Q2YW63 (GTAB_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UTP--glucose-1-phosphate uridylyltransferase
EC=2.7.7.9

Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name=UDPGP
Uridine diphosphoglucose pyrophosphorylase

Gene names

Name:	gtaB
Ordered Locus Names:	SAB2374c

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) By similarity.
Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Glycolipid metabolism; diglucosyl-diacylglycerol biosynthesis.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro enterobacterial common antigen biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	UTP--glucose-1-phosphate uridylyltransferase		PRO_0000308303

Sequences

	Sequence		Length	Mass (Da)
	Q2YW63 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 90EC897952735406	FASTA	288	32,537
	10 20 30 40 50 60 MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI EDIIIVTGRH 70 80 90 100 110 120 KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF YVRQKEQKGL GHAISSARQF 130 140 150 160 170 180 IGNEPFVVLL GDDIVESEVP AVKQLIDVYE ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG 190 200 210 220 230 240 RQYEVKKFVE KPAQGTAPSN LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND 250 260 270 280 NQVYAYDFEG ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKELGL

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI82062.1.
RefSeq	YP_417824.1. NC_007622.1.
3D structure databases
ProteinModelPortal	Q2YW63.
ModBase	Search...
Protein-protein interaction databases
STRING	273036.SAB2374c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI82062; CAI82062; SAB2374c.
GeneID	3794236.
KEGG	sab:SAB2374c.
PATRIC	19525805. VBIStaAur92441_2498.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1210.
HOGENOM	HOG000283477.
KO	K00963.
OMA	DALQHMI.
ProtClustDB	CLSK886023.
Enzyme and pathway databases
BioCyc	SAUR273036:GJVS-2447-MONOMER.
UniPathway	UPA00894.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GTAB_STAAB

Accession

Primary (citable) accession number: Q2YW63

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 20, 2005
Last modified:	May 1, 2013
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program