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Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1757-MONOMER.
BMEL359391:GJOQ-1757-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvBUniRule annotation
Ordered Locus Names:BAB1_1714
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Holliday junction ATP-dependent DNA helicase RuvBPRO_0000235352Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvA.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ2YRD2.
SMRiQ2YRD2. Positions 19-330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2255.
HOGENOMiHOG000218623.
KOiK03551.
OMAiYEPYLMQ.
OrthoDBiEOG6SR93S.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00016. DNA_helic_RuvB.
InterProiIPR003593. AAA+_ATPase.
IPR000641. CbxX_CfqX.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSiPR00819. CBXCFQXSUPER.
ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00635. ruvB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YRD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRNPLIDA DRRADEDNTL RPQTLDDFVG QAAARANLKV FIEAAKVRGE
60 70 80 90 100
ALDHVLFVGP PGLGKTTLAQ IMAKELGVNF RSTSGPVIAK AGDLAALLTN
110 120 130 140 150
LEERDVLFID EIHRLSPAVE EILYPAMEDF QLDLIIGEGP AARSVKIDLA
160 170 180 190 200
KFTLVAATTR LGLLTTPLRD RFGIPVRLNF YTVEELEYIV RRGARIMQMG
210 220 230 240 250
ISSDGAREVA RRSRGTPRIA GRLLRRVRDF ALVAGADIID RRIADEALSR
260 270 280 290 300
LEVDNRGLDQ LDRRYLNIIA RNFGGGPVGI ETIAAGLSEP RDAIEDIIEP
310 320 330 340
YLIQQGFLQR TPRGRVLTAV AWQHLGLPAP AEIIQQSQYG LFMEDE
Length:346
Mass (Da):38,241
Last modified:February 7, 2006 - v1
Checksum:iE6671068908197AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11670.1.
RefSeqiWP_002964791.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11670; CAJ11670; BAB1_1714.
GeneIDi3788959.
KEGGibmf:BAB1_1714.
PATRICi17846455. VBIBruMel86222_1777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11670.1.
RefSeqiWP_002964791.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YRD2.
SMRiQ2YRD2. Positions 19-330.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11670; CAJ11670; BAB1_1714.
GeneIDi3788959.
KEGGibmf:BAB1_1714.
PATRICi17846455. VBIBruMel86222_1777.

Phylogenomic databases

eggNOGiCOG2255.
HOGENOMiHOG000218623.
KOiK03551.
OMAiYEPYLMQ.
OrthoDBiEOG6SR93S.

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1757-MONOMER.
BMEL359391:GJOQ-1757-MONOMER.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00016. DNA_helic_RuvB.
InterProiIPR003593. AAA+_ATPase.
IPR000641. CbxX_CfqX.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSiPR00819. CBXCFQXSUPER.
ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00635. ruvB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiRUVB_BRUA2
AccessioniPrimary (citable) accession number: Q2YRD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 7, 2006
Last modified: July 22, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.