databases

BioMutaiDEFB135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
UniGeneiHs.558284.

3D structure databases

ProteinModelPortaliQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Polymorphism and mutation databases

BioMutaiDEFB135.
DMDMi84028897.

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Protocols and materials databases

DNASUi613209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi613209.
KEGGihsa:613209.
UCSCiuc003wuw.1. human.

Organism-specific databases

CTDi613209.
GeneCardsiGC08P011839.
HGNCiHGNC:32400. DEFB135.
HPAiHPA044176.
neXtProtiNX_Q30KP9.
PharmGKBiPA165585476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG121792.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiRSGPNVY.
OrthoDBiEOG7KWSMC.
PhylomeDBiQ30KP9.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii613209.
NextBioi112838.
PROiQ30KP9.

Gene expression databases

GenevestigatoriQ30KP9.

Family and domain databases

InterProiIPR025933. Beta_defensin.
[Graphical view]
PfamiPF13841. Defensin_beta_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-66.

Entry informationi

Entry nameiDB135_HUMAN
AccessioniPrimary (citable) accession number: Q30KP9
Secondary accession number(s): Q4QY37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: April 29, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 2) DEFB136.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.