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Protein
Submitted name:

HLA class II histocompatibility antigen, DR alpha chain

Gene

HLA-DRA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DR alpha chainImported
Submitted name:
MHC cell surface glycoproteinImported
Gene namesi
Name:HLA-DRAImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:4947. HLA-DRA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei196 – 217HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000204287.
ENSG00000227993.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500770170926 – 229Sequence analysisAdd BLAST204

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ30118.
PeptideAtlasiQ30118.
PRIDEiQ30118.

Expressioni

Gene expression databases

BgeeiENSG00000204287.
ExpressionAtlasiQ30118. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ30118.
SMRiQ30118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 109MHC_II_alphaInterPro annotationAdd BLAST80
Domaini110 – 173IGc1InterPro annotationAdd BLAST64

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118970.
HOVERGENiHBG006862.
PhylomeDBiQ30118.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q30118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAISGVPVLG FFIIAVLMSA QESWAIKEEH VIIQAEFYLN PDQSGEFMFD
60 70 80 90 100
FDGDEIFHVD MAKKETVWRL EEFGRFASFE AQGALANIAV DKANLEIMTK
110 120 130 140 150
RSNYTPITND KFTPPVVNVT WLRNGKPVTT GVSETVFLPR EDHLFRKFHY
160 170 180 190 200
LPFLPSTEDV YDCRVEHWGL DEPLLKHWEF DAPSPLPETT ENVVCALGLT
210 220
VGLVGIIIGT IFIIKGLRKS NAAERRGPL
Length:229
Mass (Da):25,860
Last modified:November 1, 1996 - v1
Checksum:i1FAD7B101F65335C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662796 Genomic DNA. No translation available.
AL670296 Genomic DNA. No translation available.
M60333 mRNA. Translation: AAA59787.1.
UniGeneiHs.520048.

Genome annotation databases

EnsembliENST00000374982; ENSP00000364121; ENSG00000204287.
ENST00000434866; ENSP00000403385; ENSG00000227993.
UCSCiuc003obi.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662796 Genomic DNA. No translation available.
AL670296 Genomic DNA. No translation available.
M60333 mRNA. Translation: AAA59787.1.
UniGeneiHs.520048.

3D structure databases

ProteinModelPortaliQ30118.
SMRiQ30118.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiQ30118.
PeptideAtlasiQ30118.
PRIDEiQ30118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000374982; ENSP00000364121; ENSG00000204287.
ENST00000434866; ENSP00000403385; ENSG00000227993.
UCSCiuc003obi.5. human.

Organism-specific databases

HGNCiHGNC:4947. HLA-DRA.
OpenTargetsiENSG00000204287.
ENSG00000227993.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118970.
HOVERGENiHBG006862.
PhylomeDBiQ30118.

Miscellaneous databases

ChiTaRSiHLA-DRA. human.

Gene expression databases

BgeeiENSG00000204287.
ExpressionAtlasiQ30118. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ30118_HUMAN
AccessioniPrimary (citable) accession number: Q30118
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.