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Protein
Submitted name:

HLA class II histocompatibility antigen, DR alpha chain

Gene

HLA-DRA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DR alpha chainImported
Submitted name:
MHC cell surface glycoproteinImported
Gene namesi
Name:HLA-DRAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204287.13
HGNCiHGNC:4947 HLA-DRA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 217HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_501410439826 – 229Sequence analysisAdd BLAST204

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ30118
PeptideAtlasiQ30118

Expressioni

Gene expression databases

BgeeiENSG00000204287

Structurei

3D structure databases

SMRiQ30118
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 109MHC_II_alphaInterPro annotationAdd BLAST80
Domaini110 – 173IGc1InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00900000140882
HOVERGENiHBG006862

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR001003 MHC_II_a_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00993 MHC_II_alpha, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00920 MHC_II_alpha, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q30118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD
60 70 80 90 100
FDGDEIFHVD MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK
110 120 130 140 150
RSNYTPITND KFTPPVVNVT WLRNGKPVTT GVSETVFLPR EDHLFRKFHY
160 170 180 190 200
LPFLPSTEDV YDCRVEHWGL DEPLLKHWEF DAPSPLPETT ENVVCALGLT
210 220
VGLVGIIIGT IFIIKGLRKS NAAERRGPL
Length:229
Mass (Da):25,860
Last modified:November 1, 1996 - v1
Checksum:i1FAD7B101F65335C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662796 Genomic DNA No translation available.
AL670296 Genomic DNA No translation available.
M60333 mRNA Translation: AAA59787.1
UniGeneiHs.520048

Genome annotation databases

EnsembliENST00000374982; ENSP00000364121; ENSG00000204287
ENST00000434866; ENSP00000403385; ENSG00000227993
UCSCiuc003obi.5 human

Similar proteinsi

Entry informationi

Entry nameiQ30118_HUMAN
AccessioniPrimary (citable) accession number: Q30118
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health