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Q30066

- Q30066_HUMAN

UniProt

Q30066 - Q30066_HUMAN

Protein
Submitted name:

MHC class II HLA-DQ-alpha chain

Gene

HLA-DQA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class II HLA-DQ-alpha chainImported
    Gene namesi
    Name:HLA-DQA1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class II protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC IISAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    ArrayExpressiQ30066.
    BgeeiQ30066.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GRLX-ray2.86A2-184[»]
    4MAYX-ray2.20A2-184[»]
    ProteinModelPortaliQ30066.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ30066.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class II family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG006862.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q30066-1 [UniParc]FASTAAdd to Basket

    « Hide

    EDIVADHVAS CGVNLYQFYG PSGQYTHEFD GDEQFYVDLE RKETAWRWPE    50
    FSKFGGFDPQ GALRNMAVAK HNLNIMIKRY NSTAATNEVP EVTVFSKSPV 100
    TLGQPNTLIC LVDNIFPPVV NITWLSNGQS VTEGVSETSF LSKSDHSFFK 150
    ISYLTFLPSA DEIYDCKVEH WGLDQPLLKH WEPEIPAPMS ELTETVVCAL 200
    GLSVGLMGIV VGTVFIIQGL RSVGASR 227
    Length:227
    Mass (Da):25,198
    Last modified:November 1, 1996 - v1
    Checksum:iFC546FA807D36161
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei227 – 2271Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34084 mRNA. Translation: AAC41952.1.
    UniGeneiHs.387679.
    Hs.591798.
    Hs.706240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L34084 mRNA. Translation: AAC41952.1 .
    UniGenei Hs.387679.
    Hs.591798.
    Hs.706240.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GRL X-ray 2.86 A 2-184 [» ]
    4MAY X-ray 2.20 A 2-184 [» ]
    ProteinModelPortali Q30066.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG006862.

    Miscellaneous databases

    ChiTaRSi HLA-DQA1. human.
    EvolutionaryTracei Q30066.

    Gene expression databases

    ArrayExpressi Q30066.
    Bgeei Q30066.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR001003. MHC_II_a_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00993. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00920. MHC_II_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
      Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
      Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop."
      Sethi D.K., Gordo S., Schubert D.A., Wucherpfennig K.W.
      Nat. Commun. 4:2623-2623(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-184.

    Entry informationi

    Entry nameiQ30066_HUMAN
    AccessioniPrimary (citable) accession number: Q30066
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3