Q2YYT9 (Y2178_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative 2-hydroxyacid dehydrogenase SAB2178
EC=1.1.1.-

Gene names

Ordered Locus Names:

SAB2178

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Putative 2-hydroxyacid dehydrogenase SAB2178		PRO_0000312182
Regions
	Nucleotide binding	155 – 156	2	NAD By similarity
	Nucleotide binding	234 – 236	3	NAD By similarity
	Nucleotide binding	283 – 286	4	NAD By similarity
Sites
	Active site	236	1	By similarity
	Active site	265	1	By similarity
	Active site	283	1	Proton donor By similarity
	Binding site	260	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YYT9 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 49D41FDFA2A10B07	FASTA	317	34,689
	10 20 30 40 50 60 MEKVYVAGAI PEVGLKLLQE HFEVEMYEGK GLVDKDTLIK GVKNATALIS LLSTNVDKDV 70 80 90 100 110 120 IDAGKDLKII ANYGAGFNNI DIEYAREKSI DVTNTPKAST NATADLTIGL VLAIARRIVE 130 140 150 160 170 180 GDQLSRTTGF DGWAPLFFRG REVSGKTIGI IGLGEIGSAV ARRARAFDMD VLYTGPNRKE 190 200 210 220 230 240 EKEREIGAKY VDLDTLLKNA DFITINAAYN PKMHHLIDTE QFKMMKSTAY LINASRGPIV 250 260 270 280 290 300 HEQALVQALK DNEIEGAALD VYEFEPDITD DLKSLNNVVL TPHIGNATFE ARDMMSKIVA 310 NAAISAVQGE KPQFVVN

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI81867.1.
RefSeq	YP_417635.1. NC_007622.1.
3D structure databases
HSSP	HSSP built from PDB template 2DBZ based on UniProtKB O58320.
ProteinModelPortal	Q2YYT9.
ModBase	Search...
Protein-protein interaction databases
STRING	273036.SAB2178.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI81867; CAI81867; SAB2178.
GeneID	3793607.
KEGG	sab:SAB2178.
PATRIC	19525397. VBIStaAur92441_2294.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1052.
HOGENOM	HOG000136700.
OMA	GPIMNEA.
ProtClustDB	CLSK885881.
Enzyme and pathway databases
BioCyc	SAUR273036:GJVS-2252-MONOMER.
Family and domain databases
Gene3D	3.40.50.720. 2 hits.
InterPro	IPR006139. D-isomer_2_OHA_DH_cat_dom. IPR006140. D-isomer_2_OHA_DH_NAD-bd. IPR016040. NAD(P)-bd_dom. [Graphical view]
Pfam	PF00389. 2-Hacid_dh. 1 hit. PF02826. 2-Hacid_dh_C. 1 hit. [Graphical view]
PROSITE	PS00065. D_2_HYDROXYACID_DH_1. False negative. PS00670. D_2_HYDROXYACID_DH_2. False negative. PS00671. D_2_HYDROXYACID_DH_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Y2178_STAAB

Accession

Primary (citable) accession number: Q2YYT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program