ID   DB136_HUMAN             Reviewed;          78 AA.
AC   Q30KP8; Q4QY36;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   24-JAN-2024, entry version 111.
DE   RecName: Full=Defensin beta 136 {ECO:0000312|HGNC:HGNC:34433};
DE   AltName: Full=Beta-defensin 136 {ECO:0000303|PubMed:16033865};
DE   AltName: Full=DEFB137 {ECO:0000303|Ref.2};
DE   Flags: Precursor;
GN   Name=DEFB136;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16033865; DOI=10.1152/physiolgenomics.00104.2005;
RA   Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.;
RT   "Cross-species analysis of the mammalian beta-defensin gene family:
RT   presence of syntenic gene clusters and preferential expression in the male
RT   reproductive tract.";
RL   Physiol. Genomics 23:5-17(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.
RA   Patil A., Zhang G.;
RT   "Genome-wide analysis of rat beta-defensins: evidence for the existence of
RT   four syntenic defensin gene clusters in mammals.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   FUNCTION.
RX   PubMed=34481960; DOI=10.1016/j.pep.2021.105968;
RA   Liu H., Diao H., Hou J., Yu H., Wen H.;
RT   "Soluble expression and purification of human beta-defensin DEFB136 in
RT   Escherichia coli and identification of its bioactivity.";
RL   Protein Expr. Purif. 188:105968-105968(2021).
CC   -!- FUNCTION: Host defense peptide that exhibits antibacterial and
CC       antifungal activity (PubMed:34481960). Exhibits antimicrobial activity
CC       against E.coli, S.aureus and C.albicans (in vitro) (PubMed:34481960).
CC       Has high lipopolysaccharide (LPS)-binding affinity, and may thereby be
CC       involved in immunoregulation through LPS neutralization
CC       (PubMed:34481960). {ECO:0000269|PubMed:34481960}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60022}.
CC   -!- SIMILARITY: Belongs to the beta-defensin family. {ECO:0000305}.
CC   -!- CAUTION: Was termed (Ref.2) DEFB137. {ECO:0000305}.
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DR   EMBL; DQ012026; AAY59762.1; -; mRNA.
DR   EMBL; AY621333; AAT51872.1; -; mRNA.
DR   CCDS; CCDS43709.1; -.
DR   RefSeq; NP_001028190.2; NM_001033018.2.
DR   RefSeq; XP_016885978.1; XM_017030489.1.
DR   AlphaFoldDB; Q30KP8; -.
DR   BioGRID; 534790; 79.
DR   STRING; 9606.ENSP00000371644; -.
DR   BioMuta; DEFB136; -.
DR   DMDM; 84028899; -.
DR   PaxDb; 9606-ENSP00000371644; -.
DR   PeptideAtlas; Q30KP8; -.
DR   Antibodypedia; 67428; 9 antibodies from 6 providers.
DR   DNASU; 613210; -.
DR   Ensembl; ENST00000382209.2; ENSP00000371644.2; ENSG00000205884.2.
DR   Ensembl; ENST00000646795.1; ENSP00000494776.1; ENSG00000285087.1.
DR   GeneID; 613210; -.
DR   KEGG; hsa:613210; -.
DR   MANE-Select; ENST00000382209.2; ENSP00000371644.2; NM_001033018.2; NP_001028190.2.
DR   UCSC; uc011kxm.2; human.
DR   AGR; HGNC:34433; -.
DR   CTD; 613210; -.
DR   GeneCards; DEFB136; -.
DR   HGNC; HGNC:34433; DEFB136.
DR   HPA; ENSG00000205884; Tissue enriched (epididymis).
DR   neXtProt; NX_Q30KP8; -.
DR   OpenTargets; ENSG00000205884; -.
DR   PharmGKB; PA165585543; -.
DR   VEuPathDB; HostDB:ENSG00000205884; -.
DR   eggNOG; ENOG502R7G8; Eukaryota.
DR   GeneTree; ENSGT00390000001862; -.
DR   HOGENOM; CLU_198474_0_0_1; -.
DR   InParanoid; Q30KP8; -.
DR   OMA; WVAFCHN; -.
DR   OrthoDB; 4718456at2759; -.
DR   PhylomeDB; Q30KP8; -.
DR   TreeFam; TF343350; -.
DR   PathwayCommons; Q30KP8; -.
DR   Reactome; R-HSA-1461957; Beta defensins.
DR   Reactome; R-HSA-1461973; Defensins.
DR   BioGRID-ORCS; 613210; 10 hits in 1104 CRISPR screens.
DR   Pharos; Q30KP8; Tdark.
DR   PRO; PR:Q30KP8; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q30KP8; Protein.
DR   Bgee; ENSG00000205884; Expressed in superior frontal gyrus and 63 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001530; F:lipopolysaccharide binding; IDA:UniProtKB.
DR   GO; GO:0140367; P:antibacterial innate immune response; IDA:UniProtKB.
DR   GO; GO:0061760; P:antifungal innate immune response; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR035307; DEFB136/42.
DR   PANTHER; PTHR39413; BETA-DEFENSIN 136; 1.
DR   PANTHER; PTHR39413:SF1; BETA-DEFENSIN 136; 1.
DR   Pfam; PF17333; DEFB136; 1.
DR   SUPFAM; SSF57392; Defensin-like; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Defensin; Disulfide bond; Fungicide;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..78
FT                   /note="Defensin beta 136"
FT                   /id="PRO_0000045364"
FT   DISULFID        33..60
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
FT   DISULFID        40..54
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
FT   DISULFID        44..61
FT                   /evidence="ECO:0000250|UniProtKB:P81534"
SQ   SEQUENCE   78 AA;  8755 MW;  26F291E8E0EF3A40 CRC64;
     MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC
     CKNMTRFQPP QAKDPWVH
//