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Q2YRN8

- GREA_BRUA2

UniProt

Q2YRN8 - GREA_BRUA2

Protein

Transcription elongation factor GreA

Gene

greA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of DNA-templated transcription, elongation Source: InterPro
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1556-MONOMER.
    BMEL359391:GJOQ-1556-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription elongation factor GreAUniRule annotation
    Alternative name(s):
    Transcript cleavage factor GreAUniRule annotation
    Gene namesi
    Name:greAUniRule annotation
    Ordered Locus Names:BAB1_1523
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 157157Transcription elongation factor GreAPRO_1000075865Add
    BLAST

    Proteomic databases

    PRIDEiQ2YRN8.

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_1523.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YRN8.
    SMRiQ2YRN8. Positions 2-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GreA/GreB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0782.
    HOGENOMiHOG000241145.
    KOiK03624.
    OMAiHAQIIDV.
    OrthoDBiEOG686NQ9.

    Family and domain databases

    Gene3Di1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPiMF_00105. GreA_GreB.
    InterProiIPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view]
    PfamiPF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006092. GreA_GreB. 1 hit.
    SUPFAMiSSF46557. SSF46557. 1 hit.
    TIGRFAMsiTIGR01462. greA. 1 hit.
    PROSITEiPS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2YRN8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA    50
    AKEAQSLNEG RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE 100
    EKIYQIVGDQ EADVKEGRIS ISSPIARALI GKGEGDTIEV NAPGGSRSYE 150
    IIALKFV 157
    Length:157
    Mass (Da):17,529
    Last modified:February 7, 2006 - v1
    Checksum:i5651BAFED6942B3F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11479.1.
    RefSeqiYP_414889.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11479; CAJ11479; BAB1_1523.
    GeneIDi3788738.
    KEGGibmf:BAB1_1523.
    PATRICi17846037. VBIBruMel86222_1580.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11479.1 .
    RefSeqi YP_414889.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YRN8.
    SMRi Q2YRN8. Positions 2-157.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1523.

    Proteomic databases

    PRIDEi Q2YRN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11479 ; CAJ11479 ; BAB1_1523 .
    GeneIDi 3788738.
    KEGGi bmf:BAB1_1523.
    PATRICi 17846037. VBIBruMel86222_1580.

    Phylogenomic databases

    eggNOGi COG0782.
    HOGENOMi HOG000241145.
    KOi K03624.
    OMAi HAQIIDV.
    OrthoDBi EOG686NQ9.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1556-MONOMER.
    BMEL359391:GJOQ-1556-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.180. 1 hit.
    3.10.50.30. 1 hit.
    HAMAPi MF_00105. GreA_GreB.
    InterProi IPR018151. TF_GreA/GreB_CS.
    IPR006359. Tscrpt_elong_fac_GreA.
    IPR028624. Tscrpt_elong_fac_GreA/B.
    IPR001437. Tscrpt_elong_fac_GreA/B_C.
    IPR023459. Tscrpt_elong_fac_GreA/B_fam.
    IPR022691. Tscrpt_elong_fac_GreA/B_N.
    [Graphical view ]
    Pfami PF01272. GreA_GreB. 1 hit.
    PF03449. GreA_GreB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006092. GreA_GreB. 1 hit.
    SUPFAMi SSF46557. SSF46557. 1 hit.
    TIGRFAMsi TIGR01462. greA. 1 hit.
    PROSITEi PS00829. GREAB_1. 1 hit.
    PS00830. GREAB_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiGREA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YRN8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3