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Q2YWA3 (COPA_STAAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Copper-exporting P-type ATPase A
EC=3.6.3.n1
Gene names
Name:copA
Ordered Locus Names:SAB2431
OrganismStaphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]
Taxonomic identifier273036 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length802 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in copper export By similarity.

Catalytic activity

ATP + H2O + Cu+(In) = ADP + phosphate + Cu+(Out).

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily. [View classification]

Contains 2 HMA domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 802802Copper-exporting P-type ATPase A
PRO_0000350583

Regions

Transmembrane161 – 18121Helical; Potential
Transmembrane192 – 21221Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane256 – 27621Helical; Potential
Transmembrane411 – 43121Helical; Potential
Transmembrane438 – 45821Helical; Potential
Transmembrane748 – 76720Helical; Potential
Transmembrane771 – 79020Helical; Potential
Domain6 – 7166HMA 1
Domain73 – 13967HMA 2

Sites

Active site49514-aspartylphosphate intermediate By similarity
Metal binding161Copper 1 By similarity
Metal binding191Copper 1 By similarity
Metal binding831Copper 2 By similarity
Metal binding861Copper 2 By similarity
Metal binding6901Magnesium By similarity
Metal binding6941Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YWA3 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 3950492E6BC73E6E

FASTA80286,716
        10         20         30         40         50         60 
MANTKKTTLD ITGMTCAACS NRIEKKLNKL DDVNAQVNLT TEKATVEYNP DQHDVQEFIN 

        70         80         90        100        110        120 
TIQHLGYGVA VETVELDITG MTCAACSSRI EKVLNKMDGV QNATVNLTTE QAKVDYYPEE 

       130        140        150        160        170        180 
TDADKLVTRI QKLGYDASIK DNNKDQTSRK AEALQHKLIK LIISAVLSLP LLMLMFVHLF 

       190        200        210        220        230        240 
NMHIPALFTN PWFQFILATP VQFIIGWQFY VGAYKNLRNG GANMDVLVAV GTSAAYFYSI 

       250        260        270        280        290        300 
YEMIRWLNGS TTQPHLYFET SAVLITLILF GKYLEARAKS QTTNALGELL SLQAKEARIL 

       310        320        330        340        350        360 
KDGNELMIPL NEVHVGDTLI VKPGEKIPVD GKIIKGMTAI DESMLTGESI PVEKNVDDTV 

       370        380        390        400        410        420 
IGSTMNKNGT ITMTATKVGG DTALANIIKV VEEAQSSKAP IQRLADIISG YFVPIVVGIA 

       430        440        450        460        470        480 
LLTFIVWITL VTPGTFEPAL VASISVLVIA CPCALGLATP TSIMVGTGRA AENGILFKGG 

       490        500        510        520        530        540 
EFVERTHQID TIVLDKTGTI TNGRPVVTDY HGDDQTLQLL ATAEKDSEHP LAEAIVNYAK 

       550        560        570        580        590        600 
EKQLTLTETT TFKAVPGHGI EATIDHHHIL VGNRKLMADN DISLPKHISD DLTHYERDGK 

       610        620        630        640        650        660 
TAMLIAVNYS LTGIIAVADT LKNHAKDAIK QLHDMGIEVA MLTGDNKNTA QAIAKQVGID 

       670        680        690        700        710        720 
TVIADILPEE KAAQIAKLQQ QGKKVAMVGD GVNDAPALVK ADIGIAIGTG TEVAIEAAGI 

       730        740        750        760        770        780 
TILGGDLMLI PKAIYASKAT IRNIRQNLFW AFGYNIAGIP IAALGLLAPW VAGAAMALSS 

       790        800 
VSVVTNALRL KKMRLEPRRK DA

« Hide

References

[1]"Molecular correlates of host specialization in Staphylococcus aureus."
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ938182 Genomic DNA. Translation: CAI82119.1.
RefSeqYP_417880.1. NC_007622.1.

3D structure databases

HSSPHSSP built from PDB template 2EW9 based on UniProtKB P35670.
ProteinModelPortalQ2YWA3.
ModBaseSearch...

Protein-protein interaction databases

STRING273036.SAB2431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI82119; CAI82119; SAB2431.
GeneID3794843.
KEGGsab:SAB2431.
PATRIC19525927. VBIStaAur92441_2559.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2217.
HOGENOMHOG000250397.
KOK01533.
OMAIHKLQQS.
ProtClustDBCLSK886068.

Enzyme and pathway databases

BioCycSAUR273036:GJVS-2504-MONOMER.

Family and domain databases

Gene3D2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR027256. Cation_transp_P-typ_ATPase_IB.
IPR001757. Cation_transp_P_typ_ATPase.
IPR027183. Cu-transptr_ATPase.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HeavyMe-assoc_HMA.
IPR006122. HMA_Cu_ion-bd.
[Graphical view]
PANTHERPTHR24093. PTHR24093. 1 hit.
PTHR24093:SF50. PTHR24093:SF50. 1 hit.
PfamPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF56784. HAD-like_dom. 1 hit.
SSF55008. HeavyMe_transpt. 2 hits.
TIGRFAMsTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOPA_STAAB
AccessionPrimary (citable) accession number: Q2YWA3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: December 20, 2005
Last modified: May 1, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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