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Q2YSI6

- PEPT_STAAB

UniProt

Q2YSI6 - PEPT_STAAB

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Protein

Peptidase T

Gene

pepT

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

Catalytic activityi

Release of the N-terminal residue from a tripeptide.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn(2+) ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi78 – 781Zinc 1UniRule annotation
Active sitei80 – 801UniRule annotation
Metal bindingi140 – 1401Zinc 1UniRule annotation
Metal bindingi140 – 1401Zinc 2UniRule annotation
Active sitei174 – 1741Proton acceptorUniRule annotation
Metal bindingi175 – 1751Zinc 2UniRule annotation
Metal bindingi197 – 1971Zinc 1UniRule annotation
Metal bindingi379 – 3791Zinc 2UniRule annotation

GO - Molecular functioni

  1. metallopeptidase activity Source: UniProtKB-KW
  2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. peptide metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciSAUR273036:GJVS-714-MONOMER.

Protein family/group databases

MEROPSiM20.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
Alternative name(s):
AminotripeptidaseUniRule annotation
Short name:
TripeptidaseUniRule annotation
Tripeptide aminopeptidaseUniRule annotation
Gene namesi
Name:pepTUniRule annotation
Ordered Locus Names:SAB0695c
OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
Taxonomic identifieri273036 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001927: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 408408Peptidase TPRO_0000274021Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi273036.SAB0695c.

Structurei

3D structure databases

ProteinModelPortaliQ2YSI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20B family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2195.
HOGENOMiHOG000032390.
KOiK01258.
OMAiYVKIYST.
OrthoDBiEOG6SV59Q.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_00550. Aminopeptidase_M20.
InterProiIPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YSI6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKNQLIDRLT RYTTIDTQSD PKSTTTPSTE KQWDLLHLLE RELQQLGLPT
60 70 80 90 100
DLDENGYLFA TLESNIDADV PTVGFLAHVD TSPDFNASNV KPQIIENYDS
110 120 130 140 150
KPYKLGNTKR VLDPKVFPEL NSLVGHTLMV TDGTSLLGAD DKAGIVEIME
160 170 180 190 200
AICYLQEHPE IKHGTIRIGF TPDEEIGRGP HKFDVDRFNA DFAYTMDGSQ
210 220 230 240 250
YGELQYESFN AAEAVITCHG VNVHPGSAKN AMVNAIRLGE QFDSLLPDSE
260 270 280 290 300
VPERTEGYEG FYHLMNFEGT VEKATLQYII RDHDKKQFEL RKKRILEIRD
310 320 330 340 350
DINAHFENYP VKVDISDQYF NMAEKILPLP HIIDIPKRVF AKLDIPANTE
360 370 380 390 400
PIRGGTDGSQ LSFMGLPTPN IFTGCGNFHG PYEYASIDVM EKAVQVIIGI

VEDIAENN
Length:408
Mass (Da):45,855
Last modified:December 20, 2005 - v1
Checksum:i16B7207F9C35184C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI80383.1.
RefSeqiWP_000795830.1. NC_007622.1.
YP_416188.1. NC_007622.1.

Genome annotation databases

EnsemblBacteriaiCAI80383; CAI80383; SAB0695c.
GeneIDi3794463.
KEGGisab:SAB0695c.
PATRICi19522185. VBIStaAur92441_0744.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ938182 Genomic DNA. Translation: CAI80383.1 .
RefSeqi WP_000795830.1. NC_007622.1.
YP_416188.1. NC_007622.1.

3D structure databases

ProteinModelPortali Q2YSI6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 273036.SAB0695c.

Protein family/group databases

MEROPSi M20.003.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAI80383 ; CAI80383 ; SAB0695c .
GeneIDi 3794463.
KEGGi sab:SAB0695c.
PATRICi 19522185. VBIStaAur92441_0744.

Phylogenomic databases

eggNOGi COG2195.
HOGENOMi HOG000032390.
KOi K01258.
OMAi YVKIYST.
OrthoDBi EOG6SV59Q.

Enzyme and pathway databases

BioCyci SAUR273036:GJVS-714-MONOMER.

Family and domain databases

Gene3Di 3.30.70.360. 1 hit.
HAMAPi MF_00550. Aminopeptidase_M20.
InterProi IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
IPR010161. Peptidase_M20B.
[Graphical view ]
Pfami PF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view ]
PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
SUPFAMi SSF55031. SSF55031. 1 hit.
TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular correlates of host specialization in Staphylococcus aureus."
    Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
    PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: bovine RF122 / ET3-1.

Entry informationi

Entry nameiPEPT_STAAB
AccessioniPrimary (citable) accession number: Q2YSI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: December 20, 2005
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3