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Protein
Submitted name:

MHC Class I heavy chain

Gene

EXMHCB1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC Class I heavy chainImported
Gene namesi
Name:EXMHCB1Imported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei303 – 325HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_500421936222 – 357Sequence analysisAdd BLAST336

Proteomic databases

PeptideAtlasiQ30482.

Interactioni

Subunit structurei

Heterodimer of an alpha chain and a beta chain (beta-2-microglobulin).SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ30482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini206 – 292Ig-likeInterPro annotationAdd BLAST87

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR037055. MHC_I-like_Ag-recog_sf.
IPR011162. MHC_I/II-like_Ag-recog.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
PRINTSiPR01638. MHCCLASSI.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q30482-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPPTFLLLL SGALTLTETW AGSHSMRYFY TVVSRPGRGE PRFIAVGYVD
60 70 80 90 100
DTQFVRFDSD AENPKEEPRA PWMEQEGPEY WERNTRIYKD TAQTYRENLR
110 120 130 140 150
IALGYYNQSE AGSHTLQWMY GCDVGPDGRL LRGYSQDAYD GADYIALNED
160 170 180 190 200
LRSWTAADAA AQITRRKWEA AGVAEHDRNY LEGTCVESLR RYLENGKETL
210 220 230 240 250
QRADPPKTHV THHPISDREV TLRCWALGFY PAEITLTWQH EGEDLTQDTE
260 270 280 290 300
FVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTRRWELPPQ
310 320 330 340 350
STILIVVIIA GLVLLGAVVA GAVMWRKKRS GEKRGIYVQA ANSDSAQGSD

ASLPQKV
Length:357
Mass (Da):40,360
Last modified:November 1, 1996 - v1
Checksum:iCB2E2EE4AFDBC9F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79890 mRNA. Translation: CAA56262.1.
RefSeqiNP_001075974.1. NM_001082505.1.
UniGeneiEca.2445.

Genome annotation databases

GeneIDi100034209.
KEGGiecb:100034209.

Similar proteinsi

Entry informationi

Entry nameiQ30482_HORSE
AccessioniPrimary (citable) accession number: Q30482
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)