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Protein

Probable endonuclease 4

Gene

nfo

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.IEP:

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.IEP:

Cofactori

Zn2+IEP:Note: Binds 3 Zn2+ ions.IEP:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Zinc 1IEP:1
Metal bindingi109Zinc 1IEP:1
Metal bindingi144Zinc 1IEP:1
Metal bindingi144Zinc 2IEP:1
Metal bindingi178Zinc 2IEP:1
Metal bindingi181Zinc 3IEP:1
Metal bindingi213Zinc 2IEP:1
Metal bindingi226Zinc 3IEP:1
Metal bindingi228Zinc 3IEP:1
Metal bindingi258Zinc 2IEP:1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endonuclease 4IEP: (EC:3.1.21.2IEP:)
Alternative name(s):
Endodeoxyribonuclease IVIEP:
Endonuclease IVIEP:
Gene namesi
Name:nfoIEP:
Ordered Locus Names:SAB1429c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000113391 – 296Probable endonuclease 4Add BLAST296

Structurei

3D structure databases

ProteinModelPortaliQ2YT22.
SMRiQ2YT22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AP endonuclease 2 family.IEP:

Phylogenomic databases

HOGENOMiHOG000224895.
KOiK01151.
OMAiHPGSHLK.

Family and domain databases

CDDicd00019. AP2Ec. 1 hit.
HAMAPiMF_00152. Nfo. 1 hit.
InterProiView protein in InterPro
IPR001719. AP_endonuc_2.
IPR018246. AP_endonuc_F2_Zn_BS.
IPR036237. Xyl_isomerase-like_sf.
IPR013022. Xyl_isomerase-like_TIM-brl.
PANTHERiPTHR21445. PTHR21445. 1 hit.
PfamiView protein in Pfam
PF01261. AP_endonuc_2. 1 hit.
SMARTiView protein in SMART
SM00518. AP2Ec. 1 hit.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR00587. nfo. 1 hit.
PROSITEiView protein in PROSITE
PS00729. AP_NUCLEASE_F2_1. 1 hit.
PS00730. AP_NUCLEASE_F2_2. 1 hit.
PS00731. AP_NUCLEASE_F2_3. 1 hit.
PS51432. AP_NUCLEASE_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YT22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLGSHVSMS GKKMLEGSAI EAHEYGETTF MIYTGAPQNT RRKSIEDLNI
60 70 80 90 100
TKGHEVMEKY GLSNIVVHAP YIINIANTTK PETFNLGVDF LQQEIERTQA
110 120 130 140 150
IGAKDIVLHP GAHVGAGVDA GINKIIEGLN EVLTNDNNVR IALETMAGKG
160 170 180 190 200
TEIGRSFEEL ARIIDGVHNN ERLSVCFDTC HTHDAGYNVK EDFDGVLNEF
210 220 230 240 250
DKIIGVDRIK VVHVNDSKND RGAQKDRHEN IGFGYIGFDA LNYIVHHDSF
260 270 280 290
KDIPKILETP YVGEDKKNKK PPYKLEIEML KQQQFDPELK NKVMQQ
Length:296
Mass (Da):33,159
Last modified:December 20, 2005 - v1
Checksum:i6B35AF57AF97914D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI81118.1.
RefSeqiWP_000924214.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI81118; CAI81118; SAB1429c.
KEGGisab:SAB1429c.

Similar proteinsi

Entry informationi

Entry nameiEND4_STAAB
AccessioniPrimary (citable) accession number: Q2YT22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: December 20, 2005
Last modified: October 25, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families