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Q2YSI6

- PEPT_STAAB

UniProt

Q2YSI6 - PEPT_STAAB

Protein

Peptidase T

Gene

pepT

Organism
Staphylococcus aureus (strain bovine RF122 / ET3-1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Cleaves the N-terminal amino acid of tripeptides.UniRule annotation

    Catalytic activityi

    Release of the N-terminal residue from a tripeptide.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi78 – 781Zinc 1UniRule annotation
    Active sitei80 – 801UniRule annotation
    Metal bindingi140 – 1401Zinc 1UniRule annotation
    Metal bindingi140 – 1401Zinc 2UniRule annotation
    Active sitei174 – 1741Proton acceptorUniRule annotation
    Metal bindingi175 – 1751Zinc 2UniRule annotation
    Metal bindingi197 – 1971Zinc 1UniRule annotation
    Metal bindingi379 – 3791Zinc 2UniRule annotation

    GO - Molecular functioni

    1. metallopeptidase activity Source: UniProtKB-KW
    2. tripeptide aminopeptidase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. peptide metabolic process Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciSAUR273036:GJVS-714-MONOMER.

    Protein family/group databases

    MEROPSiM20.003.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Peptidase TUniRule annotation (EC:3.4.11.4UniRule annotation)
    Alternative name(s):
    AminotripeptidaseUniRule annotation
    Short name:
    TripeptidaseUniRule annotation
    Tripeptide aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepTUniRule annotation
    Ordered Locus Names:SAB0695c
    OrganismiStaphylococcus aureus (strain bovine RF122 / ET3-1)
    Taxonomic identifieri273036 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001927: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 408408Peptidase TPRO_0000274021Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi273036.SAB0695c.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YSI6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M20B family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2195.
    HOGENOMiHOG000032390.
    KOiK01258.
    OMAiYVKIYST.
    OrthoDBiEOG6SV59Q.

    Family and domain databases

    Gene3Di3.30.70.360. 1 hit.
    HAMAPiMF_00550. Aminopeptidase_M20.
    InterProiIPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view]
    PfamiPF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMiSSF55031. SSF55031. 1 hit.
    TIGRFAMsiTIGR01882. peptidase-T. 1 hit.
    PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YSI6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKNQLIDRLT RYTTIDTQSD PKSTTTPSTE KQWDLLHLLE RELQQLGLPT    50
    DLDENGYLFA TLESNIDADV PTVGFLAHVD TSPDFNASNV KPQIIENYDS 100
    KPYKLGNTKR VLDPKVFPEL NSLVGHTLMV TDGTSLLGAD DKAGIVEIME 150
    AICYLQEHPE IKHGTIRIGF TPDEEIGRGP HKFDVDRFNA DFAYTMDGSQ 200
    YGELQYESFN AAEAVITCHG VNVHPGSAKN AMVNAIRLGE QFDSLLPDSE 250
    VPERTEGYEG FYHLMNFEGT VEKATLQYII RDHDKKQFEL RKKRILEIRD 300
    DINAHFENYP VKVDISDQYF NMAEKILPLP HIIDIPKRVF AKLDIPANTE 350
    PIRGGTDGSQ LSFMGLPTPN IFTGCGNFHG PYEYASIDVM EKAVQVIIGI 400
    VEDIAENN 408
    Length:408
    Mass (Da):45,855
    Last modified:December 20, 2005 - v1
    Checksum:i16B7207F9C35184C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI80383.1.
    RefSeqiYP_416188.1. NC_007622.1.

    Genome annotation databases

    EnsemblBacteriaiCAI80383; CAI80383; SAB0695c.
    GeneIDi3794463.
    KEGGisab:SAB0695c.
    PATRICi19522185. VBIStaAur92441_0744.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ938182 Genomic DNA. Translation: CAI80383.1 .
    RefSeqi YP_416188.1. NC_007622.1.

    3D structure databases

    ProteinModelPortali Q2YSI6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 273036.SAB0695c.

    Protein family/group databases

    MEROPSi M20.003.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAI80383 ; CAI80383 ; SAB0695c .
    GeneIDi 3794463.
    KEGGi sab:SAB0695c.
    PATRICi 19522185. VBIStaAur92441_0744.

    Phylogenomic databases

    eggNOGi COG2195.
    HOGENOMi HOG000032390.
    KOi K01258.
    OMAi YVKIYST.
    OrthoDBi EOG6SV59Q.

    Enzyme and pathway databases

    BioCyci SAUR273036:GJVS-714-MONOMER.

    Family and domain databases

    Gene3Di 3.30.70.360. 1 hit.
    HAMAPi MF_00550. Aminopeptidase_M20.
    InterProi IPR001261. ArgE/DapE_CS.
    IPR002933. Peptidase_M20.
    IPR011650. Peptidase_M20_dimer.
    IPR010161. Peptidase_M20B.
    [Graphical view ]
    Pfami PF07687. M20_dimer. 1 hit.
    PF01546. Peptidase_M20. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037215. Peptidase_M20B. 1 hit.
    SUPFAMi SSF55031. SSF55031. 1 hit.
    TIGRFAMsi TIGR01882. peptidase-T. 1 hit.
    PROSITEi PS00758. ARGE_DAPE_CPG2_1. 1 hit.
    PS00759. ARGE_DAPE_CPG2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular correlates of host specialization in Staphylococcus aureus."
      Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.
      PLoS ONE 2:E1120-E1120(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: bovine RF122 / ET3-1.

    Entry informationi

    Entry nameiPEPT_STAAB
    AccessioniPrimary (citable) accession number: Q2YSI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3