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Q2YRR5

- TRPD_BRUA2

UniProt

Q2YRR5 - TRPD_BRUA2

Protein

Anthranilate phosphoribosyltransferase

Gene

trpD

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).UniRule annotation

    Catalytic activityi

    N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per monomer.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei81 – 811Anthranilate 1; via carbonyl oxygenUniRule annotation
    Binding sitei81 – 811Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
    Binding sitei89 – 891PhosphoribosylpyrophosphateUniRule annotation
    Metal bindingi93 – 931Magnesium 1UniRule annotation
    Binding sitei112 – 1121Anthranilate 1UniRule annotation
    Binding sitei121 – 1211Phosphoribosylpyrophosphate; via amide nitrogenUniRule annotation
    Binding sitei167 – 1671Anthranilate 2UniRule annotation
    Metal bindingi225 – 2251Magnesium 2UniRule annotation
    Metal bindingi226 – 2261Magnesium 1UniRule annotation
    Metal bindingi226 – 2261Magnesium 2UniRule annotation

    GO - Molecular functioni

    1. anthranilate phosphoribosyltransferase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophan biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1185-MONOMER.
    BMEL359391:GJOQ-1185-MONOMER.
    UniPathwayiUPA00035; UER00041.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anthranilate phosphoribosyltransferaseUniRule annotation (EC:2.4.2.18UniRule annotation)
    Gene namesi
    Name:trpDUniRule annotation
    Ordered Locus Names:BAB1_1163
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Anthranilate phosphoribosyltransferasePRO_0000227140Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1163.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YRR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni84 – 852Phosphoribosylpyrophosphate bindingUniRule annotation
    Regioni91 – 944Phosphoribosylpyrophosphate bindingUniRule annotation
    Regioni109 – 1179Phosphoribosylpyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the anthranilate phosphoribosyltransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0547.
    HOGENOMiHOG000230451.
    KOiK00766.
    OMAiQPFPRPD.
    OrthoDBiEOG6D5G6B.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    HAMAPiMF_00211. TrpD.
    InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    [Graphical view]
    PfamiPF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    TIGRFAMsiTIGR01245. trpD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YRR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADLKPYIAK AASGEPLPLG DAKAAFDIMM SGQATPSQIG GFLMALRVRG    50
    ETVPEIAGAV ASMRSRMIPV IAPDDAMDIV GTGGDQSGSY NVSSCTAFVV 100
    AGAGVPVAKH GNRALSSRSG AADALAALGI NIEADADTIG RSISEAGLGF 150
    MFAPMHHSAM RHVGPSRVEL GTRTIFNLLG PLSNPASVKR QLVGVFAPQW 200
    LEPLAHVLKE LGSETAWVVY GDGLDEMTTA GTTQVAALEN GQIRTFEITP 250
    EEVGLRRCSP AELKGGEAAE NAKALLGVLE GKDSAYRDIV LLNSGAALVV 300
    AGKAENLKDG IAQAVQSIDS GAALAVLQKV IAVSNDKPA 339
    Length:339
    Mass (Da):34,839
    Last modified:February 7, 2006 - v1
    Checksum:i182891532AE4FCDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11119.1.
    RefSeqiYP_414554.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11119; CAJ11119; BAB1_1163.
    GeneIDi3787802.
    KEGGibmf:BAB1_1163.
    PATRICi17845281. VBIBruMel86222_1210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11119.1 .
    RefSeqi YP_414554.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YRR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1163.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11119 ; CAJ11119 ; BAB1_1163 .
    GeneIDi 3787802.
    KEGGi bmf:BAB1_1163.
    PATRICi 17845281. VBIBruMel86222_1210.

    Phylogenomic databases

    eggNOGi COG0547.
    HOGENOMi HOG000230451.
    KOi K00766.
    OMAi QPFPRPD.
    OrthoDBi EOG6D5G6B.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00041 .
    BioCyci BABO359391:GKDV-1185-MONOMER.
    BMEL359391:GJOQ-1185-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    HAMAPi MF_00211. TrpD.
    InterProi IPR005940. Anthranilate_Pribosyl_Tfrase.
    IPR000312. Glycosyl_Trfase_fam3.
    IPR017459. Glycosyl_Trfase_fam3_N_dom.
    [Graphical view ]
    Pfami PF02885. Glycos_trans_3N. 1 hit.
    PF00591. Glycos_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47648. SSF47648. 1 hit.
    SSF52418. SSF52418. 1 hit.
    TIGRFAMsi TIGR01245. trpD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiTRPD_BRUA2
    AccessioniPrimary (citable) accession number: Q2YRR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3