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Q30066 (Q30066_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:HLA-DQA1 EMBL AAC41952.1
OrganismHomo sapiens (Human) EMBL AAC41952.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length227 AA.
Sequence statusFragment.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the MHC class II family. RuleBase RU004238

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS014745

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAC41952.1
Non-terminal residue2271 EMBL AAC41952.1

Sequences

Sequence LengthMass (Da)Tools
Q30066 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FC546FA807D36161

FASTA22725,198
        10         20         30         40         50         60 
EDIVADHVAS CGVNLYQFYG PSGQYTHEFD GDEQFYVDLE RKETAWRWPE FSKFGGFDPQ 

        70         80         90        100        110        120 
GALRNMAVAK HNLNIMIKRY NSTAATNEVP EVTVFSKSPV TLGQPNTLIC LVDNIFPPVV 

       130        140        150        160        170        180 
NITWLSNGQS VTEGVSETSF LSKSDHSFFK ISYLTFLPSA DEIYDCKVEH WGLDQPLLKH 

       190        200        210        220 
WEPEIPAPMS ELTETVVCAL GLSVGLMGIV VGTVFIIQGL RSVGASR 

« Hide

References

[1]"Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)."
Yasunaga S., Kimura A., Hamaguchi K., Ronningen K.S., Sasazuki T.
Tissue Antigens 47:37-48(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop."
Sethi D.K., Gordo S., Schubert D.A., Wucherpfennig K.W.
Nat. Commun. 4:2623-2623(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-184.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34084 mRNA. Translation: AAC41952.1.
UniGeneHs.387679.
Hs.591798.
Hs.706240.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GRLX-ray2.86A2-184[»]
4MAYX-ray2.20A2-184[»]
ProteinModelPortalQ30066.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG006862.

Gene expression databases

ArrayExpressQ30066.
BgeeQ30066.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-DQA1. human.
EvolutionaryTraceQ30066.

Entry information

Entry nameQ30066_HUMAN
AccessionPrimary (citable) accession number: Q30066
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: March 19, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.