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Q2YVY8

- BIOW_STAAB

UniProt

Q2YVY8 - BIOW_STAAB

Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

    Catalytic activityi

    ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 6-carboxyhexanoate-CoA ligase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. biotin biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Biotin biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-2378-MONOMER.
    UniPathwayiUPA00999; UER00351.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
    Alternative name(s):
    Pimeloyl-CoA synthaseUniRule annotation
    Gene namesi
    Name:bioWUniRule annotation
    Ordered Locus Names:SAB2304c
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2302306-carboxyhexanoate--CoA ligasePRO_1000044698Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi273036.SAB2304c.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BioW family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1424.
    HOGENOMiHOG000253976.
    KOiK01906.
    OMAiCWSDDPD.
    OrthoDBiEOG6VB6WG.

    Family and domain databases

    HAMAPiMF_00668. BioW.
    InterProiIPR005499. BioW.
    [Graphical view]
    PfamiPF03744. BioW. 1 hit.
    [Graphical view]
    ProDomiPD017229. BioW. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q2YVY8-1 [UniParc]FASTAAdd to Basket

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    MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN    50
    IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE 100
    TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDMNNKGD LNERVTDALA 150
    IASCINAHPY VKGELCVSDD LTYTTGYFAS AKIGYHRLFD IKPVNTRYGG 200
    RIIFVDDRID LNHYISFLES TPKQVVYETV 230
    Length:230
    Mass (Da):26,179
    Last modified:December 20, 2005 - v1
    Checksum:i1F9C0494EEA669B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81993.1.
    RefSeqiYP_417760.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI81993; CAI81993; SAB2304c.
    GeneIDi3794057.
    KEGGisab:SAB2304c.
    PATRICi19525657. VBIStaAur92441_2424.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81993.1 .
    RefSeqi YP_417760.1. NC_007622.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB2304c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI81993 ; CAI81993 ; SAB2304c .
    GeneIDi 3794057.
    KEGGi sab:SAB2304c.
    PATRICi 19525657. VBIStaAur92441_2424.

    Phylogenomic databases

    eggNOGi COG1424.
    HOGENOMi HOG000253976.
    KOi K01906.
    OMAi CWSDDPD.
    OrthoDBi EOG6VB6WG.

    Enzyme and pathway databases

    UniPathwayi UPA00999 ; UER00351 .
    BioCyci SAUR273036:GJVS-2378-MONOMER.

    Family and domain databases

    HAMAPi MF_00668. BioW.
    InterProi IPR005499. BioW.
    [Graphical view ]
    Pfami PF03744. BioW. 1 hit.
    [Graphical view ]
    ProDomi PD017229. BioW. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiBIOW_STAAB
    AccessioniPrimary (citable) accession number: Q2YVY8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3