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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA recombination, DNA repair, SOS response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:SAB1511c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000025651 – 200Holliday junction ATP-dependent DNA helicase RuvAAdd BLAST200

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YT88
SMRiQ2YT88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000057116
KOiK03550
OMAiDCHGVGY

Family and domain databases

CDDicd14332 UBA_RuvA_C, 1 hit
HAMAPiMF_00031 DNA_helic_RuvA, 1 hit
InterProiView protein in InterPro
IPR013849 DNA_helicase_Holl-junc_RuvA_I
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR012340 NA-bd_OB-fold
IPR000085 RuvA
IPR010994 RuvA_2-like
IPR011114 RuvA_C
IPR036267 RuvA_C_sf
PANTHERiPTHR33796 PTHR33796, 1 hit
PfamiView protein in Pfam
PF07499 RuvA_C, 1 hit
PF01330 RuvA_N, 1 hit
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SUPFAMiSSF46929 SSF46929, 1 hit
SSF47781 SSF47781, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00084 ruvA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YT88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAYVKGKLT HLYPTHVVVE TAGVGYEIQT PNSYRFQKHL DHEVLIHTSL
60 70 80 90 100
IVREDAQLLY GFSSEEEKDM FLSLIKVTGI GPKSALAILA TSTPNEVKRA
110 120 130 140 150
IENENDTYLT KFPGIGKKTA RQIVLDLKGK VKITEEDSDS LLQVDATSTV
160 170 180 190 200
QDQFVQEAML ALEALGYSKR ELAKVEKTLN KNKYDSVDEA VKAGLQLVVS
Length:200
Mass (Da):22,262
Last modified:December 20, 2005 - v1
Checksum:i26C01F793C058574
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA Translation: CAI81200.1
RefSeqiWP_000271547.1, NC_007622.1

Genome annotation databases

EnsemblBacteriaiCAI81200; CAI81200; SAB1511c
KEGGisab:SAB1511c

Entry informationi

Entry nameiRUVA_STAAB
AccessioniPrimary (citable) accession number: Q2YT88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health