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Q2YYT9

- Y2178_STAAB

UniProt

Q2YYT9 - Y2178_STAAB

Protein

Putative 2-hydroxyacid dehydrogenase SAB2178

Gene

SAB2178

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei236 – 2361By similarity
    Binding sitei260 – 2601NADBy similarity
    Active sitei265 – 2651By similarity
    Active sitei283 – 2831Proton donorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi155 – 1562NADBy similarity
    Nucleotide bindingi234 – 2363NADBy similarity
    Nucleotide bindingi283 – 2864NADBy similarity

    GO - Molecular functioni

    1. NAD binding Source: InterPro
    2. oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-2252-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative 2-hydroxyacid dehydrogenase SAB2178 (EC:1.1.1.-)
    Gene namesi
    Ordered Locus Names:SAB2178
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Putative 2-hydroxyacid dehydrogenase SAB2178PRO_0000312182Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273036.SAB2178.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YYT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1052.
    HOGENOMiHOG000136700.
    OMAiRGPIMNE.
    OrthoDBiEOG6VXFC3.

    Family and domain databases

    Gene3Di3.40.50.720. 2 hits.
    InterProiIPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YYT9-1 [UniParc]FASTAAdd to Basket

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    MEKVYVAGAI PEVGLKLLQE HFEVEMYEGK GLVDKDTLIK GVKNATALIS    50
    LLSTNVDKDV IDAGKDLKII ANYGAGFNNI DIEYAREKSI DVTNTPKAST 100
    NATADLTIGL VLAIARRIVE GDQLSRTTGF DGWAPLFFRG REVSGKTIGI 150
    IGLGEIGSAV ARRARAFDMD VLYTGPNRKE EKEREIGAKY VDLDTLLKNA 200
    DFITINAAYN PKMHHLIDTE QFKMMKSTAY LINASRGPIV HEQALVQALK 250
    DNEIEGAALD VYEFEPDITD DLKSLNNVVL TPHIGNATFE ARDMMSKIVA 300
    NAAISAVQGE KPQFVVN 317
    Length:317
    Mass (Da):34,689
    Last modified:December 20, 2005 - v1
    Checksum:i49D41FDFA2A10B07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81867.1.
    RefSeqiYP_417635.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI81867; CAI81867; SAB2178.
    GeneIDi3793607.
    KEGGisab:SAB2178.
    PATRICi19525397. VBIStaAur92441_2294.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81867.1 .
    RefSeqi YP_417635.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YYT9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB2178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI81867 ; CAI81867 ; SAB2178 .
    GeneIDi 3793607.
    KEGGi sab:SAB2178.
    PATRICi 19525397. VBIStaAur92441_2294.

    Phylogenomic databases

    eggNOGi COG1052.
    HOGENOMi HOG000136700.
    OMAi RGPIMNE.
    OrthoDBi EOG6VXFC3.

    Enzyme and pathway databases

    BioCyci SAUR273036:GJVS-2252-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 2 hits.
    InterProi IPR006139. D-isomer_2_OHA_DH_cat_dom.
    IPR006140. D-isomer_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF00389. 2-Hacid_dh. 1 hit.
    PF02826. 2-Hacid_dh_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiY2178_STAAB
    AccessioniPrimary (citable) accession number: Q2YYT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3