Q2YY66 (DHA1_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase 1
EC=1.4.1.1

Gene names

Name:	ald1
Ordered Locus Names:	SAB1304c

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer By similarity.
Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH.
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1.
Sequence similarities	Belongs to the AlaDH/PNT family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Alanine dehydrogenase 1		PRO_0000287318
Regions
	Nucleotide binding	170 – 200	31	NAD By similarity
Sites
	Active site	94	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2YY66 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 91FD28D3AECA3130	FASTA	372	40,145
	10 20 30 40 50 60 MLVAVVKELK QGEGRVACTP ENVRKLTAAG HKVIVEKNAG IGSGFSNDMY EKEGAKIVTH 70 80 90 100 110 120 EQAWEADLVI KVKEPHESEY QYFKKNQIIW GFLHLASSKE IVEKMQGVGV IAISGETIIK 130 140 150 160 170 180 NGKAELLAPM SAIAGQRSAI MGAYYSEAQH GGQGTLVTGV HENVDIPGST YVIFGGGVAA 190 200 210 220 230 240 TNAANVALGL NAKVIIIELN DDRIKYLEDM YAEKDVTVVK STPENLAEQI KKADVFISTI 250 260 270 280 290 300 LIPGAKPPKL VTREMVKSMK KGSVLIDIAI DQGGTIETIR PTTISDPVYE EEGVIHYGVP 310 320 330 340 350 360 NQPGAVPRTS TMALAQGNID YILEICDKGL EQAIKDNEAL SAGVNIYQGQ ETNQGLATSH 370 DLDYKEILNV IE

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed: 17971880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI80993.1.
RefSeq	YP_416780.1. NC_007622.1.
3D structure databases
ProteinModelPortal	Q2YY66.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YY66.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000012360; EBSTAP00000012017; EBSTAG00000012359.
GeneID	3794895.
GenomeReviews	Gene locus SAB1304c in contig AJ938182_GR.
KEGG	sab:SAB1304c.
NMPDR	fig|273036.3.peg.969.
PATRIC	19523485. VBIStaAur92441_1391.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0686.
GeneTree	EBGT00050000024386.
HOGENOM	HBG289735.
OMA	GAYYLEA.
PhylomeDB	Q2YY66.
ProtClustDB	CLSK885351.
Enzyme and pathway databases
BioCyc	SAUR273036:SAB1304C-MONOMER.
Family and domain databases
InterPro	IPR008143. Ala_DH/PNT_CS2. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view]
KO	K00259.
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
PROSITE	PS00836. ALADH_PNT_1. False negative. PS00837. ALADH_PNT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHA1_STAAB

Accession

Primary (citable) accession number: Q2YY66

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program