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Protein

Demethylmenaquinone methyltransferase

Gene

menG

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).UniRule annotation

Catalytic activityi

A demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + S-adenosyl-L-homocysteine.UniRule annotation

Pathwayi: menaquinone biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Demethylmenaquinone methyltransferase (menG)
This subpathway is part of the pathway menaquinone biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes menaquinol from 1,4-dihydroxy-2-naphthoate, the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei60 – 601S-adenosyl-L-methionineUniRule annotation
Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Menaquinone biosynthesis

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-1355-MONOMER.
UniPathwayiUPA00079; UER00169.

Names & Taxonomyi

Protein namesi
Recommended name:
Demethylmenaquinone methyltransferaseUniRule annotation (EC:2.1.1.163UniRule annotation)
Gene namesi
Name:menGUniRule annotation
Ordered Locus Names:SAB1333c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 241241Demethylmenaquinone methyltransferasePRO_1000056309Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2YY85.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni106 – 1072S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000249463.
KOiK03183.
OMAiGGLHRAW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YY85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADNKANKEQ VHRVFQNISK KYDRLNNIIS FEQHKVWRKR VMKDMGVRKG
60 70 80 90 100
TKALDVCCGT GDWTIALSKA VGPTGEVTGI DFSENMLEVG KEKTASMENV
110 120 130 140 150
KLVHGDAMEL PFGDNSFDYV TIGFGLRNVP DYLVALKEMN RVLKPGGMVV
160 170 180 190 200
CLETSQPTLP AFKQMYALYF KFVMPIFGKL FAKSKEEYEW LQQSTFNFPG
210 220 230 240
KEELKRMFEE AGFINVRVRS FTGGVAAMHL GYKEKDNTKG D
Length:241
Mass (Da):27,323
Last modified:December 20, 2005 - v1
Checksum:i89BE102AA55B0E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81022.1.
RefSeqiWP_000774687.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81022; CAI81022; SAB1333c.
KEGGisab:SAB1333c.
PATRICi19523547. VBIStaAur92441_1422.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81022.1.
RefSeqiWP_000774687.1. NC_007622.1.

3D structure databases

ProteinModelPortaliQ2YY85.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI81022; CAI81022; SAB1333c.
KEGGisab:SAB1333c.
PATRICi19523547. VBIStaAur92441_1422.

Phylogenomic databases

HOGENOMiHOG000249463.
KOiK03183.
OMAiGGLHRAW.

Enzyme and pathway databases

UniPathwayiUPA00079; UER00169.
BioCyciSAUR273036:GJVS-1355-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01813. MenG_UbiE_methyltr. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
IPR004033. UbiE/COQ5_MeTrFase.
IPR023576. UbiE/COQ5_MeTrFase_CS.
[Graphical view]
PfamiPF01209. Ubie_methyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR01934. MenG_MenH_UbiE. 1 hit.
PROSITEiPS51608. SAM_MT_UBIE. 1 hit.
PS01183. UBIE_1. 1 hit.
PS01184. UBIE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMENG_STAAB
AccessioniPrimary (citable) accession number: Q2YY85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.