SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q2YRV0

- Q2YRV0_BRUA2

UniProt

Q2YRV0 - Q2YRV0_BRUA2

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Isocitrate dehydrogenase [NADP]
Gene
BAB1_1221
Organism
Brucella abortus (strain 2308)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei82 – 821NADP By similarity
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Binding sitei258 – 2581NADP By similarity
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation
Binding sitei326 – 3261NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADP By similarity
Nucleotide bindingi308 – 3136NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1243-MONOMER.
BMEL359391:GJOQ-1243-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:BAB1_1221Imported
OrganismiBrucella abortus (strain 2308)Imported
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_1221.

Structurei

3D structure databases

ProteinModelPortaliQ2YRV0.
SMRiQ2YRV0. Positions 3-403.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
HOGENOMiHOG000019858.
KOiK00031.
OMAiKNTIMKV.
OrthoDBiEOG628F3X.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YRV0-1 [UniParc]FASTAAdd to Basket

« Hide

MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD    50
ATNDQVTIDA ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR 100
NILGGVIFRE PIICKNVPRL VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG 150
TLTIKFVGED GQTIEHEVYQ APSAGVAMAM YNLDESIREF ARASFNYGLQ 200
RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK KIWYEHRLID 250
DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 300
VEAEAAHGTV TRHYRQHQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL 350
KKFAETLEKV CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK 400
AMAA 404
Length:404
Mass (Da):45,455
Last modified:February 7, 2006 - v1
Checksum:i453241CC1A59DC48
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11177.1.
RefSeqiYP_414607.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11177; CAJ11177; BAB1_1221.
GeneIDi3787843.
KEGGibmf:BAB1_1221.
PATRICi17845395. VBIBruMel86222_1267.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11177.1 .
RefSeqi YP_414607.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YRV0.
SMRi Q2YRV0. Positions 3-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1221.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11177 ; CAJ11177 ; BAB1_1221 .
GeneIDi 3787843.
KEGGi bmf:BAB1_1221.
PATRICi 17845395. VBIBruMel86222_1267.

Phylogenomic databases

eggNOGi COG0538.
HOGENOMi HOG000019858.
KOi K00031.
OMAi KNTIMKV.
OrthoDBi EOG628F3X.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1243-MONOMER.
BMEL359391:GJOQ-1243-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308Imported.

Entry informationi

Entry nameiQ2YRV0_BRUA2
AccessioniPrimary (citable) accession number: Q2YRV0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 7, 2006
Last sequence update: February 7, 2006
Last modified: July 9, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi