Q2YVY8 (BIOW_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
6-carboxyhexanoate--CoA ligase
EC=6.2.1.14

Alternative name(s):
Pimeloyl-CoA synthase

Gene names

Name:	bioW
Ordered Locus Names:	SAB2304c

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP By similarity. HAMAP-Rule MF_00668
Catalytic activity	ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. HAMAP-Rule MF_00668
Cofactor	Magnesium By similarity. HAMAP-Rule MF_00668
Pathway	Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. HAMAP-Rule MF_00668
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00668
Sequence similarities	Belongs to the BioW family.

Ontologies

Keywords
Biological process	Biotin biosynthesis
Ligand	ATP-binding Magnesium Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	biotin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	6-carboxyhexanoate-CoA ligase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	6-carboxyhexanoate--CoA ligase HAMAP-Rule MF_00668		PRO_1000044698

Sequences

	Sequence		Length	Mass (Da)
	Q2YVY8 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 1F9C0494EEA669B6	FASTA	230	26,179
	10 20 30 40 50 60 MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI 70 80 90 100 110 120 QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF 130 140 150 160 170 180 GQRGIRATHF SFEDMNNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAS 190 200 210 220 230 AKIGYHRLFD IKPVNTRYGG RIIFVDDRID LNHYISFLES TPKQVVYETV

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI81993.1.
RefSeq	YP_417760.1. NC_007622.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	273036.SAB2304c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI81993; CAI81993; SAB2304c.
GeneID	3794057.
KEGG	sab:SAB2304c.
PATRIC	19525657. VBIStaAur92441_2424.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1424.
HOGENOM	HOG000253976.
KO	K01906.
OMA	TTGYVAT.
ProtClustDB	PRK01322.
Enzyme and pathway databases
BioCyc	SAUR273036:GJVS-2378-MONOMER.
UniPathway	UPA00999; UER00351.
Family and domain databases
HAMAP	MF_00668. BioW.
InterPro	IPR005499. BioW. [Graphical view]
Pfam	PF03744. BioW. 1 hit. [Graphical view]
ProDom	PD017229. BioW. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...

Entry information

Entry name

BIOW_STAAB

Accession

Primary (citable) accession number: Q2YVY8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	December 20, 2005
Last modified:	May 29, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program