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Q2YYT9

- Y2178_STAAB

UniProt

Q2YYT9 - Y2178_STAAB

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Protein
Putative 2-hydroxyacid dehydrogenase SAB2178
Gene
SAB2178
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei236 – 2361 By similarity
Binding sitei260 – 2601NAD By similarity
Active sitei265 – 2651 By similarity
Active sitei283 – 2831Proton donor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi155 – 1562NAD By similarity
Nucleotide bindingi234 – 2363NAD By similarity
Nucleotide bindingi283 – 2864NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-2252-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-hydroxyacid dehydrogenase SAB2178 (EC:1.1.1.-)
Gene namesi
Ordered Locus Names:SAB2178
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001927: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Putative 2-hydroxyacid dehydrogenase SAB2178
PRO_0000312182Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273036.SAB2178.

Structurei

3D structure databases

ProteinModelPortaliQ2YYT9.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1052.
HOGENOMiHOG000136700.
OMAiRGPIMNE.
OrthoDBiEOG6VXFC3.

Family and domain databases

Gene3Di3.40.50.720. 2 hits.
InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YYT9-1 [UniParc]FASTAAdd to Basket

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MEKVYVAGAI PEVGLKLLQE HFEVEMYEGK GLVDKDTLIK GVKNATALIS    50
LLSTNVDKDV IDAGKDLKII ANYGAGFNNI DIEYAREKSI DVTNTPKAST 100
NATADLTIGL VLAIARRIVE GDQLSRTTGF DGWAPLFFRG REVSGKTIGI 150
IGLGEIGSAV ARRARAFDMD VLYTGPNRKE EKEREIGAKY VDLDTLLKNA 200
DFITINAAYN PKMHHLIDTE QFKMMKSTAY LINASRGPIV HEQALVQALK 250
DNEIEGAALD VYEFEPDITD DLKSLNNVVL TPHIGNATFE ARDMMSKIVA 300
NAAISAVQGE KPQFVVN 317
Length:317
Mass (Da):34,689
Last modified:December 20, 2005 - v1
Checksum:i49D41FDFA2A10B07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ938182 Genomic DNA. Translation: CAI81867.1.
RefSeqiYP_417635.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81867; CAI81867; SAB2178.
GeneIDi3793607.
KEGGisab:SAB2178.
PATRICi19525397. VBIStaAur92441_2294.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ938182 Genomic DNA. Translation: CAI81867.1 .
RefSeqi YP_417635.1. NC_007622.1.

3D structure databases

ProteinModelPortali Q2YYT9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273036.SAB2178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI81867 ; CAI81867 ; SAB2178 .
GeneIDi 3793607.
KEGGi sab:SAB2178.
PATRICi 19525397. VBIStaAur92441_2294.

Phylogenomic databases

eggNOGi COG1052.
HOGENOMi HOG000136700.
OMAi RGPIMNE.
OrthoDBi EOG6VXFC3.

Enzyme and pathway databases

BioCyci SAUR273036:GJVS-2252-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 2 hits.
InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00389. 2-Hacid_dh. 1 hit.
PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiY2178_STAAB
AccessioniPrimary (citable) accession number: Q2YYT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 20, 2005
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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