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Q2YVY8

- BIOW_STAAB

UniProt

Q2YVY8 - BIOW_STAAB

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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 6-carboxyhexanoate-CoA ligase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. biotin biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Biotin biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-2378-MONOMER.
UniPathwayiUPA00999; UER00351.

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:SAB2304c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001927: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2302306-carboxyhexanoate--CoA ligasePRO_1000044698Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi273036.SAB2304c.

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1424.
HOGENOMiHOG000253976.
KOiK01906.
OMAiCWSDDPD.
OrthoDBiEOG6VB6WG.

Family and domain databases

HAMAPiMF_00668. BioW.
InterProiIPR005499. BioW.
[Graphical view]
PfamiPF03744. BioW. 1 hit.
[Graphical view]
ProDomiPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q2YVY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN
60 70 80 90 100
IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE
110 120 130 140 150
TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDMNNKGD LNERVTDALA
160 170 180 190 200
IASCINAHPY VKGELCVSDD LTYTTGYFAS AKIGYHRLFD IKPVNTRYGG
210 220 230
RIIFVDDRID LNHYISFLES TPKQVVYETV
Length:230
Mass (Da):26,179
Last modified:December 20, 2005 - v1
Checksum:i1F9C0494EEA669B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81993.1.
RefSeqiWP_000286882.1. NC_007622.1.
YP_417760.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81993; CAI81993; SAB2304c.
GeneIDi3794057.
KEGGisab:SAB2304c.
PATRICi19525657. VBIStaAur92441_2424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81993.1 .
RefSeqi WP_000286882.1. NC_007622.1.
YP_417760.1. NC_007622.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273036.SAB2304c.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI81993 ; CAI81993 ; SAB2304c .
GeneIDi 3794057.
KEGGi sab:SAB2304c.
PATRICi 19525657. VBIStaAur92441_2424.

Phylogenomic databases

eggNOGi COG1424.
HOGENOMi HOG000253976.
KOi K01906.
OMAi CWSDDPD.
OrthoDBi EOG6VB6WG.

Enzyme and pathway databases

UniPathwayi UPA00999 ; UER00351 .
BioCyci SAUR273036:GJVS-2378-MONOMER.

Family and domain databases

HAMAPi MF_00668. BioW.
InterProi IPR005499. BioW.
[Graphical view ]
Pfami PF03744. BioW. 1 hit.
[Graphical view ]
ProDomi PD017229. BioW. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
ProtoNeti Search...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiBIOW_STAAB
AccessioniPrimary (citable) accession number: Q2YVY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3