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Q2YRN8 (GREA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription elongation factor GreA
Alternative name(s):
Transcript cleavage factor GreA
Gene names
Name:greA
Ordered Locus Names:BAB1_1523
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides By similarity. HAMAP-Rule MF_00105

Sequence similarities

Belongs to the GreA/GreB family.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   LigandDNA-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processregulation of DNA-templated transcription, elongation

Inferred from electronic annotation. Source: InterPro

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 157157Transcription elongation factor GreA HAMAP-Rule MF_00105
PRO_1000075865

Sequences

Sequence LengthMass (Da)Tools
Q2YRN8 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 5651BAFED6942B3F

FASTA15717,529
        10         20         30         40         50         60 
MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA AKEAQSLNEG 

        70         80         90        100        110        120 
RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE EKIYQIVGDQ EADVKEGRIS 

       130        140        150 
ISSPIARALI GKGEGDTIEV NAPGGSRSYE IIALKFV 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11479.1.
RefSeqYP_414889.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YRN8.
SMRQ2YRN8. Positions 2-157.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1523.

Proteomic databases

PRIDEQ2YRN8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11479; CAJ11479; BAB1_1523.
GeneID3788738.
KEGGbmf:BAB1_1523.
PATRIC17846037. VBIBruMel86222_1580.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0782.
HOGENOMHOG000241145.
KOK03624.
OMAHAQIIDV.
OrthoDBEOG686NQ9.

Enzyme and pathway databases

BioCycBABO359391:GKDV-1556-MONOMER.
BMEL359391:GJOQ-1556-MONOMER.

Family and domain databases

Gene3D1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPMF_00105. GreA_GreB.
InterProIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFPIRSF006092. GreA_GreB. 1 hit.
SUPFAMSSF46557. SSF46557. 1 hit.
TIGRFAMsTIGR01462. greA. 1 hit.
PROSITEPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGREA_BRUA2
AccessionPrimary (citable) accession number: Q2YRN8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names