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Q2YR43 (AROB_BRUA2) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BAB1_2029
OrganismBrucella abortus (strain 2308) [Complete proteome] [HAMAP]
Taxonomic identifier359391 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm Probable HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3783783-dehydroquinate synthase HAMAP MF_00110
PRO_0000231072

Sequences

Sequence LengthMass (Da)Tools
Q2YR43 [UniParc].

Last modified February 7, 2006. Version 1.
Checksum: 893D103F298080E6

FASTA37839,915
        10         20         30         40         50         60 
MNAPTTFADS VTVPVSLGDR SYDILIGKGL VERAGEEVAK RLKGVRVAIV TDENVAAVHL 

        70         80         90        100        110        120 
ERLQASFARA GIDSTPVIVA PGEKSKSFAT LETVTNAILV AKLERGDAVV ALGGGVVGDL 

       130        140        150        160        170        180 
SGFVAGIVRR GMNFVQMPTS LLAQVDSSVG GKTGINTAHG KNLVGVFNQP QLVLADTQVL 

       190        200        210        220        230        240 
DTLSPREFRA GYAEVAKYGL IDRPDFFAWL EANWQEVFSG GAARTKAIAE SCRSKAAVVA 

       250        260        270        280        290        300 
RDERETGDRA LLNLGHTFGH ALESATGYDS SRLVHGEGVA IGMALAYRFS ARMNLAGIEA 

       310        320        330        340        350        360 
AERVEAHLKA VGLPVSLAEV PGGLPPAEKL MDYIAQDKKV TRGTLTFILT HGIGQSFIAK 

       370 
DVPPAAVLEF LKERLAIA

« Hide

References

[1]"Whole-genome analyses of speciation events in pathogenic Brucellae."
Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A., Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.
Infect. Immun. 73:8353-8361(2005) [PubMed: 16299333] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2308.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM040264 Genomic DNA. Translation: CAJ11985.1.
RefSeqYP_415359.1. NC_007618.1.

3D structure databases

ProteinModelPortalQ2YR43.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ2YR43.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3788621.
GenomeReviewsGene locus BAB1_2029 in contig AM040264_GR.
KEGGbmf:BAB1_2029.
PATRIC17847149. VBIBruMel86222_2111.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0337.
HOGENOMHBG632303.
OMAMADEHEQ.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBMEL359391:BAB1_2029-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BRUA2
AccessionPrimary (citable) accession number: Q2YR43
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: February 7, 2006
Last modified: January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Brucella abortus strain 2308

Brucella abortus (strain 2308): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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