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Q30KP8

- DB136_HUMAN

UniProt

Q30KP8 - DB136_HUMAN

Protein

Beta-defensin 136

Gene

DEFB136

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Has antibacterial activity.Curated

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Defensin

    Enzyme and pathway databases

    ReactomeiREACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-defensin 136
    Alternative name(s):
    Defensin, beta 136
    Gene namesi
    Name:DEFB136
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:34433. DEFB136.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165585543.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 7857Beta-defensin 136PRO_0000045364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi33 ↔ 60By similarity
    Disulfide bondi40 ↔ 54By similarity
    Disulfide bondi44 ↔ 61By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ30KP8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ30KP8.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000371644.

    Structurei

    3D structure databases

    ProteinModelPortaliQ30KP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-defensin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG140158.
    HOGENOMiHOG000112165.
    HOVERGENiHBG069057.
    InParanoidiQ30KP8.
    OMAiPPQAKDP.
    OrthoDBiEOG7KH9NK.
    PhylomeDBiQ30KP8.
    TreeFamiTF343350.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q30KP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW   50
    IAFCHNILSC CKNMTRFQPP QAKDPWVH 78
    Length:78
    Mass (Da):8,755
    Last modified:December 6, 2005 - v1
    Checksum:i26F291E8E0EF3A40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012026 mRNA. Translation: AAY59762.1.
    AY621333 mRNA. Translation: AAT51872.1.
    CCDSiCCDS43709.1.
    RefSeqiNP_001028190.2. NM_001033018.2.
    UniGeneiHs.558285.

    Genome annotation databases

    EnsembliENST00000382209; ENSP00000371644; ENSG00000205884.
    GeneIDi613210.
    KEGGihsa:613210.
    UCSCiuc011kxm.2. human.

    Polymorphism databases

    DMDMi84028899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ012026 mRNA. Translation: AAY59762.1 .
    AY621333 mRNA. Translation: AAT51872.1 .
    CCDSi CCDS43709.1.
    RefSeqi NP_001028190.2. NM_001033018.2.
    UniGenei Hs.558285.

    3D structure databases

    ProteinModelPortali Q30KP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000371644.

    Polymorphism databases

    DMDMi 84028899.

    Proteomic databases

    PRIDEi Q30KP8.

    Protocols and materials databases

    DNASUi 613210.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000382209 ; ENSP00000371644 ; ENSG00000205884 .
    GeneIDi 613210.
    KEGGi hsa:613210.
    UCSCi uc011kxm.2. human.

    Organism-specific databases

    CTDi 613210.
    GeneCardsi GC08M011831.
    HGNCi HGNC:34433. DEFB136.
    neXtProti NX_Q30KP8.
    PharmGKBi PA165585543.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG140158.
    HOGENOMi HOG000112165.
    HOVERGENi HBG069057.
    InParanoidi Q30KP8.
    OMAi PPQAKDP.
    OrthoDBi EOG7KH9NK.
    PhylomeDBi Q30KP8.
    TreeFami TF343350.

    Enzyme and pathway databases

    Reactomei REACT_115846. Defensins.
    REACT_115897. Beta defensins.

    Miscellaneous databases

    NextBioi 112841.
    PROi Q30KP8.

    Gene expression databases

    Genevestigatori Q30KP8.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
      Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
      Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
      Patil A., Zhang G.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.

    Entry informationi

    Entry nameiDB136_HUMAN
    AccessioniPrimary (citable) accession number: Q30KP8
    Secondary accession number(s): Q4QY36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was termed () DEFB137.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3