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Q30KP8 (DB136_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-defensin 136
Alternative name(s):
Defensin, beta 136
Gene names
Name:DEFB136
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has antibacterial activity Potential.

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the beta-defensin family.

Caution

Was termed (Ref.2) DEFB137.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionAntibiotic
Antimicrobial
Defensin
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processdefense response to bacterium

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 7857Beta-defensin 136
PRO_0000045364

Amino acid modifications

Disulfide bond33 ↔ 60 By similarity
Disulfide bond40 ↔ 54 By similarity
Disulfide bond44 ↔ 61 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q30KP8 [UniParc].

Last modified December 6, 2005. Version 1.
Checksum: 26F291E8E0EF3A40

FASTA788,755
        10         20         30         40         50         60 
MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC 

        70 
CKNMTRFQPP QAKDPWVH 

« Hide

References

[1]"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
Patil A., Zhang G.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ012026 mRNA. Translation: AAY59762.1.
AY621333 mRNA. Translation: AAT51872.1.
RefSeqNP_001028190.2. NM_001033018.2.
UniGeneHs.558285.

3D structure databases

ProteinModelPortalQ30KP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000371644.

Polymorphism databases

DMDM84028899.

Proteomic databases

PRIDEQ30KP8.

Protocols and materials databases

DNASU613210.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000382209; ENSP00000371644; ENSG00000205884.
GeneID613210.
KEGGhsa:613210.
UCSCuc011kxm.2. human.

Organism-specific databases

CTD613210.
GeneCardsGC08M011831.
HGNCHGNC:34433. DEFB136.
neXtProtNX_Q30KP8.
PharmGKBPA165585543.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG140158.
HOGENOMHOG000112165.
HOVERGENHBG069057.
InParanoidQ30KP8.
OMAFCHNILS.
OrthoDBEOG7KH9NK.
PhylomeDBQ30KP8.
TreeFamTF343350.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorQ30KP8.

Family and domain databases

ProtoNetSearch...

Other

NextBio112841.
PROQ30KP8.

Entry information

Entry nameDB136_HUMAN
AccessionPrimary (citable) accession number: Q30KP8
Secondary accession number(s): Q4QY36
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM