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Q2YYT1

- FDHL_STAAB

UniProt

Q2YYT1 - FDHL_STAAB

Protein

Putative formate dehydrogenase SAB2186c

Gene

SAB2186c

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Formate + NAD+ = CO2 + NADH.

    Cofactori

    Binds 1 2Fe-2S cluster.By similarity
    Binds 4 4Fe-4S clusters.By similarity
    Binds 1 molybdenum-bis(molybdopterin guanine dinucleotide) (Mo-bis-MGD) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi48 – 481Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi51 – 511Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi63 – 631Iron-sulfur 1 (2Fe-2S)By similarity
    Metal bindingi95 – 951Iron-sulfur 2 (4Fe-4S); via tele nitrogenBy similarity
    Metal bindingi99 – 991Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi102 – 1021Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi109 – 1091Iron-sulfur 2 (4Fe-4S)By similarity
    Metal bindingi147 – 1471Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi150 – 1501Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi153 – 1531Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi157 – 1571Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi190 – 1901Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi193 – 1931Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi196 – 1961Iron-sulfur 4 (4Fe-4S)By similarity
    Metal bindingi200 – 2001Iron-sulfur 3 (4Fe-4S)By similarity
    Metal bindingi264 – 2641Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi267 – 2671Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi271 – 2711Iron-sulfur 5 (4Fe-4S)By similarity
    Metal bindingi299 – 2991Iron-sulfur 5 (4Fe-4S)By similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
    2. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    3. electron carrier activity Source: InterPro
    4. formate dehydrogenase (NAD+) activity Source: UniProtKB-EC
    5. molybdenum ion binding Source: InterPro

    GO - Biological processi

    1. formate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-2260-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative formate dehydrogenase SAB2186c (EC:1.2.1.2)
    Gene namesi
    Ordered Locus Names:SAB2186c
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 984984Putative formate dehydrogenase SAB2186cPRO_0000304128Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273036.SAB2186c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YYT1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 79772Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini138 – 165284Fe-4S ferredoxin-type 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini181 – 211314Fe-4S ferredoxin-type 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini257 – 313574Fe-4S Mo/W bis-MGD-typePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni252 – 984733Formate dehydrogenaseAdd
    BLAST

    Sequence similaritiesi

    In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 2 4Fe-4S ferredoxin-type domains.PROSITE-ProRule annotation
    Contains 1 4Fe-4S Mo/W bis-MGD-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG3383.
    HOGENOMiHOG000031440.
    KOiK00123.
    OMAiFQGNDVA.
    OrthoDBiEOG6CVV7G.

    Family and domain databases

    InterProiIPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view]
    PfamiPF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036643. FDH_alpha. 1 hit.
    SMARTiSM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsiTIGR01591. Fdh-alpha. 1 hit.
    PROSITEiPS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YYT1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQEHLVVTLD GKDYLVEPGT NLLEFIKSQD TFVPSICYNE SMGPIQTCDT    50
    CTVEIDGKIE RSCSTVIDRP MTVNTVNNDV KDAQKEALDR ILEKHMLYCT 100
    VCDYNNGDCE IHNTMDAWGL QHQTYEYKEK PYEKDYGPFY RYDPNQCILC 150
    GRCVEACQDI EVNETIRIDW DREHPRVIWD NDVPINESSC VSCGQCATVC 200
    PCNAMMEVNM EGNAGYMTDT EPGSLAAMVD LTKKAEPGYG PLFAISDSEA 250
    EMRKERIKKT KTVCTYCGVG CSFEVWTKDR EILKVQPSHD SPANKIATCV 300
    KGKFSWGHIN SDQRLTKPLV RKNGEFHEVE WDEALNVIAD NFTSIKEKYG 350
    PDALSFISSS KATNEESYLM QKLARQVIGT NNVDNCSRYC QAPATKGLFR 400
    TVGHGGDSGS IEDLEKAAMS VLIGTNTAEA HPVIASRMKR AQKLFGQKIH 450
    VFDIRKHEMA ERADRFYQPK PGTDLAWLSA VTKYIIDHDL HDKAFIEEWV 500
    EDFDEYYKSL ETFTMAFAEE ATGIPEAELI KFAEECAKAE SVVICWAMGI 550
    TQQDIGSDSS TAISNLLLVT GNYRRPSTGA YPLRGHNNVQ GCSDMGSMPD 600
    KITGYQSIEA DDIRAKFEKE YGVKLNPKVG KDNHEMVEGV HDGEIHSLYL 650
    YGEDTGIVDS NINFVQAAFE NLDFMVVQDE FLTFTATFAD VVLPASPSLE 700
    KDGTFTNTER RIQRLYQALK PLGESKPDWK IFQAIANKLG FDWNYKHPSE 750
    IMDEIARLTP LYAGVSYERL EGFNSLQWPV HPDGTDEPIL YLEGFNFDNG 800
    KAKLFPLSFD NYFKQDEVYD IHVNNGRLLE HFHEGNMTYQ TPMIKYKVPR 850
    AFVEISPELA EDRGIHEGAE VKLISETGEA VLQVHVTDRV KGKEIYIPLN 900
    NDAMENGDLG AINLLTNSDV DQYTDTPSYK RTSCRLEVIA KRGKSPLNPN 950
    NFRVNKKRHP QYSVQVQKKW ERPDYVFPGN QVDK 984
    Length:984
    Mass (Da):111,309
    Last modified:December 20, 2005 - v1
    Checksum:iD9148E8BB9B4DA02
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81875.1.
    RefSeqiWP_001155290.1. NC_007622.1.
    YP_417643.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI81875; CAI81875; SAB2186c.
    GeneIDi3793615.
    KEGGisab:SAB2186c.
    PATRICi19525415. VBIStaAur92441_2303.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81875.1 .
    RefSeqi WP_001155290.1. NC_007622.1.
    YP_417643.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YYT1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB2186c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI81875 ; CAI81875 ; SAB2186c .
    GeneIDi 3793615.
    KEGGi sab:SAB2186c.
    PATRICi 19525415. VBIStaAur92441_2303.

    Phylogenomic databases

    eggNOGi COG3383.
    HOGENOMi HOG000031440.
    KOi K00123.
    OMAi FQGNDVA.
    OrthoDBi EOG6CVV7G.

    Enzyme and pathway databases

    BioCyci SAUR273036:GJVS-2260-MONOMER.

    Family and domain databases

    InterProi IPR001041. 2Fe-2S_ferredoxin-type.
    IPR001450. 4Fe4S-bd_dom.
    IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR009010. Asp_de-COase-like_dom.
    IPR006478. Formate_DH_asu.
    IPR006657. MoPterin_dinucl-bd_dom.
    IPR006656. Mopterin_OxRdtase.
    IPR006963. Mopterin_OxRdtase_4Fe-4S_dom.
    IPR006655. Mopterin_OxRdtase_prok_CS.
    IPR027467. MopterinOxRdtase_cofactor_BS.
    IPR019574. NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd.
    [Graphical view ]
    Pfami PF12838. Fer4_7. 1 hit.
    PF04879. Molybdop_Fe4S4. 1 hit.
    PF00384. Molybdopterin. 1 hit.
    PF01568. Molydop_binding. 1 hit.
    PF10588. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036643. FDH_alpha. 1 hit.
    SMARTi SM00926. Molybdop_Fe4S4. 1 hit.
    SM00929. NADH-G_4Fe-4S_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50692. SSF50692. 1 hit.
    SSF54292. SSF54292. 1 hit.
    TIGRFAMsi TIGR01591. Fdh-alpha. 1 hit.
    PROSITEi PS51085. 2FE2S_FER_2. 1 hit.
    PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    PS51669. 4FE4S_MOW_BIS_MGD. 1 hit.
    PS00551. MOLYBDOPTERIN_PROK_1. 1 hit.
    PS00932. MOLYBDOPTERIN_PROK_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiFDHL_STAAB
    AccessioniPrimary (citable) accession number: Q2YYT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3