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Q2YYT1 (FDHL_STAAB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative formate dehydrogenase SAB2186c

EC=1.2.1.2
Gene names
Ordered Locus Names:SAB2186c
OrganismStaphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]
Taxonomic identifier273036 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length984 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Formate + NAD+ = CO2 + NADH.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 4 4Fe-4S clusters By similarity.

Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit By similarity.

Sequence similarities

In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 2 4Fe-4S ferredoxin-type domains.

Contains 1 4Fe-4S Mo/W bis-MGD-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 984984Putative formate dehydrogenase SAB2186c
PRO_0000304128

Regions

Domain3 – 79772Fe-2S ferredoxin-type
Domain138 – 165284Fe-4S ferredoxin-type 1
Domain181 – 211314Fe-4S ferredoxin-type 2
Domain257 – 313574Fe-4S Mo/W bis-MGD-type
Region252 – 984733Formate dehydrogenase

Sites

Metal binding371Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding481Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding511Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding631Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding951Iron-sulfur 2 (4Fe-4S); via tele nitrogen By similarity
Metal binding991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1091Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1471Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1501Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1531Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding1571Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1901Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1931Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding1961Iron-sulfur 4 (4Fe-4S) By similarity
Metal binding2001Iron-sulfur 3 (4Fe-4S) By similarity
Metal binding2641Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2671Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2711Iron-sulfur 5 (4Fe-4S) By similarity
Metal binding2991Iron-sulfur 5 (4Fe-4S) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YYT1 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: D9148E8BB9B4DA02

FASTA984111,309
        10         20         30         40         50         60 
MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT CTVEIDGKIE 

        70         80         90        100        110        120 
RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT VCDYNNGDCE IHNTMDAWGL 

       130        140        150        160        170        180 
QHQTYEYKEK PYEKDYGPFY RYDPNQCILC GRCVEACQDI EVNETIRIDW DREHPRVIWD 

       190        200        210        220        230        240 
NDVPINESSC VSCGQCATVC PCNAMMEVNM EGNAGYMTDT EPGSLAAMVD LTKKAEPGYG 

       250        260        270        280        290        300 
PLFAISDSEA EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 

       310        320        330        340        350        360 
KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG PDALSFISSS 

       370        380        390        400        410        420 
KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR TVGHGGDSGS IEDLEKAAMS 

       430        440        450        460        470        480 
VLIGTNTAEA HPVIASRMKR AQKLFGQKIH VFDIRKHEMA ERADRFYQPK PGTDLAWLSA 

       490        500        510        520        530        540 
VTKYIIDHDL HDKAFIEEWV EDFDEYYKSL ETFTMAFAEE ATGIPEAELI KFAEECAKAE 

       550        560        570        580        590        600 
SVVICWAMGI TQQDIGSDSS TAISNLLLVT GNYRRPSTGA YPLRGHNNVQ GCSDMGSMPD 

       610        620        630        640        650        660 
KITGYQSIEA DDIRAKFEKE YGVKLNPKVG KDNHEMVEGV HDGEIHSLYL YGEDTGIVDS 

       670        680        690        700        710        720 
NINFVQAAFE NLDFMVVQDE FLTFTATFAD VVLPASPSLE KDGTFTNTER RIQRLYQALK 

       730        740        750        760        770        780 
PLGESKPDWK IFQAIANKLG FDWNYKHPSE IMDEIARLTP LYAGVSYERL EGFNSLQWPV 

       790        800        810        820        830        840 
HPDGTDEPIL YLEGFNFDNG KAKLFPLSFD NYFKQDEVYD IHVNNGRLLE HFHEGNMTYQ 

       850        860        870        880        890        900 
TPMIKYKVPR AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 

       910        920        930        940        950        960 
NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIA KRGKSPLNPN NFRVNKKRHP 

       970        980 
QYSVQVQKKW ERPDYVFPGN QVDK 

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References

[1]"Molecular correlates of host specialization in Staphylococcus aureus."
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ938182 Genomic DNA. Translation: CAI81875.1.
RefSeqYP_417643.1. NC_007622.1.

3D structure databases

ProteinModelPortalQ2YYT1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273036.SAB2186c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI81875; CAI81875; SAB2186c.
GeneID3793615.
KEGGsab:SAB2186c.
PATRIC19525415. VBIStaAur92441_2303.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3383.
HOGENOMHOG000031440.
KOK00123.
OMANMFEAAL.
OrthoDBEOG6CVV7G.
ProtClustDBCLSK865103.

Enzyme and pathway databases

BioCycSAUR273036:GJVS-2260-MONOMER.

Family and domain databases

InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR001450. 4Fe4S-bd_dom.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR009010. Asp_de-COase-like_dom.
IPR006478. Formate_DH_asu.
IPR006657. MoPterin_dinucl-bd_dom.
IPR006656. Mopterin_OxRdtase.
IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
IPR006655. Mopterin_OxRdtase_prok_CS.
IPR027467. MopterinOxRdtase_cofactor_BS.
IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
[Graphical view]
PfamPF12838. Fer4_7. 1 hit.
PF04879. Molybdop_Fe4S4. 1 hit.
PF00384. Molybdopterin. 1 hit.
PF01568. Molydop_binding. 1 hit.
PF10588. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
PIRSFPIRSF036643. FDH_alpha. 1 hit.
SMARTSM00926. Molybdop_Fe4S4. 1 hit.
SM00929. NADH-G_4Fe-4S_3. 1 hit.
[Graphical view]
SUPFAMSSF50692. SSF50692. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR01591. Fdh-alpha. 1 hit.
PROSITEPS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFDHL_STAAB
AccessionPrimary (citable) accession number: Q2YYT1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 20, 2005
Last modified: February 19, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families