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Protein

Septation ring formation regulator EzrA

Gene

ezrA

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization.UniRule annotation

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Septation

Names & Taxonomyi

Protein namesi
Recommended name:
Septation ring formation regulator EzrAUniRule annotation
Gene namesi
Name:ezrAUniRule annotation
Ordered Locus Names:SAB1576c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cell membrane UniRule annotation; Single-pass membrane protein UniRule annotation
  • Note: Colocalized with FtsZ to the nascent septal site.UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4ExtracellularUniRule annotation4
Transmembranei5 – 23HelicalUniRule annotationAdd BLAST19
Topological domaini24 – 564CytoplasmicUniRule annotationAdd BLAST541

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000459041 – 564Septation ring formation regulator EzrAAdd BLAST564

Structurei

3D structure databases

ProteinModelPortaliQ2YTH2
SMRiQ2YTH2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili99 – 138UniRule annotationAdd BLAST40
Coiled coili190 – 223UniRule annotationAdd BLAST34
Coiled coili271 – 300UniRule annotationAdd BLAST30
Coiled coili350 – 435UniRule annotationAdd BLAST86
Coiled coili471 – 550UniRule annotationAdd BLAST80

Sequence similaritiesi

Belongs to the EzrA family.UniRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000090114
KOiK06286
OMAiVEPMISR

Family and domain databases

HAMAPiMF_00728 EzrA, 1 hit
InterProiView protein in InterPro
IPR010379 EzrA
PfamiView protein in Pfam
PF06160 EzrA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YTH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLYIILAII VIILIAVGVL FYLRSNKRQI IEKAIERKNE IETLPFDQNL
60 70 80 90 100
AQLSKLNLKG ETKTKYDAMK KDNVESTNKY LAPVEEKIHN AEALLDKFSF
110 120 130 140 150
NASQSEIDDA NELMDSYEQS YQQQLEDVNE IIALYKDNDE LYDKCKVDYR
160 170 180 190 200
EMKRDVLANR HQFGEAASLL ETEIEKFEPR LEQYEVLKAD GNYVQAHNHI
210 220 230 240 250
AALNEQMKQL RSYMEEIPEL IRETQKELPG QFQDLKYGCR DLKVEGYDLD
260 270 280 290 300
HVKVDSTLQS LKTELSFVEP LISRLELEEA NDKLANINDK LDDMYDLIEH
310 320 330 340 350
EVKAKNDVEE TKDIITDNLF KAKDMNYTLQ TEIEYVRENY YINESDAQSV
360 370 380 390 400
RQFENEIQSL ISVYDDILKE MSKSAVRYSE VQDNLQYLED HVTVINDKQE
410 420 430 440 450
KLQNHLIQLR EDEAEAEDNL LRVQSKKEEV YRRLLASNLT SVPERFIIMK
460 470 480 490 500
NEIDHEVRDV NEQFSERPIH VKQLKDKVSK IVIQMNTFED EANDVLVNAV
510 520 530 540 550
YAEKLIQYGN RYRKDYSNVD KSLNEAERLF KNNRYKRAIE IAEQALESVE
560
PGVTKHIEEE VIKQ
Length:564
Mass (Da):66,200
Last modified:December 20, 2005 - v1
Checksum:i4DE5BC982B9E7489
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81265.1
RefSeqiWP_000244865.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI81265; CAI81265; SAB1576c
KEGGisab:SAB1576c

Similar proteinsi

Entry informationi

Entry nameiEZRA_STAAB
AccessioniPrimary (citable) accession number: Q2YTH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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