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Q2YW63

- GTAB_STAAB

UniProt

Q2YW63 - GTAB_STAAB

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Protein

UTP--glucose-1-phosphate uridylyltransferase

Gene

gtaB

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of UDP-glucose from glucose-1-phosphate and UTP. This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA) (By similarity).By similarity

Catalytic activityi

UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.

Pathwayi

GO - Molecular functioni

  1. UTP:glucose-1-phosphate uridylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. enterobacterial common antigen biosynthetic process Source: UniProtKB-UniPathway
  2. UDP-glucose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-2447-MONOMER.
UniPathwayiUPA00894.

Names & Taxonomyi

Protein namesi
Recommended name:
UTP--glucose-1-phosphate uridylyltransferase (EC:2.7.7.9)
Alternative name(s):
Alpha-D-glucosyl-1-phosphate uridylyltransferase
UDP-glucose pyrophosphorylase
Short name:
UDPGP
Uridine diphosphoglucose pyrophosphorylase
Gene namesi
Name:gtaB
Ordered Locus Names:SAB2374c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001927: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288UTP--glucose-1-phosphate uridylyltransferasePRO_0000308303Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273036.SAB2374c.

Structurei

3D structure databases

ProteinModelPortaliQ2YW63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UDPGP type 2 family.Curated

Phylogenomic databases

eggNOGiCOG1210.
HOGENOMiHOG000283477.
KOiK00963.
OMAiKLIDECS.
OrthoDBiEOG6Z9B3V.

Family and domain databases

Gene3Di3.90.550.10. 1 hit.
InterProiIPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00483. NTP_transferase. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
TIGRFAMsiTIGR01099. galU. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YW63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKKIKKAIIP AAGLGTRFLP ATKAMPKEML PILDKPTIQY IVEEAARAGI
60 70 80 90 100
EDIIIVTGRH KRAIEDHFDS QKELEMVLKE KGKSELLEKV QYSTELANIF
110 120 130 140 150
YVRQKEQKGL GHAISSARQF IGNEPFVVLL GDDIVESEVP AVKQLIDVYE
160 170 180 190 200
ETGHSVIGVQ EVPEADTHRY GIIDPLTKNG RQYEVKKFVE KPAQGTAPSN
210 220 230 240 250
LAIMGRYVLT PEIFDYLKTQ KEGAGNEIQL TDAIERMNND NQVYAYDFEG
260 270 280
ERYDVGEKLG FVKTTIEYAL KDDSMREELT RFIKELGL
Length:288
Mass (Da):32,537
Last modified:December 20, 2005 - v1
Checksum:i90EC897952735406
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI82062.1.
RefSeqiWP_000721339.1. NC_007622.1.
YP_417824.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI82062; CAI82062; SAB2374c.
GeneIDi3794236.
KEGGisab:SAB2374c.
PATRICi19525805. VBIStaAur92441_2498.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI82062.1 .
RefSeqi WP_000721339.1. NC_007622.1.
YP_417824.1. NC_007622.1.

3D structure databases

ProteinModelPortali Q2YW63.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273036.SAB2374c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI82062 ; CAI82062 ; SAB2374c .
GeneIDi 3794236.
KEGGi sab:SAB2374c.
PATRICi 19525805. VBIStaAur92441_2498.

Phylogenomic databases

eggNOGi COG1210.
HOGENOMi HOG000283477.
KOi K00963.
OMAi KLIDECS.
OrthoDBi EOG6Z9B3V.

Enzyme and pathway databases

UniPathwayi UPA00894 .
BioCyci SAUR273036:GJVS-2447-MONOMER.

Family and domain databases

Gene3Di 3.90.550.10. 1 hit.
InterProi IPR005771. GalU_uridylyltTrfase_bac/arc.
IPR005835. NTP_transferase.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
Pfami PF00483. NTP_transferase. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
TIGRFAMsi TIGR01099. galU. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiGTAB_STAAB
AccessioniPrimary (citable) accession number: Q2YW63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 20, 2005
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3