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Protein

6-carboxyhexanoate--CoA ligase

Gene

bioW

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.UniRule annotation

Catalytic activityi

ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: pimeloyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes pimeloyl-CoA from pimelate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 6-carboxyhexanoate--CoA ligase (bioW)
This subpathway is part of the pathway pimeloyl-CoA biosynthesis, which is itself part of Metabolic intermediate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pimeloyl-CoA from pimelate, the pathway pimeloyl-CoA biosynthesis and in Metabolic intermediate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processBiotin biosynthesis
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR273036:G1G1D-2557-MONOMER
UniPathwayiUPA00999; UER00351

Names & Taxonomyi

Protein namesi
Recommended name:
6-carboxyhexanoate--CoA ligaseUniRule annotation (EC:6.2.1.14UniRule annotation)
Alternative name(s):
Pimeloyl-CoA synthaseUniRule annotation
Gene namesi
Name:bioWUniRule annotation
Ordered Locus Names:SAB2304c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000446981 – 2306-carboxyhexanoate--CoA ligaseAdd BLAST230

Proteomic databases

PRIDEiQ2YVY8

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

SMRiQ2YVY8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BioW family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000253976
KOiK01906
OMAiLCWSDDP

Family and domain databases

HAMAPiMF_00668 BioW, 1 hit
InterProiView protein in InterPro
IPR005499 BioW
PfamiView protein in Pfam
PF03744 BioW, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD017229 BioW, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YVY8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSIKMRSSN QDVHISGAET ICEFDKIEQT VQRFYNKGFF HENGQPDFLN
60 70 80 90 100
IKIQKIMEPI QQIKALQIIE DDKANLQHLT QECGVTEQAL NQGMTYIKNE
110 120 130 140 150
TVYTGAIILS AISGKRLDSF GQRGIRATHF SFEDMNNKGD LNERVTDALA
160 170 180 190 200
IASCINAHPY VKGELCVSDD LTYTTGYFAS AKIGYHRLFD IKPVNTRYGG
210 220 230
RIIFVDDRID LNHYISFLES TPKQVVYETV
Length:230
Mass (Da):26,179
Last modified:December 20, 2005 - v1
Checksum:i1F9C0494EEA669B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81993.1
RefSeqiWP_000286882.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI81993; CAI81993; SAB2304c
KEGGisab:SAB2304c

Similar proteinsi

Entry informationi

Entry nameiBIOW_STAAB
AccessioniPrimary (citable) accession number: Q2YVY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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