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Q2YU46 (PTPA_STAAB) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low molecular weight protein-tyrosine-phosphatase PtpA

EC=3.1.3.48
Alternative name(s):
Phosphotyrosine phosphatase A
Short name=PTPase A
Gene names
Name:ptpA
Ordered Locus Names:SAB1813
OrganismStaphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]
Taxonomic identifier273036 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Dephosphorylates the phosphotyrosine-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sequence similarities

Belongs to the low molecular weight phosphotyrosine protein phosphatase family.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 154154Low molecular weight protein-tyrosine-phosphatase PtpA
PRO_0000300657

Sites

Active site81Nucleophile By similarity
Active site141 By similarity
Active site1201Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YU46 [UniParc].

Last modified December 20, 2005. Version 1.
Checksum: 67E81E1E9425A4FD

FASTA15417,551
        10         20         30         40         50         60 
MVDVAFVCLG NICRSPMAEA IMRQRLKDRN IHDIKVHSRG TGSWNLGEPP HEGTQKILNK 

        70         80         90        100        110        120 
HNIPFDGMIS ELFEATDDFD YIVAMDQSNV DNIKFINPNL KGQLFKLLEF SNMEESDVPD 

       130        140        150 
PYYTNNFEGV YDMVLSSCDN LIDYIVKDAN LKEG 

« Hide

References

[1]"Molecular correlates of host specialization in Staphylococcus aureus."
Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ938182 Genomic DNA. Translation: CAI81502.1.
RefSeqYP_417275.1. NC_007622.1.

3D structure databases

ProteinModelPortalQ2YU46.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING273036.SAB1813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAI81502; CAI81502; SAB1813.
GeneID3794216.
KEGGsab:SAB1813.
PATRIC19524613. VBIStaAur92441_1917.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0394.
HOGENOMHOG000273094.
KOK01104.
OMAGTGSWHV.
OrthoDBEOG6MH5JB.
ProtClustDBCLSK885622.

Enzyme and pathway databases

BioCycSAUR273036:GJVS-1872-MONOMER.

Family and domain databases

InterProIPR023485. Ptyr_pPase_SF.
IPR000106. Tyr_phospatase/Ars_reductase.
IPR017867. Tyr_phospatase_low_mol_wt.
[Graphical view]
PANTHERPTHR11717. PTHR11717. 1 hit.
PfamPF01451. LMWPc. 1 hit.
[Graphical view]
PRINTSPR00719. LMWPTPASE.
SMARTSM00226. LMWPc. 1 hit.
[Graphical view]
SUPFAMSSF52788. SSF52788. 1 hit.
ProtoNetSearch...

Entry information

Entry namePTPA_STAAB
AccessionPrimary (citable) accession number: Q2YU46
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 20, 2005
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families