Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q2YRD1 (RUVA_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Holliday junction ATP-dependent DNA helicase RuvA

EC=3.6.4.12
Gene names
Name:ruvA
Ordered Locus Names:BAB1_1715
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity. HAMAP-Rule MF_00031

Catalytic activity

ATP + H2O = ADP + phosphate. HAMAP-Rule MF_00031

Subunit structure

Forms a complex with RuvB By similarity. HAMAP-Rule MF_00031

Sequence similarities

Belongs to the RuvA family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Holliday junction ATP-dependent DNA helicase RuvA HAMAP-Rule MF_00031
PRO_1000002406

Sequences

Sequence LengthMass (Da)Tools
Q2YRD1 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 6BC6165956AAAF25

FASTA20521,227
        10         20         30         40         50         60 
MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE TYVREDMIRL 

        70         80         90        100        110        120 
YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN AIALRDIAMV SRAPGVGKKV 

       130        140        150        160        170        180 
AERIVTELKN KAPAFAGEAS GTIGLKQELG AGAAPAPVAD AVSALSNLGY SRDQAANAVA 

       190        200 
AALKETGEGA DSAKLIRLGL KELSQ 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11671.1.
RefSeqYP_415065.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YRD1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1715.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11671; CAJ11671; BAB1_1715.
GeneID3788958.
KEGGbmf:BAB1_1715.
PATRIC17846457. VBIBruMel86222_1778.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0632.
HOGENOMHOG000057115.
KOK03550.
OMAVGYQVHC.
OrthoDBEOG679THG.
ProtClustDBPRK00116.

Enzyme and pathway databases

BioCycBABO359391:GKDV-1758-MONOMER.
BMEL359391:GJOQ-1758-MONOMER.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_00031. DNA_helic_RuvA.
InterProIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00084. ruvA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVA_BRUA2
AccessionPrimary (citable) accession number: Q2YRD1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: April 16, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names