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Q30066

- Q30066_HUMAN

UniProt

Q30066 - Q30066_HUMAN

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Protein
Submitted name: MHC class II HLA-DQ-alpha chain
Gene
HLA-DQA1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II HLA-DQ-alpha chainImported
Gene namesi
Name:HLA-DQA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MHC class II protein complex Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiQ30066.
BgeeiQ30066.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GRLX-ray2.86A2-184[»]
4MAYX-ray2.20A2-184[»]
ProteinModelPortaliQ30066.

Miscellaneous databases

EvolutionaryTraceiQ30066.

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q30066-1 [UniParc]FASTAAdd to Basket

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EDIVADHVAS CGVNLYQFYG PSGQYTHEFD GDEQFYVDLE RKETAWRWPE    50
FSKFGGFDPQ GALRNMAVAK HNLNIMIKRY NSTAATNEVP EVTVFSKSPV 100
TLGQPNTLIC LVDNIFPPVV NITWLSNGQS VTEGVSETSF LSKSDHSFFK 150
ISYLTFLPSA DEIYDCKVEH WGLDQPLLKH WEPEIPAPMS ELTETVVCAL 200
GLSVGLMGIV VGTVFIIQGL RSVGASR 227
Length:227
Mass (Da):25,198
Last modified:November 1, 1996 - v1
Checksum:iFC546FA807D36161
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei227 – 2271Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34084 mRNA. Translation: AAC41952.1.
UniGeneiHs.387679.
Hs.591798.
Hs.706240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L34084 mRNA. Translation: AAC41952.1 .
UniGenei Hs.387679.
Hs.591798.
Hs.706240.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GRL X-ray 2.86 A 2-184 [» ]
4MAY X-ray 2.20 A 2-184 [» ]
ProteinModelPortali Q30066.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG006862.

Miscellaneous databases

ChiTaRSi HLA-DQA1. human.
EvolutionaryTracei Q30066.

Gene expression databases

ArrayExpressi Q30066.
Bgeei Q30066.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view ]
SMARTi SM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
    Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
    Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop."
    Sethi D.K., Gordo S., Schubert D.A., Wucherpfennig K.W.
    Nat. Commun. 4:2623-2623(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-184.

Entry informationi

Entry nameiQ30066_HUMAN
AccessioniPrimary (citable) accession number: Q30066
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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