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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDH-Fp

Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDH-Fp)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDH-FpImported
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

EuPathDBiToxoDB:TGME49_215590

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ309Z9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 477FAD_binding_2InterPro annotationAdd BLAST403
Domaini532 – 669Succ_DH_flav_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q309Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHASASLTQA LRPYARRPLS SALSRSSLSP ALAAGVARGL NAAQPQATGP
60 70 80 90 100
SFVQQKRFFT NVKKPAYRVI DHEYDAIVVG AGGAGLRAAF GLASAGIKTA
110 120 130 140 150
CLSKLFPTRS HTVAAQGGIN AALGNMTEDD WRWHAYDTVK GSDWLGDQDA
160 170 180 190 200
IQHMCREAPK VVRELESYGL PFSRTEDGRI YQRAFGGQSL RFGKGGQAYR
210 220 230 240 250
CAAAADRTGH AMLHSLYGQS LAHDCKFFVE YFALDLMMSG ENDERKCHGV
260 270 280 290 300
VAMCMEDGSI HRFAAKHTVL ATGGYGRAYQ SCTSAHTCTG DGGGMVSRAG
310 320 330 340 350
LPLEDLEFVQ FHPTGIFPAG CLITEGCRGE GGILRNGQGE AFMARYAPTA
360 370 380 390 400
KDLASRDVVS RSMTIEIREG RGCGPNRDHM HLDLTHLPPA TLHERLPGIT
410 420 430 440 450
ETAKIFAGVN AEKEPIPVLP TVHYNMGGIP TNWRAQVLTT SRSKAGGPDK
460 470 480 490 500
IVQGLYAAGE AACASVHGAN RLGANSLLDL VVFGREAART IADECKKDAS
510 520 530 540 550
APSLPPNAGE ETLAMVDRLR HSNGPLTTAQ IRQRMQKTMQ DHAAVFRTGA
560 570 580 590 600
VLREGVEMMK DVAKSFADVG VKDRSLSWNT DLIETLELQN LLTQAVQTIV
610 620 630 640 650
GAEARKESRG AHAREDFKER DDKNWMKHTL SWQTHREVEK AEFPLTYRQV
660
ISQPLDNEME HIPPAKRVY
Length:669
Mass (Da):72,751
Last modified:December 6, 2005 - v1
Checksum:iC56BB44C3B997CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228958 mRNA Translation: ABB17193.1

Similar proteinsi

Entry informationi

Entry nameiQ309Z9_TOXGO
AccessioniPrimary (citable) accession number: Q309Z9
Secondary accession number(s): B6KSQ5, S8EZA4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: March 28, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health