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Q2YRD1

- RUVA_BRUA2

UniProt

Q2YRD1 - RUVA_BRUA2

Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. four-way junction helicase activity Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. SOS response Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombination, DNA repair, SOS response

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-1758-MONOMER.
    BMEL359391:GJOQ-1758-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvAUniRule annotation
    Ordered Locus Names:BAB1_1715
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. Holliday junction helicase complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 205205Holliday junction ATP-dependent DNA helicase RuvAPRO_1000002406Add
    BLAST

    Interactioni

    Subunit structurei

    Forms a complex with RuvB.UniRule annotation

    Protein-protein interaction databases

    STRINGi359391.BAB1_1715.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YRD1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0632.
    HOGENOMiHOG000057115.
    KOiK03550.
    OMAiGYKPQQA.
    OrthoDBiEOG679THG.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00031. DNA_helic_RuvA.
    InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PfamiPF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view]
    SMARTiSM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00084. ruvA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YRD1-1 [UniParc]FASTAAdd to Basket

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    MIGKLKGVID EIAEDHAVID VHGVGYVAFC SARTLGNLGG AGEAAILFIE    50
    TYVREDMIRL YGFATQLERE WFRLLQNVQG VGAKVALAVL GTLSPSELAN 100
    AIALRDIAMV SRAPGVGKKV AERIVTELKN KAPAFAGEAS GTIGLKQELG 150
    AGAAPAPVAD AVSALSNLGY SRDQAANAVA AALKETGEGA DSAKLIRLGL 200
    KELSQ 205
    Length:205
    Mass (Da):21,227
    Last modified:February 7, 2006 - v1
    Checksum:i6BC6165956AAAF25
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11671.1.
    RefSeqiYP_415065.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11671; CAJ11671; BAB1_1715.
    GeneIDi3788958.
    KEGGibmf:BAB1_1715.
    PATRICi17846457. VBIBruMel86222_1778.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11671.1 .
    RefSeqi YP_415065.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YRD1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1715.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11671 ; CAJ11671 ; BAB1_1715 .
    GeneIDi 3788958.
    KEGGi bmf:BAB1_1715.
    PATRICi 17846457. VBIBruMel86222_1778.

    Phylogenomic databases

    eggNOGi COG0632.
    HOGENOMi HOG000057115.
    KOi K03550.
    OMAi GYKPQQA.
    OrthoDBi EOG679THG.

    Enzyme and pathway databases

    BioCyci BABO359391:GKDV-1758-MONOMER.
    BMEL359391:GJOQ-1758-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00031. DNA_helic_RuvA.
    InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    Pfami PF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00084. ruvA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiRUVA_BRUA2
    AccessioniPrimary (citable) accession number: Q2YRD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3