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Q2YR96

- QUEC_BRUA2

UniProt

Q2YR96 - QUEC_BRUA2

Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (07 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

    Catalytic activityi

    7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi185 – 1851ZincUniRule annotation
    Metal bindingi193 – 1931ZincUniRule annotation
    Metal bindingi196 – 1961ZincUniRule annotation
    Metal bindingi199 – 1991ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 1711ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. queuosine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Queuosine biosynthesis

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciBABO359391:GKDV-2025-MONOMER.
    BMEL359391:GJOQ-2025-MONOMER.
    UniPathwayiUPA00391.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
    Alternative name(s):
    7-cyano-7-carbaguanine synthaseUniRule annotation
    PreQ(0) synthaseUniRule annotation
    Queuosine biosynthesis protein QueCUniRule annotation
    Gene namesi
    Name:queCUniRule annotation
    Ordered Locus Names:BAB1_1973
    OrganismiBrucella abortus (strain 2308)
    Taxonomic identifieri359391 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000002719: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2322327-cyano-7-deazaguanine synthasePRO_0000246814Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359391.BAB1_1973.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2YR96.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the QueC family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0603.
    HOGENOMiHOG000110564.
    KOiK06920.
    OMAiCLSCIAR.
    OrthoDBiEOG6091HB.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_01633. QueC.
    InterProiIPR018317. QueC.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF06508. QueC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006293. ExsB. 1 hit.
    TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2YR96-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLVICSGG LDSVSLAHKM AAEHELTGLL SFDYGQRHKK ELDFAQACAK    50
    RLGVPHQIID IRTIGASLTG SALTDDVDVP DGHYAEETMK VTVVPNRNAI 100
    MLAIAFGVAA AQKADAVALA VHGGDHFIYP DCRPGFIEAF QTMQKHALDG 150
    YADVKLLAPY VHATKADIVA DGAKYRTPFE ATWSCYKGAD RHCGRCGTCV 200
    ERREAFHLAG IDDPTSYEDA DFWRATTQKR NA 232
    Length:232
    Mass (Da):25,256
    Last modified:February 7, 2006 - v1
    Checksum:i0309DDFBB3468597
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11929.1.
    RefSeqiYP_415306.1. NC_007618.1.

    Genome annotation databases

    EnsemblBacteriaiCAJ11929; CAJ11929; BAB1_1973.
    GeneIDi3788434.
    KEGGibmf:BAB1_1973.
    PATRICi17847033. VBIBruMel86222_2055.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM040264 Genomic DNA. Translation: CAJ11929.1 .
    RefSeqi YP_415306.1. NC_007618.1.

    3D structure databases

    ProteinModelPortali Q2YR96.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359391.BAB1_1973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAJ11929 ; CAJ11929 ; BAB1_1973 .
    GeneIDi 3788434.
    KEGGi bmf:BAB1_1973.
    PATRICi 17847033. VBIBruMel86222_2055.

    Phylogenomic databases

    eggNOGi COG0603.
    HOGENOMi HOG000110564.
    KOi K06920.
    OMAi CLSCIAR.
    OrthoDBi EOG6091HB.

    Enzyme and pathway databases

    UniPathwayi UPA00391 .
    BioCyci BABO359391:GKDV-2025-MONOMER.
    BMEL359391:GJOQ-2025-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_01633. QueC.
    InterProi IPR018317. QueC.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF06508. QueC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006293. ExsB. 1 hit.
    TIGRFAMsi TIGR00364. TIGR00364. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 2308.

    Entry informationi

    Entry nameiQUEC_BRUA2
    AccessioniPrimary (citable) accession number: Q2YR96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: February 7, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Brucella abortus strain 2308
      Brucella abortus (strain 2308): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3