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Q2YRD2

- RUVB_BRUA2

UniProt

Q2YRD2 - RUVB_BRUA2

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Protein
Holliday junction ATP-dependent DNA helicase RuvB
Gene
ruvB, BAB1_1714
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing By similarity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi59 – 668ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. four-way junction helicase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
  3. SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1757-MONOMER.
BMEL359391:GJOQ-1757-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvB (EC:3.6.4.12)
Gene namesi
Name:ruvB
Ordered Locus Names:BAB1_1714
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Holliday junction ATP-dependent DNA helicase RuvBUniRule annotation
PRO_0000235352Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvA By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1714.

Structurei

3D structure databases

ProteinModelPortaliQ2YRD2.
SMRiQ2YRD2. Positions 19-330.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvB family.

Phylogenomic databases

eggNOGiCOG2255.
HOGENOMiHOG000218623.
KOiK03551.
OMAiDYAEVKH.
OrthoDBiEOG6SR93S.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00016. DNA_helic_RuvB.
InterProiIPR003593. AAA+_ATPase.
IPR000641. CbxX_CfqX.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view]
PRINTSiPR00819. CBXCFQXSUPER.
ProDomiPD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00635. ruvB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YRD2-1 [UniParc]FASTAAdd to Basket

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MSDRNPLIDA DRRADEDNTL RPQTLDDFVG QAAARANLKV FIEAAKVRGE    50
ALDHVLFVGP PGLGKTTLAQ IMAKELGVNF RSTSGPVIAK AGDLAALLTN 100
LEERDVLFID EIHRLSPAVE EILYPAMEDF QLDLIIGEGP AARSVKIDLA 150
KFTLVAATTR LGLLTTPLRD RFGIPVRLNF YTVEELEYIV RRGARIMQMG 200
ISSDGAREVA RRSRGTPRIA GRLLRRVRDF ALVAGADIID RRIADEALSR 250
LEVDNRGLDQ LDRRYLNIIA RNFGGGPVGI ETIAAGLSEP RDAIEDIIEP 300
YLIQQGFLQR TPRGRVLTAV AWQHLGLPAP AEIIQQSQYG LFMEDE 346
Length:346
Mass (Da):38,241
Last modified:February 7, 2006 - v1
Checksum:iE6671068908197AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11670.1.
RefSeqiYP_415064.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11670; CAJ11670; BAB1_1714.
GeneIDi3788959.
KEGGibmf:BAB1_1714.
PATRICi17846455. VBIBruMel86222_1777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11670.1 .
RefSeqi YP_415064.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YRD2.
SMRi Q2YRD2. Positions 19-330.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11670 ; CAJ11670 ; BAB1_1714 .
GeneIDi 3788959.
KEGGi bmf:BAB1_1714.
PATRICi 17846455. VBIBruMel86222_1777.

Phylogenomic databases

eggNOGi COG2255.
HOGENOMi HOG000218623.
KOi K03551.
OMAi DYAEVKH.
OrthoDBi EOG6SR93S.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1757-MONOMER.
BMEL359391:GJOQ-1757-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00016. DNA_helic_RuvB.
InterProi IPR003593. AAA+_ATPase.
IPR000641. CbxX_CfqX.
IPR004605. DNA_helicase_Holl-junc_RuvB.
IPR008823. DNA_helicase_Holl-junc_RuvB_C.
IPR008824. DNA_helicase_Holl-junc_RuvB_N.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF05491. RuvB_C. 1 hit.
PF05496. RuvB_N. 1 hit.
[Graphical view ]
PRINTSi PR00819. CBXCFQXSUPER.
ProDomi PD005323. DNA_helicase_Holl-junc_RuvB_C. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00635. ruvB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiRUVB_BRUA2
AccessioniPrimary (citable) accession number: Q2YRD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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