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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

SDH-Fp

Organism
Toxoplasma gondii
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDH-Fp), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (TGVEG_215590), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (TGVEG_215280)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:SDH-FpImported
OrganismiToxoplasma gondiiImported
Taxonomic identifieri5811 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaConoidasidaCoccidiaEucoccidioridaEimeriorinaSarcocystidaeToxoplasma

Organism-specific databases

EuPathDBiToxoDB:TGME49_215590.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

MembraneUniRule annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242 PotentialImportedAdd
BLAST
Chaini43 – 669627 PotentialImportedPRO_5000140730Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5811.TGME49_015590.

Structurei

3D structure databases

ProteinModelPortaliQ309Z9.
SMRiQ309Z9. Positions 67-669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

SignalImported, Transit peptideUniRule annotation

Phylogenomic databases

OMAiKWRTCFT.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q309Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHASASLTQA LRPYARRPLS SALSRSSLSP ALAAGVARGL NAAQPQATGP
60 70 80 90 100
SFVQQKRFFT NVKKPAYRVI DHEYDAIVVG AGGAGLRAAF GLASAGIKTA
110 120 130 140 150
CLSKLFPTRS HTVAAQGGIN AALGNMTEDD WRWHAYDTVK GSDWLGDQDA
160 170 180 190 200
IQHMCREAPK VVRELESYGL PFSRTEDGRI YQRAFGGQSL RFGKGGQAYR
210 220 230 240 250
CAAAADRTGH AMLHSLYGQS LAHDCKFFVE YFALDLMMSG ENDERKCHGV
260 270 280 290 300
VAMCMEDGSI HRFAAKHTVL ATGGYGRAYQ SCTSAHTCTG DGGGMVSRAG
310 320 330 340 350
LPLEDLEFVQ FHPTGIFPAG CLITEGCRGE GGILRNGQGE AFMARYAPTA
360 370 380 390 400
KDLASRDVVS RSMTIEIREG RGCGPNRDHM HLDLTHLPPA TLHERLPGIT
410 420 430 440 450
ETAKIFAGVN AEKEPIPVLP TVHYNMGGIP TNWRAQVLTT SRSKAGGPDK
460 470 480 490 500
IVQGLYAAGE AACASVHGAN RLGANSLLDL VVFGREAART IADECKKDAS
510 520 530 540 550
APSLPPNAGE ETLAMVDRLR HSNGPLTTAQ IRQRMQKTMQ DHAAVFRTGA
560 570 580 590 600
VLREGVEMMK DVAKSFADVG VKDRSLSWNT DLIETLELQN LLTQAVQTIV
610 620 630 640 650
GAEARKESRG AHAREDFKER DDKNWMKHTL SWQTHREVEK AEFPLTYRQV
660
ISQPLDNEME HIPPAKRVY
Length:669
Mass (Da):72,751
Last modified:December 6, 2005 - v1
Checksum:iC56BB44C3B997CE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228958 mRNA. Translation: ABB17193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ228958 mRNA. Translation: ABB17193.1.

3D structure databases

ProteinModelPortaliQ309Z9.
SMRiQ309Z9. Positions 67-669.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5811.TGME49_015590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

EuPathDBiToxoDB:TGME49_215590.

Phylogenomic databases

OMAiKWRTCFT.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of the respiratory chain components in Toxoplasma gondii."
    Saleh A.M., Bohne W.
    Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: RHImported.

Entry informationi

Entry nameiQ309Z9_TOXGO
AccessioniPrimary (citable) accession number: Q309Z9
Secondary accession number(s): B6KSQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 6, 2005
Last sequence update: December 6, 2005
Last modified: July 22, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.