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Q2YRN8

- GREA_BRUA2

UniProt

Q2YRN8 - GREA_BRUA2

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Protein

Transcription elongation factor GreA

Gene

greA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.UniRule annotation

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of DNA-templated transcription, elongation Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1556-MONOMER.
BMEL359391:GJOQ-1556-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor GreAUniRule annotation
Alternative name(s):
Transcript cleavage factor GreAUniRule annotation
Gene namesi
Name:greAUniRule annotation
Ordered Locus Names:BAB1_1523
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 157157Transcription elongation factor GreAPRO_1000075865Add
BLAST

Proteomic databases

PRIDEiQ2YRN8.

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_1523.

Structurei

3D structure databases

ProteinModelPortaliQ2YRN8.
SMRiQ2YRN8. Positions 2-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GreA/GreB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0782.
HOGENOMiHOG000241145.
KOiK03624.
OMAiHAQIIDV.
OrthoDBiEOG686NQ9.

Family and domain databases

Gene3Di1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPiMF_00105. GreA_GreB.
InterProiIPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view]
PfamiPF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF006092. GreA_GreB. 1 hit.
SUPFAMiSSF46557. SSF46557. 1 hit.
TIGRFAMsiTIGR01462. greA. 1 hit.
PROSITEiPS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2YRN8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKFPMTPRG FEKLKEELRW RQQSERPRII EAIAEARAHG DLSENAEYHA
60 70 80 90 100
AKEAQSLNEG RINELEDLVA RAEVIDVSKL TGDRIKFGAT VTMIDEDTEE
110 120 130 140 150
EKIYQIVGDQ EADVKEGRIS ISSPIARALI GKGEGDTIEV NAPGGSRSYE

IIALKFV
Length:157
Mass (Da):17,529
Last modified:February 7, 2006 - v1
Checksum:i5651BAFED6942B3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11479.1.
RefSeqiYP_414889.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11479; CAJ11479; BAB1_1523.
GeneIDi3788738.
KEGGibmf:BAB1_1523.
PATRICi17846037. VBIBruMel86222_1580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11479.1 .
RefSeqi YP_414889.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YRN8.
SMRi Q2YRN8. Positions 2-157.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1523.

Proteomic databases

PRIDEi Q2YRN8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11479 ; CAJ11479 ; BAB1_1523 .
GeneIDi 3788738.
KEGGi bmf:BAB1_1523.
PATRICi 17846037. VBIBruMel86222_1580.

Phylogenomic databases

eggNOGi COG0782.
HOGENOMi HOG000241145.
KOi K03624.
OMAi HAQIIDV.
OrthoDBi EOG686NQ9.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1556-MONOMER.
BMEL359391:GJOQ-1556-MONOMER.

Family and domain databases

Gene3Di 1.10.287.180. 1 hit.
3.10.50.30. 1 hit.
HAMAPi MF_00105. GreA_GreB.
InterProi IPR018151. TF_GreA/GreB_CS.
IPR006359. Tscrpt_elong_fac_GreA.
IPR028624. Tscrpt_elong_fac_GreA/B.
IPR001437. Tscrpt_elong_fac_GreA/B_C.
IPR023459. Tscrpt_elong_fac_GreA/B_fam.
IPR022691. Tscrpt_elong_fac_GreA/B_N.
[Graphical view ]
Pfami PF01272. GreA_GreB. 1 hit.
PF03449. GreA_GreB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF006092. GreA_GreB. 1 hit.
SUPFAMi SSF46557. SSF46557. 1 hit.
TIGRFAMsi TIGR01462. greA. 1 hit.
PROSITEi PS00829. GREAB_1. 1 hit.
PS00830. GREAB_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiGREA_BRUA2
AccessioniPrimary (citable) accession number: Q2YRN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 7, 2006
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3