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Protein

Dephospho-CoA kinase

Gene

coaE

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.UniRule annotation

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type II pantothenate kinase (coaW)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAUR273036:G1G1D-1702-MONOMER
UniPathwayiUPA00241; UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinaseUniRule annotation (EC:2.7.1.24UniRule annotation)
Alternative name(s):
Dephosphocoenzyme A kinaseUniRule annotation
Gene namesi
Name:coaEUniRule annotation
Ordered Locus Names:SAB1547c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002433441 – 207Dephospho-CoA kinaseAdd BLAST207

Proteomic databases

PRIDEiQ2YTA2

Structurei

3D structure databases

ProteinModelPortaliQ2YTA2
SMRiQ2YTA2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 203DPCKUniRule annotationAdd BLAST200

Sequence similaritiesi

Belongs to the CoaE family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000020768
KOiK00859
OMAiLVTEIWV

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YTA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVIGLTGG IASGKSTVSE LLSVFGFKVV DADKAAREAV KKGSKGLAQV
60 70 80 90 100
REVFGDEAID ENGEMNRRYM GDLVFNHPEK RLELNAIIHP IVRDIMEEEK
110 120 130 140 150
QEYLKQGYNV IMDIPLLFEN ELENTVDEVW VIYTSESIQM DRLMQRNNLS
160 170 180 190 200
LEDAKARVYS QISIDKKSRM ADHVIDNLGD KLELKQNLER LLKEEGYIEK

PNYGEED
Length:207
Mass (Da):23,636
Last modified:December 20, 2005 - v1
Checksum:i8E56BAF6FDC6BB66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81236.1
RefSeqiWP_001127162.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI81236; CAI81236; SAB1547c
KEGGisab:SAB1547c

Similar proteinsi

Entry informationi

Entry nameiCOAE_STAAB
AccessioniPrimary (citable) accession number: Q2YTA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 20, 2005
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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