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Q2YVY8

- BIOW_STAAB

UniProt

Q2YVY8 - BIOW_STAAB

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Protein
6-carboxyhexanoate--CoA ligase
Gene
bioW, SAB2304c
Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP By similarity.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 6-carboxyhexanoate-CoA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-2378-MONOMER.
UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligase (EC:6.2.1.14)
Alternative name(s):
Pimeloyl-CoA synthase
Gene namesi
Name:bioW
Ordered Locus Names:SAB2304c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001927: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2302306-carboxyhexanoate--CoA ligaseUniRule annotation
PRO_1000044698Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi273036.SAB2304c.

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.

Phylogenomic databases

eggNOGiCOG1424.
HOGENOMiHOG000253976.
KOiK01906.
OMAiCWSDDPD.
OrthoDBiEOG6VB6WG.

Family and domain databases

HAMAPiMF_00668. BioW.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q2YVY8-1 [UniParc]FASTAAdd to Basket

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MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN    50
IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE 100
TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDMNNKGD LNERVTDALA 150
IASCINAHPY VKGELCVSDD LTYTTGYFAS AKIGYHRLFD IKPVNTRYGG 200
RIIFVDDRID LNHYISFLES TPKQVVYETV 230
Length:230
Mass (Da):26,179
Last modified:December 20, 2005 - v1
Checksum:i1F9C0494EEA669B6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ938182 Genomic DNA. Translation: CAI81993.1.
RefSeqiYP_417760.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81993; CAI81993; SAB2304c.
GeneIDi3794057.
KEGGisab:SAB2304c.
PATRICi19525657. VBIStaAur92441_2424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ938182 Genomic DNA. Translation: CAI81993.1 .
RefSeqi YP_417760.1. NC_007622.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273036.SAB2304c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI81993 ; CAI81993 ; SAB2304c .
GeneIDi 3794057.
KEGGi sab:SAB2304c.
PATRICi 19525657. VBIStaAur92441_2424.

Phylogenomic databases

eggNOGi COG1424.
HOGENOMi HOG000253976.
KOi K01906.
OMAi CWSDDPD.
OrthoDBi EOG6VB6WG.

Enzyme and pathway databases

UniPathwayi UPA00999 ; UER00351 .
BioCyci SAUR273036:GJVS-2378-MONOMER.

Family and domain databases

HAMAPi MF_00668. BioW.
InterProi IPR005499. BioW.
[Graphical view ]
Pfami PF03744. BioW. 1 hit.
[Graphical view ]
ProDomi PD017229. BioW. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiBIOW_STAAB
AccessioniPrimary (citable) accession number: Q2YVY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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