Q2YXM0 (Q2YXM0_STAAB) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha RuleBase RU000699
EC=6.2.1.5 RuleBase RU000699

Gene names

Ordered Locus Names:

SAB1110

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP] EMBL CAI80799.1

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. RuleBase RU000699
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity. RuleBase RU000699
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family. RuleBase RU000677

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU000699 Nucleotide-binding
Molecular function	Ligase RuleBase RU000677 EMBL CAI80799.1
PTM	Phosphoprotein RuleBase RU000677
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	247	1	Tele-phosphohistidine intermediate By similarity PIRSR PIRSR001553-1

Sequences

	Sequence		Length	Mass (Da)
	Q2YXM0 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: C05AFD1B8DCC69E4	FASTA	302	31,542
	10 20 30 40 50 60 MSVFIDKNTK VMVQGITGST ALFHTKQMLD YGTKIVAGVT PGKGGQVVEG VPVFNTVEEA 70 80 90 100 110 120 KNETGATVSV IYVPAPFAAD SILEAADADL DMVICITEHI PVLDMVKVKR YLQGRKTRLV 130 140 150 160 170 180 GPNCPGVITA DECKIGIMPG YIHKKGHVGV VSRSGTLTYE AVHQLTEEGI GQTTAVGIGG 190 200 210 220 230 240 DPVNGTNFID VLKAFNEDDE TKAVVMIGEI GGTAEEEAAE WIKANMTKPV VGFIGGQTAP 250 260 270 280 290 300 PGKRMGHAGA IISGGKGTAE EKIKTLNSCG VKTAATPSEI GSTLIEAAKE AGIYESLLTV NK

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI80799.1.
RefSeq	YP_416590.1. NC_007622.1.
3D structure databases
ProteinModelPortal	Q2YXM0.
SMR	Q2YXM0. Positions 2-284.
ModBase	Search...
Protein-protein interaction databases
STRING	273036.SAB1110.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI80799; CAI80799; SAB1110.
GeneID	3795071.
KEGG	sab:SAB1110.
PATRIC	19523067. VBIStaAur92441_1182.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0074.
HOGENOM	HOG000239685.
KO	K01902.
OMA	KGRKKPM.
ProtClustDB	PRK05678.
Enzyme and pathway databases
BioCyc	SAUR273036:GJVS-1132-MONOMER.
Family and domain databases
Gene3D	3.40.50.261. 1 hit. 3.40.50.720. 1 hit.
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Pfam	PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001553. SucCS_alpha. 1 hit.
PRINTS	PR01798. SCOASYNTHASE.
SMART	SM00881. CoA_binding. 1 hit. [Graphical view]
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01019. sucCoAalpha. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q2YXM0_STAAB

Accession

Primary (citable) accession number: Q2YXM0

Entry history

Integrated into UniProtKB/TrEMBL:	December 20, 2005
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)