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Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

Caution

Was termed (Ref. 2) DEFB136.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-1461973 Defensins

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 135
Alternative name(s):
Defensin, beta 135
Gene namesi
Name:DEFB135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000205883.2
HGNCiHGNC:32400 DEFB135
neXtProtiNX_Q30KP9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585476

Polymorphism and mutation databases

BioMutaiDEFB135
DMDMi84028897

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004536225 – 77Beta-defensin 135Add BLAST53

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 64By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi48 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP9
PRIDEiQ30KP9

Expressioni

Gene expression databases

BgeeiENSG00000205883

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371643

Structurei

3D structure databases

ProteinModelPortaliQ30KP9
SMRiQ30KP9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J49I Eukaryota
ENOG4111DTG LUCA
GeneTreeiENSGT00530000064429
HOGENOMiHOG000246960
HOVERGENiHBG095988
InParanoidiQ30KP9
OMAiRSGPNVY
OrthoDBiEOG091G1991
PhylomeDBiQ30KP9

Family and domain databases

InterProiView protein in InterPro
IPR025933 Beta_defensin
PANTHERiPTHR15001 PTHR15001, 1 hit
PfamiView protein in Pfam
PF13841 Defensin_beta_2, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254 PD866254, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK
60 70
NEQYRILCDT IHLCCVNPKY LPILTGK
Length:77
Mass (Da):8,754
Last modified:December 6, 2005 - v1
Checksum:i010E3EF6D54984F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA Translation: AAY59761.1
AY621332 mRNA Translation: AAT51871.1
CCDSiCCDS43710.1
RefSeqiNP_001028189.2, NM_001033017.2
XP_016885979.1, XM_017030490.1
UniGeneiHs.558284

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883
GeneIDi613209
KEGGihsa:107987561
hsa:613209
UCSCiuc003wuw.1 human

Similar proteinsi

Entry informationi

Entry nameiDB135_HUMAN
AccessioniPrimary (citable) accession number: Q30KP9
Secondary accession number(s): Q4QY37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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