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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:BAB1_1523
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000758651 – 157Transcription elongation factor GreAAdd BLAST157

Proteomic databases

PRIDEiQ2YRN8

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ2YRN8
SMRiQ2YRN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000241145
KOiK03624
OMAiTWLTQEA

Family and domain databases

Gene3Di1.10.287.180, 1 hit
3.10.50.30, 1 hit
HAMAPiMF_00105 GreA_GreB, 1 hit
InterProiView protein in InterPro
IPR036953 GreA/GreB_C_sf
IPR018151 TF_GreA/GreB_CS
IPR006359 Tscrpt_elong_fac_GreA
IPR028624 Tscrpt_elong_fac_GreA/B
IPR001437 Tscrpt_elong_fac_GreA/B_C
IPR023459 Tscrpt_elong_fac_GreA/B_fam
IPR022691 Tscrpt_elong_fac_GreA/B_N
IPR036805 Tscrpt_elong_fac_GreA/B_N_sf
PANTHERiPTHR30437 PTHR30437, 1 hit
PfamiView protein in Pfam
PF01272 GreA_GreB, 1 hit
PF03449 GreA_GreB_N, 1 hit
PIRSFiPIRSF006092 GreA_GreB, 1 hit
SUPFAMiSSF46557 SSF46557, 1 hit
TIGRFAMsiTIGR01462 greA, 1 hit
PROSITEiView protein in PROSITE
PS00829 GREAB_1, 1 hit
PS00830 GREAB_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2YRN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA
60 70 80 90 100
AKEAQSLNEG RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE
110 120 130 140 150
EKIYQIVGDQ EADVKEGRIS ISSPIARALI GKGEGDTIEV NAPGGSRSYE

IIALKFV
Length:157
Mass (Da):17,529
Last modified:February 7, 2006 - v1
Checksum:i5651BAFED6942B3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA Translation: CAJ11479.1
RefSeqiWP_002964610.1, NZ_KN046823.1

Genome annotation databases

EnsemblBacteriaiCAJ11479; CAJ11479; BAB1_1523
GeneIDi29593299
KEGGibmf:BAB1_1523
PATRICifig|359391.11.peg.969

Similar proteinsi

Entry informationi

Entry nameiGREA_BRUA2
AccessioniPrimary (citable) accession number: Q2YRN8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: April 25, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health