Q30KP8 (DB136_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-defensin 136

Alternative name(s):
Defensin, beta 136

Gene names

Name:

DEFB136

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Has antibacterial activity Potential.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the beta-defensin family.
Caution	Was termed (Ref.2) DEFB137.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antibiotic Antimicrobial Defensin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 78	57	Beta-defensin 136		PRO_0000045364
Amino acid modifications
	Disulfide bond	33 ↔ 60		By similarity
	Disulfide bond	40 ↔ 54		By similarity
	Disulfide bond	44 ↔ 61		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q30KP8 [UniParc]. Last modified December 6, 2005. Version 1. Checksum: 26F291E8E0EF3A40	FASTA	78	8,755
	10 20 30 40 50 60 MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW IAFCHNILSC 70 CKNMTRFQPP QAKDPWVH

References

[1]	"Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract." Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G. Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals." Patil A., Zhang G. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ012026 mRNA. Translation: AAY59762.1. AY621333 mRNA. Translation: AAT51872.1.
IPI	IPI00607876.
RefSeq	NP_001028190.2. NM_001033018.2.
UniGene	Hs.558285.
3D structure databases
ProteinModelPortal	Q30KP8.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000371644.
Polymorphism databases
DMDM	84028899.
Proteomic databases
PRIDE	Q30KP8.
Protocols and materials databases
DNASU	613210.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000382209; ENSP00000371644; ENSG00000205884.
GeneID	613210.
KEGG	hsa:613210.
UCSC	uc011kxm.2. human.
Organism-specific databases
CTD	613210.
GeneCards	GC08M011831.
HGNC	HGNC:34433. DEFB136.
neXtProt	NX_Q30KP8.
PharmGKB	PA165585543.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG140158.
HOGENOM	HOG000112165.
HOVERGEN	HBG069057.
InParanoid	Q30KP8.
OMA	FCHNILS.
OrthoDB	EOG44J2KT.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
Genevestigator	Q30KP8.
Family and domain databases
ProtoNet	Search...
Other
NextBio	112841.

Entry information

Entry name

DB136_HUMAN

Accession

Primary (citable) accession number: Q30KP8
Secondary accession number(s): Q4QY36

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	December 6, 2005
Last modified:	April 3, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.