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Reviewed, UniProtKB/Swiss-Prot Q30167 (2B1A_HUMAN)

Last modified February 9, 2010. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    HLA class II histocompatibility antigen, DRB1-10 beta chain
Alternative name(s):
    MHC class II antigen DRB1*10
    DRw10
Gene names
Name: HLA-DRB1
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length266 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Subunit structure

Heterodimer of an alpha chain and a beta chain.

Subcellular location

Membrane; Single-pass type I membrane protein.

Polymorphism

The only allele of DRB1-10 known is DRB1*1001 which is shown here.

Sequence similarities

Belongs to the MHC class II family.

Contains 1 Ig-like C1-type (immunoglobulin-like) domain.

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Ontologies

Keywords
   Biological processImmune response
   Cellular componentMHC II
Membrane
   Coding sequence diversityPolymorphism
   DomainSignal
Transmembrane
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processantigen processing and presentation of peptide or polysaccharide antigen via MHC class II

Inferred from electronic annotation. Source: UniProtKB-KW

immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentMHC class II protein complex

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929
Chain30 – 266237HLA class II histocompatibility antigen, DRB1-10 beta chain
PRO_0000018954

Regions

Topological domain30 – 227198Extracellular Potential
Transmembrane228 – 25023 Potential
Topological domain251 – 26616Cytoplasmic Potential
Domain126 – 21691Ig-like C1-type
Region30 – 12495Beta-1
Region125 – 227103Beta-2

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Disulfide bond44 ↔ 108 By similarity
Disulfide bond146 ↔ 202 By similarity

Natural variations

Natural variant2361V → M: dbSNP rs2230816.
VAR_056540
Natural variant2621T → R: dbSNP rs9269744.
VAR_056541

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Sequences

Sequence LengthMass (Da)Tools
Q30167-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 378B630DA8C214E5

FASTA26630,074
        10         20         30         40         50         60 
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEEV KFECHFFNGT ERVRLLERRV 

        70         80         90        100        110        120 
HNQEEYARYD SDVGEYRAVT ELGRPDAEYW NSQKDLLERR RAAVDTYCRH NYGVGESFTV 

       130        140        150        160        170        180 
QRRVQPKVTV YPSKTQPLQH HNLLVCSVNG FYPGSIEVRW FRNGQEEKTG VVSTGLIQNE 

       190        200        210        220        230        240 
DWTFQTLVML ETVPQSGEVY TCQVEHPSVM SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 

       250        260 
FLGAGLFIYF RNQKGHSGLP PTGFLS

« Hide

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References

[1]"Nucleotide sequence of a DRw10 beta chain cDNA clone. Identity of the third D region with that of the DRw53 allele of the beta 2 locus and as the probable site encoding a polymorphic MHC class II epitope."
Merryman P., Gregersen P.K., Lee S., Silver J., Nunez-Roldan A., Crapper R., Winchester R.
J. Immunol. 140:2447-2452(1988) [PubMed: 2450924] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (DRB1*1001).
[2]"Sequence of an HLA-DRB gene."
Woelpl A.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-123 (DRB1*1001).
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M20138 mRNA. Translation: AAA59832.1.
AF225565 Genomic DNA. Translation: AAF65542.1.
IPIIPI00473139.
UniGeneHs.534322
Hs.701691

3D structure databases

SMRQ30167. Positions 30-221.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ30167.

Proteomic databases

PRIDEQ30167.

Genome annotation databases

EnsemblENST00000419393; ENSP00000403458; ENSG00000228080; Homo sapiens. [Genome view]
ENST00000450362; ENSP00000410118; ENSG00000228080; Homo sapiens. [Genome view]

Organism-specific databases

GeneCardsGC06M032656.
GC06Mc32600.
GC06Mf32600.
H-InvDBHIX0019690.
HGNCHGNC:4948. HLA-DRB1.
MIM142857. gene.
Orphanet797. Sarcoidosis.
PharmGKBPA35072.
GenAtlasSearch...

Phylogenomic databases

HOVERGENQ30167.

Gene expression databases

ArrayExpressQ30167.
BgeeQ30167.
CleanExHS_HLA-DRB1.
GenevestigatorQ30167.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR000353. MHC_II_b_N.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PfamPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry name2B1A_HUMAN
AccessionPrimary (citable) accession number: Q30167
Secondary accession number(s): Q9MYF5
Entry history
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: November 1, 1996
Last modified: February 9, 2010
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents