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Q2YUN4

- KITH_STAAB

UniProt

Q2YUN4 - KITH_STAAB

Protein

Thymidine kinase

Gene

tdk

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi148 – 1481ZincUniRule annotation
    Metal bindingi183 – 1831ZincUniRule annotation
    Metal bindingi186 – 1861ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi15 – 228ATPUniRule annotation
    Nucleotide bindingi88 – 914ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    DNA synthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-2068-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    Ordered Locus Names:SAB2003c
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 199199Thymidine kinasePRO_0000242806Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi273036.SAB2003c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YUN4.
    SMRiQ2YUN4. Positions 7-192.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1435.
    HOGENOMiHOG000076390.
    KOiK00857.
    OMAiDEITAYI.
    OrthoDBiEOG69D3J2.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YUN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYETYHSGWI ECITGSMFSG KSEELIRRLR RGIYAKQKVV VFKPAIDDRY    50
    HKEKVVSHNG NAIEAINISK ASEIMTHDLT NVDVIGIDEV QFFDDEIVSI 100
    VEKLSADGHR VIVAGLDMDF RGEPFEPMPK LMAVSEQVTK LQAVCAVCGS 150
    SSSRTQRLIN GKPAKIDDPI ILVGANESYE PRCRAHHIVA PSDNNKEEL 199
    Length:199
    Mass (Da):22,214
    Last modified:December 20, 2005 - v1
    Checksum:iC1EC76B7C5645909
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81692.1.
    RefSeqiYP_417461.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI81692; CAI81692; SAB2003c.
    GeneIDi3792831.
    KEGGisab:SAB2003c.
    PATRICi19525011. VBIStaAur92441_2110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81692.1 .
    RefSeqi YP_417461.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YUN4.
    SMRi Q2YUN4. Positions 7-192.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB2003c.

    Chemistry

    BindingDBi Q2YUN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI81692 ; CAI81692 ; SAB2003c .
    GeneIDi 3792831.
    KEGGi sab:SAB2003c.
    PATRICi 19525011. VBIStaAur92441_2110.

    Phylogenomic databases

    eggNOGi COG1435.
    HOGENOMi HOG000076390.
    KOi K00857.
    OMAi DEITAYI.
    OrthoDBi EOG69D3J2.

    Enzyme and pathway databases

    BioCyci SAUR273036:GJVS-2068-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiKITH_STAAB
    AccessioniPrimary (citable) accession number: Q2YUN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3