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Protein

Beta-defensin 136

Gene

DEFB136

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.Curated

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Defensin

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-defensin 136
Alternative name(s):
Defensin, beta 136
Gene namesi
Name:DEFB136
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:34433. DEFB136.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165585543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 7857Beta-defensin 136PRO_0000045364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 ↔ 60By similarity
Disulfide bondi40 ↔ 54By similarity
Disulfide bondi44 ↔ 61By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ30KP8.

Expressioni

Gene expression databases

GenevestigatoriQ30KP8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000371644.

Structurei

3D structure databases

ProteinModelPortaliQ30KP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-defensin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG140158.
GeneTreeiENSGT00390000001862.
HOGENOMiHOG000112165.
HOVERGENiHBG069057.
InParanoidiQ30KP8.
OMAiFCHNILS.
OrthoDBiEOG7KH9NK.
PhylomeDBiQ30KP8.
TreeFamiTF343350.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q30KP8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLCLSALLF FLVILLPSGK GMFGNDGVKV RTCTSQKAVC FFGCPPGYRW
60 70
IAFCHNILSC CKNMTRFQPP QAKDPWVH
Length:78
Mass (Da):8,755
Last modified:December 6, 2005 - v1
Checksum:i26F291E8E0EF3A40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012026 mRNA. Translation: AAY59762.1.
AY621333 mRNA. Translation: AAT51872.1.
CCDSiCCDS43709.1.
RefSeqiNP_001028190.2. NM_001033018.2.
UniGeneiHs.558285.

Genome annotation databases

EnsembliENST00000382209; ENSP00000371644; ENSG00000205884.
GeneIDi613210.
KEGGihsa:613210.
UCSCiuc011kxm.2. human.

Polymorphism databases

DMDMi84028899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ012026 mRNA. Translation: AAY59762.1.
AY621333 mRNA. Translation: AAT51872.1.
CCDSiCCDS43709.1.
RefSeqiNP_001028190.2. NM_001033018.2.
UniGeneiHs.558285.

3D structure databases

ProteinModelPortaliQ30KP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000371644.

Polymorphism databases

DMDMi84028899.

Proteomic databases

PRIDEiQ30KP8.

Protocols and materials databases

DNASUi613210.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000382209; ENSP00000371644; ENSG00000205884.
GeneIDi613210.
KEGGihsa:613210.
UCSCiuc011kxm.2. human.

Organism-specific databases

CTDi613210.
GeneCardsiGC08M011831.
HGNCiHGNC:34433. DEFB136.
neXtProtiNX_Q30KP8.
PharmGKBiPA165585543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG140158.
GeneTreeiENSGT00390000001862.
HOGENOMiHOG000112165.
HOVERGENiHBG069057.
InParanoidiQ30KP8.
OMAiFCHNILS.
OrthoDBiEOG7KH9NK.
PhylomeDBiQ30KP8.
TreeFamiTF343350.

Enzyme and pathway databases

ReactomeiREACT_115846. Defensins.
REACT_115897. Beta defensins.

Miscellaneous databases

GenomeRNAii613210.
NextBioi112841.
PROiQ30KP8.

Gene expression databases

GenevestigatoriQ30KP8.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract."
    Patil A.A., Cai Y., Sang Y., Blecha F., Zhang G.
    Physiol. Genomics 23:5-17(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genome-wide analysis of rat beta-defensins: evidence for the existence of four syntenic defensin gene clusters in mammals."
    Patil A., Zhang G.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-73.

Entry informationi

Entry nameiDB136_HUMAN
AccessioniPrimary (citable) accession number: Q30KP8
Secondary accession number(s): Q4QY36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 6, 2005
Last modified: January 7, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was termed () DEFB137.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.