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Q2YR96 (QUEC_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
7-cyano-7-deazaguanine synthase

EC=6.3.4.20
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene names
Name:queC
Ordered Locus Names:BAB1_1973
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0) By similarity. HAMAP-Rule MF_01633

Catalytic activity

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O. HAMAP-Rule MF_01633

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01633

Pathway

Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. HAMAP-Rule MF_01633

Sequence similarities

Belongs to the QueC family.

Ontologies

Keywords
   Biological processQueuosine biosynthesis
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processqueuosine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

ligase activity, forming carbon-nitrogen bonds

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2322327-cyano-7-deazaguanine synthase HAMAP-Rule MF_01633
PRO_0000246814

Regions

Nucleotide binding7 – 1711ATP By similarity

Sites

Metal binding1851Zinc By similarity
Metal binding1931Zinc By similarity
Metal binding1961Zinc By similarity
Metal binding1991Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2YR96 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 0309DDFBB3468597

FASTA23225,256
        10         20         30         40         50         60 
MKTLVICSGG LDSVSLAHKM AAEHELTGLL SFDYGQRHKK ELDFAQACAK RLGVPHQIID 

        70         80         90        100        110        120 
IRTIGASLTG SALTDDVDVP DGHYAEETMK VTVVPNRNAI MLAIAFGVAA AQKADAVALA 

       130        140        150        160        170        180 
VHGGDHFIYP DCRPGFIEAF QTMQKHALDG YADVKLLAPY VHATKADIVA DGAKYRTPFE 

       190        200        210        220        230 
ATWSCYKGAD RHCGRCGTCV ERREAFHLAG IDDPTSYEDA DFWRATTQKR NA 

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM040264 Genomic DNA. Translation: CAJ11929.1.
RefSeqYP_415306.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YR96.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359391.BAB1_1973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAJ11929; CAJ11929; BAB1_1973.
GeneID3788434.
KEGGbmf:BAB1_1973.
PATRIC17847033. VBIBruMel86222_2055.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0603.
HOGENOMHOG000110564.
KOK06920.
OMAEKTWSCY.
OrthoDBEOG6091HB.
ProtClustDBCLSK864390.

Enzyme and pathway databases

BioCycBABO359391:GKDV-2025-MONOMER.
BMEL359391:GJOQ-2025-MONOMER.
UniPathwayUPA00391.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_01633. QueC.
InterProIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF06508. QueC. 1 hit.
[Graphical view]
PIRSFPIRSF006293. ExsB. 1 hit.
TIGRFAMsTIGR00364. TIGR00364. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQUEC_BRUA2
AccessionPrimary (citable) accession number: Q2YR96
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names