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Q2YRD1

- RUVA_BRUA2

UniProt

Q2YRD1 - RUVA_BRUA2

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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene
ruvA, BAB1_1715
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB By similarity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. four-way junction helicase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. SOS response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBABO359391:GKDV-1758-MONOMER.
BMEL359391:GJOQ-1758-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvA (EC:3.6.4.12)
Gene namesi
Name:ruvA
Ordered Locus Names:BAB1_1715
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. Holliday junction helicase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Holliday junction ATP-dependent DNA helicase RuvAUniRule annotationPRO_1000002406Add
BLAST

Interactioni

Subunit structurei

Forms a complex with RuvB By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi359391.BAB1_1715.

Structurei

3D structure databases

ProteinModelPortaliQ2YRD1.

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.

Phylogenomic databases

eggNOGiCOG0632.
HOGENOMiHOG000057115.
KOiK03550.
OMAiGYKPQQA.
OrthoDBiEOG679THG.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YRD1-1 [UniParc]FASTAAdd to Basket

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MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE    50
TYVREDMIRL YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN 100
AIALRDIAMV SRAPGVGKKV AERIVTELKN KAPAFAGEAS GTIGLKQELG 150
AGAAPAPVAD AVSALSNLGY SRDQAANAVA AALKETGEGA DSAKLIRLGL 200
KELSQ 205
Length:205
Mass (Da):21,227
Last modified:February 7, 2006 - v1
Checksum:i6BC6165956AAAF25
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11671.1.
RefSeqiYP_415065.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11671; CAJ11671; BAB1_1715.
GeneIDi3788958.
KEGGibmf:BAB1_1715.
PATRICi17846457. VBIBruMel86222_1778.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11671.1 .
RefSeqi YP_415065.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YRD1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1715.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11671 ; CAJ11671 ; BAB1_1715 .
GeneIDi 3788958.
KEGGi bmf:BAB1_1715.
PATRICi 17846457. VBIBruMel86222_1778.

Phylogenomic databases

eggNOGi COG0632.
HOGENOMi HOG000057115.
KOi K03550.
OMAi GYKPQQA.
OrthoDBi EOG679THG.

Enzyme and pathway databases

BioCyci BABO359391:GKDV-1758-MONOMER.
BMEL359391:GJOQ-1758-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00031. DNA_helic_RuvA.
InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view ]
Pfami PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view ]
SMARTi SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00084. ruvA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiRUVA_BRUA2
AccessioniPrimary (citable) accession number: Q2YRD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi