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Protein

7-cyano-7-deazaguanine synthase

Gene

queC

Organism
Brucella abortus (strain 2308)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0).UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: 7-cyano-7-deazaguanine biosynthesis

This protein is involved in the pathway 7-cyano-7-deazaguanine biosynthesis, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway 7-cyano-7-deazaguanine biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi185ZincUniRule annotation1
Metal bindingi193ZincUniRule annotation1
Metal bindingi196ZincUniRule annotation1
Metal bindingi199ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 17ATPUniRule annotationAdd BLAST11

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthaseUniRule annotation (EC:6.3.4.20UniRule annotation)
Alternative name(s):
7-cyano-7-carbaguanine synthaseUniRule annotation
PreQ(0) synthaseUniRule annotation
Queuosine biosynthesis protein QueCUniRule annotation
Gene namesi
Name:queCUniRule annotation
Ordered Locus Names:BAB1_1973
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000002719 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002468141 – 2327-cyano-7-deazaguanine synthaseAdd BLAST232

Structurei

3D structure databases

ProteinModelPortaliQ2YR96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000110564.
KOiK06920.
OMAiMAVSYAE.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11587:SF3. PTHR11587:SF3. 1 hit.
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YR96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLVICSGG LDSVSLAHKM AAEHELTGLL SFDYGQRHKK ELDFAQACAK
60 70 80 90 100
RLGVPHQIID IRTIGASLTG SALTDDVDVP DGHYAEETMK VTVVPNRNAI
110 120 130 140 150
MLAIAFGVAA AQKADAVALA VHGGDHFIYP DCRPGFIEAF QTMQKHALDG
160 170 180 190 200
YADVKLLAPY VHATKADIVA DGAKYRTPFE ATWSCYKGAD RHCGRCGTCV
210 220 230
ERREAFHLAG IDDPTSYEDA DFWRATTQKR NA
Length:232
Mass (Da):25,256
Last modified:February 7, 2006 - v1
Checksum:i0309DDFBB3468597
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1.
RefSeqiWP_002965038.1. NZ_KN046823.1.

Genome annotation databases

EnsemblBacteriaiCAJ11929; CAJ11929; BAB1_1973.
GeneIDi3788434.
KEGGibmf:BAB1_1973.
PATRICi17847033. VBIBruMel86222_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1.
RefSeqiWP_002965038.1. NZ_KN046823.1.

3D structure databases

ProteinModelPortaliQ2YR96.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ11929; CAJ11929; BAB1_1973.
GeneIDi3788434.
KEGGibmf:BAB1_1973.
PATRICi17847033. VBIBruMel86222_2055.

Phylogenomic databases

HOGENOMiHOG000110564.
KOiK06920.
OMAiMAVSYAE.

Enzyme and pathway databases

UniPathwayiUPA00391.

Family and domain databases

CDDicd01995. ExsB. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC. 1 hit.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR11587:SF3. PTHR11587:SF3. 1 hit.
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQUEC_BRUA2
AccessioniPrimary (citable) accession number: Q2YR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: November 2, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.