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Q2YXV4

- TYRA_STAAB

UniProt

Q2YXV4 - TYRA_STAAB

Protein

Prephenate dehydrogenase

Gene

tyrA

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi3 – 3331NADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. amino acid binding Source: InterPro
    2. prephenate dehydrogenase (NADP+) activity Source: InterPro
    3. prephenate dehydrogenase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tyrosine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tyrosine biosynthesis

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-1242-MONOMER.
    UniPathwayiUPA00122; UER00961.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prephenate dehydrogenase (EC:1.3.1.12)
    Short name:
    PDH
    Gene namesi
    Name:tyrA
    Ordered Locus Names:SAB1220c
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 363363Prephenate dehydrogenasePRO_0000282654Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273036.SAB1220c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YXV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 291290Prephenate/arogenate dehydrogenasePROSITE-ProRule annotationAdd
    BLAST
    Domaini296 – 36368ACTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ACT domain.PROSITE-ProRule annotation
    Contains 1 prephenate/arogenate dehydrogenase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0287.
    HOGENOMiHOG000043494.
    KOiK04517.
    OMAiHAMAGTH.
    OrthoDBiEOG6B8XMB.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view]
    PfamiPF02153. PDH. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    PROSITEiPS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YXV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVLFVGLG LIGGSLASNI KYHNPNTNII AYDADTSQLD KAKSIGIINE    50
    KCLNYSEAIK KADVIIYATP VAITNKYLSE LIDMPTKPGV IVSDTGSTKA 100
    MIQQHECSLL KHNIHLVSGH PMAGSHKSGV LNAKKHLFEN AYYILVYNEP 150
    RNEQAANTLK ELLSPTLAKF IVTTAEEHDY VTSVVSHLPH IVASSLVHVS 200
    QKNGQEHHLV NKLAAGGFRD ITRIASSNVQ MWKDITLSNK TYILEMIGQL 250
    KSQFQDLEKL IESNDSEKLS SFFAEAKSYR DALPAKQLGG LNTAYDLYVD 300
    IPDESGMISK VTYILSLHNI SISNLRILEV REDIYGALKI SFKNPTDRER 350
    GMQALSDFDC YIQ 363
    Length:363
    Mass (Da):40,244
    Last modified:December 20, 2005 - v1
    Checksum:i3406561C5A7B71A9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI80909.1.
    RefSeqiWP_000214272.1. NC_007622.1.
    YP_416697.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI80909; CAI80909; SAB1220c.
    GeneIDi3793070.
    KEGGisab:SAB1220c.
    PATRICi19523311. VBIStaAur92441_1304.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI80909.1 .
    RefSeqi WP_000214272.1. NC_007622.1.
    YP_416697.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YXV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB1220c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI80909 ; CAI80909 ; SAB1220c .
    GeneIDi 3793070.
    KEGGi sab:SAB1220c.
    PATRICi 19523311. VBIStaAur92441_1304.

    Phylogenomic databases

    eggNOGi COG0287.
    HOGENOMi HOG000043494.
    KOi K04517.
    OMAi HAMAGTH.
    OrthoDBi EOG6B8XMB.

    Enzyme and pathway databases

    UniPathwayi UPA00122 ; UER00961 .
    BioCyci SAUR273036:GJVS-1242-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR002912. ACT_dom.
    IPR016040. NAD(P)-bd_dom.
    IPR003099. Prephen_DH.
    [Graphical view ]
    Pfami PF02153. PDH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    PROSITEi PS51671. ACT. 1 hit.
    PS51176. PDH_ADH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiTYRA_STAAB
    AccessioniPrimary (citable) accession number: Q2YXV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3