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Q2YRR5

- TRPD_BRUA2

UniProt

Q2YRR5 - TRPD_BRUA2

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Protein
Anthranilate phosphoribosyltransferase
Gene
trpD, BAB1_1163
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) By similarity.UniRule annotation

Catalytic activityi

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 2 magnesium ions per monomer By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei81 – 811Anthranilate 1; via carbonyl oxygen By similarity
Binding sitei81 – 811Phosphoribosylpyrophosphate; via amide nitrogen By similarity
Binding sitei89 – 891Phosphoribosylpyrophosphate By similarity
Metal bindingi93 – 931Magnesium 1 By similarity
Binding sitei112 – 1121Anthranilate 1 By similarity
Binding sitei121 – 1211Phosphoribosylpyrophosphate; via amide nitrogen By similarity
Binding sitei167 – 1671Anthranilate 2 By similarity
Metal bindingi225 – 2251Magnesium 2 By similarity
Metal bindingi226 – 2261Magnesium 1 By similarity
Metal bindingi226 – 2261Magnesium 2 By similarity

GO - Molecular functioni

  1. anthranilate phosphoribosyltransferase activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1185-MONOMER.
BMEL359391:GJOQ-1185-MONOMER.
UniPathwayiUPA00035; UER00041.

Names & Taxonomyi

Protein namesi
Recommended name:
Anthranilate phosphoribosyltransferase (EC:2.4.2.18)
Gene namesi
Name:trpD
Ordered Locus Names:BAB1_1163
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Anthranilate phosphoribosyltransferaseUniRule annotation
PRO_0000227140Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1163.

Structurei

3D structure databases

ProteinModelPortaliQ2YRR5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 852Phosphoribosylpyrophosphate binding By similarity
Regioni91 – 944Phosphoribosylpyrophosphate binding By similarity
Regioni109 – 1179Phosphoribosylpyrophosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0547.
HOGENOMiHOG000230451.
KOiK00766.
OMAiQPFPRPD.
OrthoDBiEOG6D5G6B.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
HAMAPiMF_00211. TrpD.
InterProiIPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view]
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsiTIGR01245. trpD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YRR5-1 [UniParc]FASTAAdd to Basket

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MADLKPYIAK AASGEPLPLG DAKAAFDIMM SGQATPSQIG GFLMALRVRG    50
ETVPEIAGAV ASMRSRMIPV IAPDDAMDIV GTGGDQSGSY NVSSCTAFVV 100
AGAGVPVAKH GNRALSSRSG AADALAALGI NIEADADTIG RSISEAGLGF 150
MFAPMHHSAM RHVGPSRVEL GTRTIFNLLG PLSNPASVKR QLVGVFAPQW 200
LEPLAHVLKE LGSETAWVVY GDGLDEMTTA GTTQVAALEN GQIRTFEITP 250
EEVGLRRCSP AELKGGEAAE NAKALLGVLE GKDSAYRDIV LLNSGAALVV 300
AGKAENLKDG IAQAVQSIDS GAALAVLQKV IAVSNDKPA 339
Length:339
Mass (Da):34,839
Last modified:February 7, 2006 - v1
Checksum:i182891532AE4FCDA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11119.1.
RefSeqiYP_414554.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11119; CAJ11119; BAB1_1163.
GeneIDi3787802.
KEGGibmf:BAB1_1163.
PATRICi17845281. VBIBruMel86222_1210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11119.1 .
RefSeqi YP_414554.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YRR5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1163.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11119 ; CAJ11119 ; BAB1_1163 .
GeneIDi 3787802.
KEGGi bmf:BAB1_1163.
PATRICi 17845281. VBIBruMel86222_1210.

Phylogenomic databases

eggNOGi COG0547.
HOGENOMi HOG000230451.
KOi K00766.
OMAi QPFPRPD.
OrthoDBi EOG6D5G6B.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00041 .
BioCyci BABO359391:GKDV-1185-MONOMER.
BMEL359391:GJOQ-1185-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
HAMAPi MF_00211. TrpD.
InterProi IPR005940. Anthranilate_Pribosyl_Tfrase.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
[Graphical view ]
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
TIGRFAMsi TIGR01245. trpD. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiTRPD_BRUA2
AccessioniPrimary (citable) accession number: Q2YRR5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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