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Q2YR96

- QUEC_BRUA2

UniProt

Q2YR96 - QUEC_BRUA2

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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi185 – 1851ZincUniRule annotation
Metal bindingi193 – 1931ZincUniRule annotation
Metal bindingi196 – 1961ZincUniRule annotation
Metal bindingi199 – 1991ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 1711ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2025-MONOMER.
BMEL359391:GJOQ-2025-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
PreQ(0) synthaseUniRule annotation
Queuosine biosynthesis protein QueCUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:BAB1_1973
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2322327-cyano-7-deazaguanine synthasePRO_0000246814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_1973.

Structurei

3D structure databases

ProteinModelPortaliQ2YR96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0603.
HOGENOMiHOG000110564.
KOiK06920.
OMAiCLSCIAR.
OrthoDBiEOG6091HB.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YR96-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKTLVICSGG LDSVSLAHKM AAEHELTGLL SFDYGQRHKK ELDFAQACAK
60 70 80 90 100
RLGVPHQIID IRTIGASLTG SALTDDVDVP DGHYAEETMK VTVVPNRNAI
110 120 130 140 150
MLAIAFGVAA AQKADAVALA VHGGDHFIYP DCRPGFIEAF QTMQKHALDG
160 170 180 190 200
YADVKLLAPY VHATKADIVA DGAKYRTPFE ATWSCYKGAD RHCGRCGTCV
210 220 230
ERREAFHLAG IDDPTSYEDA DFWRATTQKR NA
Length:232
Mass (Da):25,256
Last modified:February 7, 2006 - v1
Checksum:i0309DDFBB3468597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1.
RefSeqiYP_415306.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11929; CAJ11929; BAB1_1973.
GeneIDi3788434.
KEGGibmf:BAB1_1973.
PATRICi17847033. VBIBruMel86222_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1 .
RefSeqi YP_415306.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YR96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11929 ; CAJ11929 ; BAB1_1973 .
GeneIDi 3788434.
KEGGi bmf:BAB1_1973.
PATRICi 17847033. VBIBruMel86222_2055.

Phylogenomic databases

eggNOGi COG0603.
HOGENOMi HOG000110564.
KOi K06920.
OMAi CLSCIAR.
OrthoDBi EOG6091HB.

Enzyme and pathway databases

UniPathwayi UPA00391 .
BioCyci BABO359391:GKDV-2025-MONOMER.
BMEL359391:GJOQ-2025-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_01633. QueC.
InterProi IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF06508. QueC. 1 hit.
[Graphical view ]
PIRSFi PIRSF006293. ExsB. 1 hit.
TIGRFAMsi TIGR00364. TIGR00364. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiQUEC_BRUA2
AccessioniPrimary (citable) accession number: Q2YR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: November 26, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3