Reviewed, UniProtKB/Swiss-Prot Q2YVT4 (SLE1_STAAB)

Names and origin

Protein names

Recommended name:
    N-acetylmuramoyl-L-alanine amidase sle1
    EC=3.5.1.28

Gene names

Name:	sle1
Synonyms:	aaa
Ordered Locus Names:	SAB0414

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Peptidoglycan hydrolase involved in the splitting of the septum during cell division By similarity.
Catalytic activity	Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
Subcellular location	Secreted By similarity. Cell surface By similarity.
Sequence similarities	Contains 3 LysM repeats. Contains 1 peptidase C51 domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell wall biogenesis/degradation Septation Virulence
Cellular component	Secreted
Domain	Repeat Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	barrier septum formation Inferred from electronic annotation. Source: UniProtKB-KW cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cell surface Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetylmuramoyl-L-alanine amidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 335	310	N-acetylmuramoyl-L-alanine amidase sle1		PRO_0000231621
Regions
	Repeat	29 – 71	43	LysM 1
	Repeat	93 – 135	43	LysM 2
	Repeat	160 – 202	43	LysM 3
	Domain	211 – 335	125	Peptidase C51

Sequences

	Sequence		Length	Mass (Da)
	Q2YVT4-1 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 4C132CC34205FFB3	FASTA	335	35,937
	10 20 30 40 50 60 MQKKVIAAII GTSAISAVAA TQANAATTHT VKPGESVWAI SNKYGISIAK LKSLNNLTSN 70 80 90 100 110 120 LIFPNQVLKV SGSSNSTSNS SRPSTNSGGG SYYTVQAGDS LSLIASKYGT TYQNIMRLNG 130 140 150 160 170 180 LNNFFIYPGQ KLKVSGTASS SNAASNSSRP STNSGGGSYY TVQAGDSLSL IASKYGTTYQ 190 200 210 220 230 240 KIMSLNGLNN FFIYPGQKLK VTGNATSSNS ASATTTNRGY NTPVFSHQNL YTWGQCTYHV 250 260 270 280 290 300 FNRRAEIGKG ISTYWWNANN WDNAAAADGY TIDNRPTVGS IAQTDVGYYG HVMFVERVNN 310 320 330 DGSILVSEMN YSAAPGILTY RTVPAYQVNN YRYIH

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed: 17971880] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ938182 Genomic DNA. Translation: CAI80102.1.
RefSeq	YP_415913.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q2YVT4.
Protein family/group databases
CAZy	CBM50. Carbohydrate-Binding Module Family 50.
Genome annotation databases
GeneID	3792711.
GenomeReviews	Gene locus SAB0414 in contig AJ938182_GR.
KEGG	sab:SAB0414.
NMPDR	fig|273036.3.peg.80.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2YVT4.
OMA	FNIYPGQ.
Enzyme and pathway databases
BioCyc	SAUR273036:SAB0414-MON.
Family and domain databases
InterPro	IPR007921. CHAP. IPR018392. Peptidoglycan-bd_lysin. IPR002482. Peptidoglycan-bd_Lysin_sg. [Graphical view]
Pfam	PF05257. CHAP. 1 hit. PF01476. LysM. 3 hits. [Graphical view]
SMART	SM00257. LysM. 3 hits. [Graphical view]
PROSITE	PS50911. CHAP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SLE1_STAAB

Accession

Primary (citable) accession number: Q2YVT4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	December 20, 2005
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)