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Q30265

- Q30265_BOVIN

UniProt

Q30265 - Q30265_BOVIN

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Protein
Submitted name:

BoLA-DR-alpha

Gene
BoLA-DRA
Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_202824. Translocation of ZAP-70 to Immunological synapse.
REACT_205423. Downstream TCR signaling.
REACT_211133. MHC class II antigen presentation.
REACT_212961. Phosphorylation of CD3 and TCR zeta chains.
REACT_213223. PD-1 signaling.
REACT_218413. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Submitted name:
BoLA-DR-alphaImported
Gene namesi
Name:BoLA-DRAImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. late endosome membrane Source: Ensembl
  3. lysosomal membrane Source: Ensembl
  4. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotations

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 238›238BoLa-DR-alphaImportedPRO_5000006465Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ30265.

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG006862.
InParanoidiQ30265.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q30265-1 [UniParc]FASTAAdd to Basket

« Hide

LIGLQESWAI KENHVIIQAE FYLKPEESAE FMFDFDGDEI FHVDMGKKET    50
VWRLPEFGHF ASFEAQGALA NMAVMKANLD IMIKRSNNTP NTNVPPEVTL 100
LPNKPVELGE PNTLICFIDK FSPPVISVTW LRNGKPVTDG VSQTVFLPRN 150
DHLFRKFHYL PFLPTTEDVY DCKVEHLGLN EPLLKHWEYE APAPLPETTE 200
NAVCALGLIV ALVGIIAGTI FIIKGVRKAN TVERRGPL 238
Length:238
Mass (Da):26,781
Last modified:November 1, 1996 - v1
Checksum:i68F450C6B959EC77
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37955 mRNA. Translation: BAA07172.1.
UniGeneiBt.8552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D37955 mRNA. Translation: BAA07172.1 .
UniGenei Bt.8552.

3D structure databases

ProteinModelPortali Q30265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006862.
InParanoidi Q30265.

Enzyme and pathway databases

Reactomei REACT_202824. Translocation of ZAP-70 to Immunological synapse.
REACT_205423. Downstream TCR signaling.
REACT_211133. MHC class II antigen presentation.
REACT_212961. Phosphorylation of CD3 and TCR zeta chains.
REACT_213223. PD-1 signaling.
REACT_218413. Generation of second messenger molecules.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of cDNAs and the molecular evolution of a bovine MHC class II DRA gene."
    Aida Y., Kohda C., Morooka A., Nakai Y., Ogimoto K., Urao T., Asahina M.
    Biochem. Biophys. Res. Commun. 204:195-202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Japanese BlackImported.
    Tissue: Tumor lymph nodeImported.

Entry informationi

Entry nameiQ30265_BOVIN
AccessioniPrimary (citable) accession number: Q30265
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 3, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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