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Q2YR96

- QUEC_BRUA2

UniProt

Q2YR96 - QUEC_BRUA2

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Protein
7-cyano-7-deazaguanine synthase
Gene
queC, BAB1_1973
Organism
Brucella abortus (strain 2308)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ0) By similarity.UniRule annotation

Catalytic activityi

7-carboxy-7-carbaguanine + NH3 + ATP = 7-cyano-7-carbaguanine + ADP + phosphate + H2O.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi185 – 1851Zinc By similarity
Metal bindingi193 – 1931Zinc By similarity
Metal bindingi196 – 1961Zinc By similarity
Metal bindingi199 – 1991Zinc By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 1711ATP By similarity
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. ligase activity, forming carbon-nitrogen bonds Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. queuosine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Queuosine biosynthesis

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciBABO359391:GKDV-2025-MONOMER.
BMEL359391:GJOQ-2025-MONOMER.
UniPathwayiUPA00391.

Names & Taxonomyi

Protein namesi
Recommended name:
7-cyano-7-deazaguanine synthase (EC:6.3.4.20)
Alternative name(s):
7-cyano-7-carbaguanine synthase
PreQ(0) synthase
Queuosine biosynthesis protein QueC
Gene namesi
Name:queC
Ordered Locus Names:BAB1_1973
OrganismiBrucella abortus (strain 2308)
Taxonomic identifieri359391 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000002719: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2322327-cyano-7-deazaguanine synthaseUniRule annotation
PRO_0000246814Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi359391.BAB1_1973.

Structurei

3D structure databases

ProteinModelPortaliQ2YR96.

Family & Domainsi

Sequence similaritiesi

Belongs to the QueC family.

Phylogenomic databases

eggNOGiCOG0603.
HOGENOMiHOG000110564.
KOiK06920.
OMAiCLSCIAR.
OrthoDBiEOG6091HB.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01633. QueC.
InterProiIPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF06508. QueC. 1 hit.
[Graphical view]
PIRSFiPIRSF006293. ExsB. 1 hit.
TIGRFAMsiTIGR00364. TIGR00364. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2YR96-1 [UniParc]FASTAAdd to Basket

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MKTLVICSGG LDSVSLAHKM AAEHELTGLL SFDYGQRHKK ELDFAQACAK    50
RLGVPHQIID IRTIGASLTG SALTDDVDVP DGHYAEETMK VTVVPNRNAI 100
MLAIAFGVAA AQKADAVALA VHGGDHFIYP DCRPGFIEAF QTMQKHALDG 150
YADVKLLAPY VHATKADIVA DGAKYRTPFE ATWSCYKGAD RHCGRCGTCV 200
ERREAFHLAG IDDPTSYEDA DFWRATTQKR NA 232
Length:232
Mass (Da):25,256
Last modified:February 7, 2006 - v1
Checksum:i0309DDFBB3468597
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1.
RefSeqiYP_415306.1. NC_007618.1.

Genome annotation databases

EnsemblBacteriaiCAJ11929; CAJ11929; BAB1_1973.
GeneIDi3788434.
KEGGibmf:BAB1_1973.
PATRICi17847033. VBIBruMel86222_2055.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM040264 Genomic DNA. Translation: CAJ11929.1 .
RefSeqi YP_415306.1. NC_007618.1.

3D structure databases

ProteinModelPortali Q2YR96.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359391.BAB1_1973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ11929 ; CAJ11929 ; BAB1_1973 .
GeneIDi 3788434.
KEGGi bmf:BAB1_1973.
PATRICi 17847033. VBIBruMel86222_2055.

Phylogenomic databases

eggNOGi COG0603.
HOGENOMi HOG000110564.
KOi K06920.
OMAi CLSCIAR.
OrthoDBi EOG6091HB.

Enzyme and pathway databases

UniPathwayi UPA00391 .
BioCyci BABO359391:GKDV-2025-MONOMER.
BMEL359391:GJOQ-2025-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_01633. QueC.
InterProi IPR018317. QueC.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF06508. QueC. 1 hit.
[Graphical view ]
PIRSFi PIRSF006293. ExsB. 1 hit.
TIGRFAMsi TIGR00364. TIGR00364. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 2308.

Entry informationi

Entry nameiQUEC_BRUA2
AccessioniPrimary (citable) accession number: Q2YR96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: February 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella abortus strain 2308
    Brucella abortus (strain 2308): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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