Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2YVY8 (BIOW_STAAB) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
6-carboxyhexanoate--CoA ligase

EC=6.2.1.14
Alternative name(s):
Pimeloyl-CoA synthase
Gene names
Name:bioW
Ordered Locus Names:SAB2304c
OrganismStaphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]
Taxonomic identifier273036 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length230 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP By similarity. HAMAP-Rule MF_00668

Catalytic activity

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA. HAMAP-Rule MF_00668

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00668

Pathway

Metabolic intermediate metabolism; pimeloyl-CoA biosynthesis; pimeloyl-CoA from pimelate: step 1/1. HAMAP-Rule MF_00668

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00668

Sequence similarities

Belongs to the BioW family.

Ontologies

Keywords
   Biological processBiotin biosynthesis
   LigandATP-binding
Magnesium
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processbiotin biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_function6-carboxyhexanoate-CoA ligase activity

Inferred from electronic annotation. Source: UniProtKB-EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2302306-carboxyhexanoate--CoA ligase HAMAP-Rule MF_00668
PRO_1000044698

Sequences

Sequence LengthMass (Da)Tools
Q2YVY8 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 1F9C0494EEA669B6

FASTA23026,179
        10         20         30         40         50         60 
MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN IKIQKIMEPI 

        70         80         90        100        110        120 
QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE TVYTGAIILS AISGKRLDSF 

       130        140        150        160        170        180 
GQRGIRATHF SFEDMNNKGD LNERVTDALA IASCINAHPY VKGELCVSDD LTYTTGYFAS 

       190        200        210        220        230 
AKIGYHRLFD IKPVNTRYGG RIIFVDDRID LNHYISFLES TPKQVVYETV 

« Hide

References

[1]"Molecular correlates of host specialization in Staphylococcus aureus."
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ938182 Genomic DNA. Translation: CAI81993.1.
RefSeqYP_417760.1. NC_007622.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273036.SAB2304c.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI81993; CAI81993; SAB2304c.
GeneID3794057.
KEGGsab:SAB2304c.
PATRIC19525657. VBIStaAur92441_2424.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1424.
HOGENOMHOG000253976.
KOK01906.
OMACWSDDPD.
OrthoDBEOG6VB6WG.

Enzyme and pathway databases

BioCycSAUR273036:GJVS-2378-MONOMER.
UniPathwayUPA00999; UER00351.

Family and domain databases

HAMAPMF_00668. BioW.
InterProIPR005499. BioW.
[Graphical view]
PfamPF03744. BioW. 1 hit.
[Graphical view]
ProDomPD017229. BioW. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetSearch...

Entry information

Entry nameBIOW_STAAB
AccessionPrimary (citable) accession number: Q2YVY8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways