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Protein

Septation ring formation regulator EzrA

Gene

ezrA

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.UniRule annotation

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Septation

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-1598-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Septation ring formation regulator EzrAUniRule annotation
Gene namesi
Name:ezrAUniRule annotation
Ordered Locus Names:SAB1576c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation

  • Note: Colocalized with FtsZ to the nascent septal site.UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 44ExtracellularUniRule annotation
Transmembranei5 – 2319HelicalUniRule annotationAdd
BLAST
Topological domaini24 – 564541CytoplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 564564Septation ring formation regulator EzrAPRO_1000045904Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ2YTH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili99 – 13840UniRule annotationAdd
BLAST
Coiled coili190 – 22334UniRule annotationAdd
BLAST
Coiled coili271 – 30030UniRule annotationAdd
BLAST
Coiled coili350 – 43586UniRule annotationAdd
BLAST
Coiled coili471 – 55080UniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EzrA family.UniRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000090114.
KOiK06286.
OMAiLTINTQI.
OrthoDBiEOG6R87DK.

Family and domain databases

HAMAPiMF_00728. EzrA.
InterProiIPR010379. EzrA.
[Graphical view]
PfamiPF06160. EzrA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YTH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLYIILAII VIILIAVGVL FYLRSNKRQI IEKAIERKNE IETLPFDQNL
60 70 80 90 100
AQLSKLNLKG ETKTKYDAMK KDNVESTNKY LAPVEEKIHN AEALLDKFSF
110 120 130 140 150
NASQSEIDDA NELMDSYEQS YQQQLEDVNE IIALYKDNDE LYDKCKVDYR
160 170 180 190 200
EMKRDVLANR HQFGEAASLL ETEIEKFEPR LEQYEVLKAD GNYVQAHNHI
210 220 230 240 250
AALNEQMKQL RSYMEEIPEL IRETQKELPG QFQDLKYGCR DLKVEGYDLD
260 270 280 290 300
HVKVDSTLQS LKTELSFVEP LISRLELEEA NDKLANINDK LDDMYDLIEH
310 320 330 340 350
EVKAKNDVEE TKDIITDNLF KAKDMNYTLQ TEIEYVRENY YINESDAQSV
360 370 380 390 400
RQFENEIQSL ISVYDDILKE MSKSAVRYSE VQDNLQYLED HVTVINDKQE
410 420 430 440 450
KLQNHLIQLR EDEAEAEDNL LRVQSKKEEV YRRLLASNLT SVPERFIIMK
460 470 480 490 500
NEIDHEVRDV NEQFSERPIH VKQLKDKVSK IVIQMNTFED EANDVLVNAV
510 520 530 540 550
YAEKLIQYGN RYRKDYSNVD KSLNEAERLF KNNRYKRAIE IAEQALESVE
560
PGVTKHIEEE VIKQ
Length:564
Mass (Da):66,200
Last modified:December 20, 2005 - v1
Checksum:i4DE5BC982B9E7489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81265.1.
RefSeqiWP_000244865.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81265; CAI81265; SAB1576c.
KEGGisab:SAB1576c.
PATRICi19524047. VBIStaAur92441_1672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81265.1.
RefSeqiWP_000244865.1. NC_007622.1.

3D structure databases

ProteinModelPortaliQ2YTH2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAI81265; CAI81265; SAB1576c.
KEGGisab:SAB1576c.
PATRICi19524047. VBIStaAur92441_1672.

Phylogenomic databases

HOGENOMiHOG000090114.
KOiK06286.
OMAiLTINTQI.
OrthoDBiEOG6R87DK.

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-1598-MONOMER.

Family and domain databases

HAMAPiMF_00728. EzrA.
InterProiIPR010379. EzrA.
[Graphical view]
PfamiPF06160. EzrA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiEZRA_STAAB
AccessioniPrimary (citable) accession number: Q2YTH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: March 16, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.