Q2YWJ9 (AROD_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type I DHQase

Gene names

Name:	aroD
Ordered Locus Names:	SAB0760

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214
Subunit structure	Homodimer By similarity. HAMAP MF_00214
Sequence similarities	Belongs to the type-I 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	3-dehydroquinate dehydratase HAMAP MF_00214		PRO_1000043188
Sites
	Active site	133	1	Proton acceptor By similarity
	Active site	160	1	Schiff-base intermediate with substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YWJ9 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: E519F458CF021BA8	FASTA	238	27,000
	10 20 30 40 50 60 MTHVEVVATI APQLYIEETL IQKINHRIDA IDVLELRIDQ IENVTVNQVA EMITKLKVMQ 70 80 90 100 110 120 DSFKLLVTYR TKLQGGYGQF TNDLYLNLIS DLANINGIDM IDIEWQADID IEKHQRIITH 130 140 150 160 170 180 LQQYNKEVVI SHHNFESTPP LDELQFIFFK MQKFNPEYVK LAVMPHNKND VLNLLQAMST 190 200 210 220 230 FSDTMDCKVV GISMSKLGLI SRTAQGVFGG ALTYGCIGEP QAPGQIDVTD LKAQVTLY

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed: 17971880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI80448.1.
RefSeq	YP_416253.1. NC_007622.1.
3D structure databases
ProteinModelPortal	Q2YWJ9.
SMR	Q2YWJ9. Positions 3-238.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YWJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000012241; EBSTAP00000011898; EBSTAG00000012240.
GeneID	3793548.
GenomeReviews	Gene locus SAB0760 in contig AJ938182_GR.
KEGG	sab:SAB0760.
NMPDR	fig|273036.3.peg.863.
PATRIC	19522325. VBIStaAur92441_0813.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0710.
GeneTree	EBGT00050000025297.
HOGENOM	HBG732926.
OMA	IAKIAVM.
PhylomeDB	Q2YWJ9.
ProtClustDB	PRK13575.
Enzyme and pathway databases
BioCyc	SAUR273036:SAB0760-MONOMER.
Family and domain databases
HAMAP	MF_00214. AroD. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K03785.
Pfam	PF01487. DHquinase_I. 1 hit. [Graphical view]
TIGRFAMs	TIGR01093. AroD. 1 hit.
PROSITE	PS01028. DEHYDROQUINASE_I. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROD_STAAB

Accession

Primary (citable) accession number: Q2YWJ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 20, 2005
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program