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Q2YVF5 (THLA_STAAB) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable acetyl-CoA acyltransferase
EC=2.3.1.9
Alternative name(s):
Acetoacetyl-CoA thiolase
Gene names
Ordered Locus Names:SAB0304
OrganismStaphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]
Taxonomic identifier273036 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length393 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2 acetyl-CoA = CoA + acetoacetyl-CoA.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the thiolase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionacetyl-CoA C-acetyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 393393Probable acetyl-CoA acyltransferase
PRO_0000270502

Sites

Active site881Acyl-thioester intermediate By similarity
Active site3491Proton acceptor By similarity
Active site3781Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YVF5 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: C331F8215FEA47E7

FASTA39341,589
        10         20         30         40         50         60 
MTRVVLAAAY RTPIGVFGGA FKDVPAYDLG ATLIEHIIKE TGLNPSEINE VIIGNVLQAG 

        70         80         90        100        110        120 
QGQNPARIAA MKGGLPETVP VFTVNKVCGS GLKSIQLAYQ SIVTGENDIV LAGGMENMSQ 

       130        140        150        160        170        180 
SPMLVNNSRF GFKMGHQSMV DSMVYDGLTD VFNQYHMGIT AENLVEQYGI SREEQDTFAV 

       190        200        210        220        230        240 
NSQKKAANAQ QNGGFDSEIV PVSIPQRKGE PIVVTKDEGV RENVSVEKLS RLRPAFKKDG 

       250        260        270        280        290        300 
TVTAGNASGI NDGAAMMLVM SEDKAKELNI EPLAVLDGFG SHGVDPSIMG IAPVGAVEKA 

       310        320        330        340        350        360 
LKRSKKELSD IDVFELNEAF AAQSLAVDRE LKLPPEKVNV KGGAIALGHP IGASGARVLV 

       370        380        390 
TLLHQLNDEV ETGLTSLCIG GGQAIAAVVS KYK

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References

[1]"Molecular correlates of host specialization in Staphylococcus aureus."
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
PLoS ONE 2:E1120-E1120(2007) [PubMed: 17971880] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ938182 Genomic DNA. Translation: CAI79992.1.
RefSeqYP_415806.1. NC_007622.1.

3D structure databases

HSSPHSSP built from PDB template 2D3T based on UniProtKB P28790.
ProteinModelPortalQ2YVF5.
SMRQ2YVF5. Positions 4-390.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YVF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000013096; EBSTAP00000012753; EBSTAG00000013095.
GeneID3794322.
GenomeReviewsGene locus SAB0304 in contig AJ938182_GR.
KEGGsab:SAB0304.
NMPDRfig|273036.3.peg.318.
PATRIC19521337. VBIStaAur92441_0337.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0183.
GeneTreeEBGT00050000024085.
HOGENOMHBG370930.
OMANPSEINE.
PhylomeDBQ2YVF5.
ProtClustDBCLSK884583.

Enzyme and pathway databases

BioCycSAUR273036:SAB0304-MONOMER.

Family and domain databases

InterProIPR002155. Thiolase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
IPR020615. Thiolase_acyl_enz_int_AS.
IPR020610. Thiolase_AS.
IPR020617. Thiolase_C.
IPR020613. Thiolase_CS.
IPR020616. Thiolase_N.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 4 hits.
KOK00626.
PANTHERPTHR18919. Thiolase. 1 hit.
PfamPF02803. Thiolase_C. 1 hit.
PF00108. Thiolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000429. Ac-CoA_Ac_transf. 1 hit.
SUPFAMSSF53901. Thiolase-like. 2 hits.
TIGRFAMsTIGR01930. AcCoA-C-Actrans. 1 hit.
PROSITEPS00098. THIOLASE_1. 1 hit.
PS00737. THIOLASE_2. 1 hit.
PS00099. THIOLASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTHLA_STAAB
AccessionPrimary (citable) accession number: Q2YVF5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 20, 2005
Last modified: January 25, 2012
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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