Q2YTC2 (GSA1_STAAB) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1
Short name=GSA 1
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name=GSA-AT 1

Gene names

Name:	hemL1
Ordered Locus Names:	SAB1527c

Organism

Staphylococcus aureus (strain bovine RF122 / ET3-1) [Complete proteome] [HAMAP]

Taxonomic identifier

273036 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Glutamate-1-semialdehyde 2,1-aminomutase 1 HAMAP-Rule MF_00375		PRO_0000243619
Amino acid modifications
	Modified residue	267	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2YTC2 [UniParc]. Last modified December 20, 2005. Version 1. Checksum: 6304390735FFEE66	FASTA	428	46,364
	10 20 30 40 50 60 MRYTKSEEAM KVAETLMPGG VNSPVRAFKS VDTPAIFMDH GKGSKIYDID GNEYIDYVLS 70 80 90 100 110 120 WGPLILGHRD PQVISHLHEA IDKGTSFGAS TLLENKLAQL VIDRVPSIEK VRMVSSGTEA 130 140 150 160 170 180 TLDTLRLARG YTGRNKIVKF EGCYHGHSDS LLIKAGSGVA TLGLPDSPGV PEGIAKNTIT 190 200 210 220 230 240 VPYNDLDALK IAFEKFGDDI AGVIVEPVAG NMGVIPPIEG FLQGLRDITT EYGALLIFDE 250 260 270 280 290 300 VMTGFRVGYH CAQGYFGVTP DLTCLGKVIG GGLPVGAFGG KKEIMDQIAP LGNIYQAGTL 310 320 330 340 350 360 SGNPLAMTSG YETLSQLAPE TYEYFNMLGD ILEDGLKRVF AKHNVPITVN RAGSMIGYFL 370 380 390 400 410 420 NEGPVTNFEQ ANKSDLKLFA EMYREMAKEG VFLPPSQFEG TFLSTAHTKE DIEKTIQAFD TALSRIVK

References

[1]	"Molecular correlates of host specialization in Staphylococcus aureus." Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V. PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: bovine RF122 / ET3-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ938182 Genomic DNA. Translation: CAI81216.1.
RefSeq	YP_416997.1. NC_007622.1.
3D structure databases
ProteinModelPortal	Q2YTC2.
SMR	Q2YTC2. Positions 1-426.
ModBase	Search...
Protein-protein interaction databases
STRING	273036.SAB1527c.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAI81216; CAI81216; SAB1527c.
GeneID	3794911.
KEGG	sab:SAB1527c.
PATRIC	19523951. VBIStaAur92441_1624.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	FNGNPIS.
ProtClustDB	PRK00062.
Enzyme and pathway databases
BioCyc	SAUR273036:GJVS-1549-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA1_STAAB

Accession

Primary (citable) accession number: Q2YTC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 20, 2005
Last modified:	May 29, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program