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Q30265

- Q30265_BOVIN

UniProt

Q30265 - Q30265_BOVIN

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Protein
Submitted name:

BoLA-DR-alpha

Gene

BoLA-DRA

Organism
Bos taurus (Bovine)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. peptide antigen binding Source: Ensembl

GO - Biological processi

  1. cognition Source: Ensembl
  2. immune response Source: InterPro
  3. peptide antigen assembly with MHC class II protein complex Source: Ensembl
  4. polysaccharide assembly with MHC class II protein complex Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiREACT_202824. Translocation of ZAP-70 to Immunological synapse.
REACT_205423. Downstream TCR signaling.
REACT_211133. MHC class II antigen presentation.
REACT_212961. Phosphorylation of CD3 and TCR zeta chains.
REACT_213223. PD-1 signaling.
REACT_218413. Generation of second messenger molecules.

Names & Taxonomyi

Protein namesi
Submitted name:
BoLA-DR-alphaImported
Gene namesi
Name:BoLA-DRAImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome membrane Source: Ensembl
  5. lysosomal membrane Source: Ensembl
  6. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 238›238BoLa-DR-alphaImportedPRO_5000006465Add
BLAST

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

ExpressionAtlasiQ30265. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ30265.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q30265-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LIGLQESWAI KENHVIIQAE FYLKPEESAE FMFDFDGDEI FHVDMGKKET
60 70 80 90 100
VWRLPEFGHF ASFEAQGALA NMAVMKANLD IMIKRSNNTP NTNVPPEVTL
110 120 130 140 150
LPNKPVELGE PNTLICFIDK FSPPVISVTW LRNGKPVTDG VSQTVFLPRN
160 170 180 190 200
DHLFRKFHYL PFLPTTEDVY DCKVEHLGLN EPLLKHWEYE APAPLPETTE
210 220 230
NAVCALGLIV ALVGIIAGTI FIIKGVRKAN TVERRGPL
Length:238
Mass (Da):26,781
Last modified:November 1, 1996 - v1
Checksum:i68F450C6B959EC77
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37955 mRNA. Translation: BAA07172.1.
UniGeneiBt.8552.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D37955 mRNA. Translation: BAA07172.1 .
UniGenei Bt.8552.

3D structure databases

ProteinModelPortali Q30265.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006862.

Enzyme and pathway databases

Reactomei REACT_202824. Translocation of ZAP-70 to Immunological synapse.
REACT_205423. Downstream TCR signaling.
REACT_211133. MHC class II antigen presentation.
REACT_212961. Phosphorylation of CD3 and TCR zeta chains.
REACT_213223. PD-1 signaling.
REACT_218413. Generation of second messenger molecules.

Gene expression databases

ExpressionAtlasi Q30265. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of cDNAs and the molecular evolution of a bovine MHC class II DRA gene."
    Aida Y., Kohda C., Morooka A., Nakai Y., Ogimoto K., Urao T., Asahina M.
    Biochem. Biophys. Res. Commun. 204:195-202(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Japanese BlackImported.
    Tissue: Tumor lymph nodeImported.

Entry informationi

Entry nameiQ30265_BOVIN
AccessioniPrimary (citable) accession number: Q30265
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)