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Protein

Sodium/proline symporter

Gene

putP

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sodium-dependent uptake of extracellular L-proline. Since most S.aureus strains are L-proline auxotrophs, this transporter may aid the bacterial persistence during an infection of tissues with low proline concentrations.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-1894-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/proline symporter
Alternative name(s):
Proline permease
Gene namesi
Name:putP
Ordered Locus Names:SAB1835
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei85 – 10521HelicalSequence analysisAdd
BLAST
Transmembranei139 – 15921HelicalSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei200 – 22021HelicalSequence analysisAdd
BLAST
Transmembranei240 – 26021HelicalSequence analysisAdd
BLAST
Transmembranei286 – 30621HelicalSequence analysisAdd
BLAST
Transmembranei327 – 34721HelicalSequence analysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST
Transmembranei467 – 48721HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Sodium/proline symporterPRO_0000364092Add
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000282935.
KOiK11928.
OMAiVHKFDLS.
OrthoDBiEOG6HB9QC.

Family and domain databases

InterProiIPR011851. Na/Pro_symporter.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02121. Na_Pro_sym. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YU74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMGTALSQ QVNANWQTYI MIAVYFLILI VIGFYGYKQA TGNLSEYMLG
60 70 80 90 100
GRSIGPYITA LSAGASDMSG WMIMGLPGSV YGTGLSAMWI TIGLTLGAYI
110 120 130 140 150
NYFVVAPRLR VYTELAGDAI TLPDFFKNRL NDKNNVLKII SGLIIVVFFT
160 170 180 190 200
LYTHSGFVSG GKLFESAFGL DYHFGLILVA FIVIFYTFFG GYLAVSITDF
210 220 230 240 250
FQGVIMLIAM VMVPIVAMMN LNGWGTFHDV AAMKPTNLNL FKGLSFIGTI
260 270 280 290 300
SLFSWGLGYF GQPHIIVRFM SIKSHKMLPK ARRLGISWMA VGLLGAVAVG
310 320 330 340 350
LTGIAFVPAY HIKLEDPETL FIVMSQVLFH PLVGGFLLAA ILAAIMSTIS
360 370 380 390 400
SQLLVTSSSL TEDFYKLIRG EEKAKTHQKE FVMIGRLSVL VVAIVAIAIA
410 420 430 440 450
WNPNDTILNL VGNAWAGFGA SFSPLVLFAL YWKGLTRAGA VSGMVSGALV
460 470 480 490 500
VIVWIAWIKP LAHINEIFGL YEIIPGFIVS VIVTYVVSKL TKKPGAFVET
510
DLNKVRDIVR EK
Length:512
Mass (Da):55,932
Last modified:December 20, 2005 - v1
Checksum:i90F12D127D332448
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81524.1.
RefSeqiWP_000957029.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81524; CAI81524; SAB1835.
KEGGisab:SAB1835.
PATRICi19524667. VBIStaAur92441_1944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81524.1.
RefSeqiWP_000957029.1. NC_007622.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI81524; CAI81524; SAB1835.
KEGGisab:SAB1835.
PATRICi19524667. VBIStaAur92441_1944.

Phylogenomic databases

HOGENOMiHOG000282935.
KOiK11928.
OMAiVHKFDLS.
OrthoDBiEOG6HB9QC.

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-1894-MONOMER.

Family and domain databases

InterProiIPR011851. Na/Pro_symporter.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02121. Na_Pro_sym. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiPUTP_STAAB
AccessioniPrimary (citable) accession number: Q2YU74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: December 20, 2005
Last modified: March 16, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.