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Q30066

- Q30066_HUMAN

UniProt

Q30066 - Q30066_HUMAN

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Protein
Submitted name:

MHC class II HLA-DQ-alpha chain

Gene

HLA-DQA1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II HLA-DQ-alpha chainImported
Gene namesi
Name:HLA-DQA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiQ30066.
ExpressionAtlasiQ30066. baseline and differential.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GRLX-ray2.86A2-184[»]
4MAYX-ray2.20A2-184[»]
ProteinModelPortaliQ30066.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ30066.

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q30066-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
EDIVADHVAS CGVNLYQFYG PSGQYTHEFD GDEQFYVDLE RKETAWRWPE
60 70 80 90 100
FSKFGGFDPQ GALRNMAVAK HNLNIMIKRY NSTAATNEVP EVTVFSKSPV
110 120 130 140 150
TLGQPNTLIC LVDNIFPPVV NITWLSNGQS VTEGVSETSF LSKSDHSFFK
160 170 180 190 200
ISYLTFLPSA DEIYDCKVEH WGLDQPLLKH WEPEIPAPMS ELTETVVCAL
210 220
GLSVGLMGIV VGTVFIIQGL RSVGASR
Length:227
Mass (Da):25,198
Last modified:November 1, 1996 - v1
Checksum:iFC546FA807D36161
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei227 – 2271Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34084 mRNA. Translation: AAC41952.1.
UniGeneiHs.387679.
Hs.591798.
Hs.706240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34084 mRNA. Translation: AAC41952.1 .
UniGenei Hs.387679.
Hs.591798.
Hs.706240.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GRL X-ray 2.86 A 2-184 [» ]
4MAY X-ray 2.20 A 2-184 [» ]
ProteinModelPortali Q30066.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006862.

Miscellaneous databases

ChiTaRSi HLA-DQA1. human.
EvolutionaryTracei Q30066.

Gene expression databases

Bgeei Q30066.
ExpressionAtlasi Q30066. baseline and differential.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
    Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
    Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop."
    Sethi D.K., Gordo S., Schubert D.A., Wucherpfennig K.W.
    Nat. Commun. 4:2623-2623(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-184, ACTIVE SITE.

Entry informationi

Entry nameiQ30066_HUMAN
AccessioniPrimary (citable) accession number: Q30066
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3