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Protein

Beta-defensin 135

Gene

DEFB135

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 135
Alternative name(s):
Defensin, beta 135
Gene namesi
Name:DEFB135
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32400. DEFB135.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585476.

Polymorphism and mutation databases

BioMutaiDEFB135.
DMDMi84028897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000004536225 – 77Beta-defensin 135Add BLAST53

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 64By similarity
Disulfide bondi44 ↔ 58By similarity
Disulfide bondi48 ↔ 65By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Structurei

3D structure databases

ProteinModelPortaliQ30KP9.
SMRiQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J49I. Eukaryota.
ENOG4111DTG. LUCA.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiRSGPNVY.
OrthoDBiEOG091G1991.
PhylomeDBiQ30KP9.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254. PD866254. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRSVLLAL VVLNLLFYVP PGRSGPNVYI QKIFASCWRL QGTCRPKCLK
60 70
NEQYRILCDT IHLCCVNPKY LPILTGK
Length:77
Mass (Da):8,754
Last modified:December 6, 2005 - v1
Checksum:i010E3EF6D54984F2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
XP_016885979.1. XM_017030490.1.
UniGeneiHs.558284.

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi107987561.
613209.
KEGGihsa:107987561.
hsa:613209.
UCSCiuc003wuw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012025 mRNA. Translation: AAY59761.1.
AY621332 mRNA. Translation: AAT51871.1.
CCDSiCCDS43710.1.
RefSeqiNP_001028189.2. NM_001033017.2.
XP_016885979.1. XM_017030490.1.
UniGeneiHs.558284.

3D structure databases

ProteinModelPortaliQ30KP9.
SMRiQ30KP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371643.

Polymorphism and mutation databases

BioMutaiDEFB135.
DMDMi84028897.

Proteomic databases

PaxDbiQ30KP9.
PRIDEiQ30KP9.

Protocols and materials databases

DNASUi613209.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382208; ENSP00000371643; ENSG00000205883.
GeneIDi107987561.
613209.
KEGGihsa:107987561.
hsa:613209.
UCSCiuc003wuw.1. human.

Organism-specific databases

CTDi613209.
GeneCardsiDEFB135.
HGNCiHGNC:32400. DEFB135.
neXtProtiNX_Q30KP9.
PharmGKBiPA165585476.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J49I. Eukaryota.
ENOG4111DTG. LUCA.
GeneTreeiENSGT00530000064429.
HOGENOMiHOG000246960.
HOVERGENiHBG095988.
InParanoidiQ30KP9.
OMAiRSGPNVY.
OrthoDBiEOG091G1991.
PhylomeDBiQ30KP9.

Enzyme and pathway databases

ReactomeiR-HSA-1461957. Beta defensins.
R-HSA-1461973. Defensins.

Miscellaneous databases

GenomeRNAii613209.
PROiQ30KP9.

Family and domain databases

InterProiView protein in InterPro
IPR025933. Beta_defensin.
PANTHERiPTHR15001. PTHR15001. 1 hit.
PfamiView protein in Pfam
PF13841. Defensin_beta_2. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD866254. PD866254. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDB135_HUMAN
AccessioniPrimary (citable) accession number: Q30KP9
Secondary accession number(s): Q4QY37
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: March 15, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed (Ref. 2) DEFB136.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.