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Q2YRD2

- RUVB_BRUA2

UniProt

Q2YRD2 - RUVB_BRUA2

Protein

Holliday junction ATP-dependent DNA helicase RuvB

Gene

ruvB

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi59 – 668ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. four-way junction helicase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-HAMAP
    2. DNA repair Source: UniProtKB-HAMAP
    3. SOS response Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1757-MONOMER.
    BMEL359391:GJOQ-1757-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvBUniRule annotation
    Ordered Locus Names:BAB1_1714
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Holliday junction ATP-dependent DNA helicase RuvBPRO_0000235352Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvA.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1714.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YRD2.
    SMRiQ2YRD2. Positions 19-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2255.
    HOGENOMiHOG000218623.
    KOiK03551.
    OMAiDYAEVKH.
    OrthoDBiEOG6SR93S.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00016. DNA_helic_RuvB.
    InterProiIPR003593. AAA+_ATPase.
    IPR000641. CbxX_CfqX.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view]
    PRINTSiPR00819. CBXCFQXSUPER.
    ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00635. ruvB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YRD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRNPLIDA DRRADEDNTL RPQTLDDFVG QAAARANLKV FIEAAKVRGE    50
    ALDHVLFVGP PGLGKTTLAQ IMAKELGVNF RSTSGPVIAK AGDLAALLTN 100
    LEERDVLFID EIHRLSPAVE EILYPAMEDF QLDLIIGEGP AARSVKIDLA 150
    KFTLVAATTR LGLLTTPLRD RFGIPVRLNF YTVEELEYIV RRGARIMQMG 200
    ISSDGAREVA RRSRGTPRIA GRLLRRVRDF ALVAGADIID RRIADEALSR 250
    LEVDNRGLDQ LDRRYLNIIA RNFGGGPVGI ETIAAGLSEP RDAIEDIIEP 300
    YLIQQGFLQR TPRGRVLTAV AWQHLGLPAP AEIIQQSQYG LFMEDE 346
    Length:346
    Mass (Da):38,241
    Last modified:February 7, 2006 - v1
    Checksum:iE6671068908197AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11670.1.
    RefSeqiYP_415064.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11670; CAJ11670; BAB1_1714.
    GeneIDi3788959.
    KEGGibmf:BAB1_1714.
    PATRICi17846455. VBIBruMel86222_1777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11670.1 .
    RefSeqi YP_415064.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YRD2.
    SMRi Q2YRD2. Positions 19-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1714.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11670 ; CAJ11670 ; BAB1_1714 .
    GeneIDi 3788959.
    KEGGi bmf:BAB1_1714.
    PATRICi 17846455. VBIBruMel86222_1777.

    Phylogenomic databases

    eggNOGi COG2255.
    HOGENOMi HOG000218623.
    KOi K03551.
    OMAi DYAEVKH.
    OrthoDBi EOG6SR93S.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1757-MONOMER.
    BMEL359391:GJOQ-1757-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00016. DNA_helic_RuvB.
    InterProi IPR003593. AAA+_ATPase.
    IPR000641. CbxX_CfqX.
    IPR004605. DNA_helicase_Holl-junc_RuvB.
    IPR008823. DNA_helicase_Holl-junc_RuvB_C.
    IPR008824. DNA_helicase_Holl-junc_RuvB_N.
    IPR027417. P-loop_NTPase.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF05491. RuvB_C. 1 hit.
    PF05496. RuvB_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00819. CBXCFQXSUPER.
    ProDomi PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00635. ruvB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiRUVB_BRUA2
    AccessioniPrimary (citable) accession number: Q2YRD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3