Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q30KP8

- DB136_HUMAN

UniProt

Q30KP8 - DB136_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Beta-defensin 136

Gene

DEFB136

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 136
Alternative name(s):
Defensin, beta 136
Gene namesi
Name:DEFB136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:34433. DEFB136.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 7857Beta-defensin 136PRO_0000045364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi40 ↔ 54By similarity
Disulfide bondi44 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KP8.

Expressioni

Gene expression databases

GenevestigatoriQ30KP8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371644.

Structurei

3D structure databases

ProteinModelPortaliQ30KP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140158.
GeneTreeiENSGT00390000001862.
HOGENOMiHOG000112165.
HOVERGENiHBG069057.
InParanoidiQ30KP8.
OMAiPPQAKDP.
OrthoDBiEOG7KH9NK.
PhylomeDBiQ30KP8.
TreeFamiTF343350.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW
60 70
IAFCHNILSC CKNMTRFQPP QAKDPWVH
Length:78
Mass (Da):8,755
Last modified:December 6, 2005 - v1
Checksum:i26F291E8E0EF3A40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012026 mRNA. Translation: AAY59762.1.
AY621333 mRNA. Translation: AAT51872.1.
CCDSiCCDS43709.1.
RefSeqiNP_001028190.2. NM_001033018.2.
UniGeneiHs.558285.

Genome annotation databases

EnsembliENST00000382209; ENSP00000371644; ENSG00000205884.
GeneIDi613210.
KEGGihsa:613210.
UCSCiuc011kxm.2. human.

Polymorphism databases

DMDMi84028899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ012026 mRNA. Translation: AAY59762.1 .
AY621333 mRNA. Translation: AAT51872.1 .
CCDSi CCDS43709.1.
RefSeqi NP_001028190.2. NM_001033018.2.
UniGenei Hs.558285.

3D structure databases

ProteinModelPortali Q30KP8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000371644.

Polymorphism databases

DMDMi 84028899.

Proteomic databases

PRIDEi Q30KP8.

Protocols and materials databases

DNASUi 613210.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000382209 ; ENSP00000371644 ; ENSG00000205884 .
GeneIDi 613210.
KEGGi hsa:613210.
UCSCi uc011kxm.2. human.

Organism-specific databases

CTDi 613210.
GeneCardsi GC08M011831.
HGNCi HGNC:34433. DEFB136.
neXtProti NX_Q30KP8.
PharmGKBi PA165585543.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG140158.
GeneTreei ENSGT00390000001862.
HOGENOMi HOG000112165.
HOVERGENi HBG069057.
InParanoidi Q30KP8.
OMAi PPQAKDP.
OrthoDBi EOG7KH9NK.
PhylomeDBi Q30KP8.
TreeFami TF343350.

Enzyme and pathway databases

Reactomei REACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii 613210.
NextBioi 112841.
PROi Q30KP8.

Gene expression databases

Genevestigatori Q30KP8.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.

Entry informationi

Entry nameiDB136_HUMAN
AccessioniPrimary (citable) accession number: Q30KP8
Secondary accession number(s): Q4QY36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed () DEFB137.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3