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Q2YTE6

- Q2YTE6_STAAB

UniProt

Q2YTE6 - Q2YTE6_STAAB

Protein

Isocitrate dehydrogenase [NADP]

Gene

citC

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-1575-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:citCImported
    Ordered Locus Names:SAB1553cImported
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)Imported
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    Interactioni

    Protein-protein interaction databases

    STRINGi273036.SAB1553c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YTE6.
    SMRiQ2YTE6. Positions 3-421.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiITEEMIV.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YTE6-1 [UniParc]FASTAAdd to Basket

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    MTAEKITQGT EGLNVPNEPI IPFIIGDGIG PDIWKAASRV IDAAVEKAYN    50
    GEKRIEWKEV LAGQKAFDTT GEWLPQETLD TIKEYLIAVK GPLTTPIGGG 100
    IRSLNVALRQ ELDLFTCLRP VRWFKGVPSP VKRPQDVDMV IFRENTEDIY 150
    AGIEFKEGTT EVKKVIDFLQ NEMGATNIRF PETSGIGIKP VSKEGTERLA 200
    RAAIQYAIDN NRKSVTLVHK GNIMKFTEGS FKQWGYDLAL TEFGDQVFTW 250
    QQYDEIVENE GRDAANAAQE KAEKEGKIII KDSIADIFLQ QILTRPAEHD 300
    VVATMNLNGD YISDALAAQV GGIGIAPGAN INYETGHAIF EATHGTAPKY 350
    AGLNKVNPSS VILSSVLMLE HLGWQEAADK ITDSIEDTIA SKVVTYDFAR 400
    LMDGAEEVST SSFADELIKN LK 422
    Length:422
    Mass (Da):46,425
    Last modified:December 20, 2005 - v1
    Checksum:iA62D4EF8AAF6A5DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81242.1.
    RefSeqiWP_000123162.1. NC_007622.1.
    YP_417023.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI81242; CAI81242; SAB1553c.
    GeneIDi3794416.
    KEGGisab:SAB1553c.
    PATRICi19524003. VBIStaAur92441_1650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI81242.1 .
    RefSeqi WP_000123162.1. NC_007622.1.
    YP_417023.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YTE6.
    SMRi Q2YTE6. Positions 3-421.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB1553c.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI81242 ; CAI81242 ; SAB1553c .
    GeneIDi 3794416.
    KEGGi sab:SAB1553c.
    PATRICi 19524003. VBIStaAur92441_1650.

    Phylogenomic databases

    eggNOGi COG0538.
    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi ITEEMIV.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci SAUR273036:GJVS-1575-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1Imported.

    Entry informationi

    Entry nameiQ2YTE6_STAAB
    AccessioniPrimary (citable) accession number: Q2YTE6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 20, 2005
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3